ID   HDEA_BRUSU              Reviewed;         114 AA.
AC   Q8FWV4; G0KC80;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Probable acid stress chaperone HdeA {ECO:0000255|HAMAP-Rule:MF_00946};
DE   Flags: Precursor;
GN   Name=hdeA {ECO:0000255|HAMAP-Rule:MF_00946};
GN   OrderedLocusNames=BRA0341, BS1330_II0338;
OS   Brucella suis biovar 1 (strain 1330).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=204722;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1330;
RX   PubMed=12271122; DOI=10.1073/pnas.192319099;
RA   Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F.,
RA   Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J.,
RA   Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R.,
RA   Nelson W.C., Ayodeji B., Kraul M., Shetty J., Malek J.A., Van Aken S.E.,
RA   Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L.,
RA   Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.;
RT   "The Brucella suis genome reveals fundamental similarities between animal
RT   and plant pathogens and symbionts.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1330;
RX   PubMed=22038969; DOI=10.1128/jb.06181-11;
RA   Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.;
RT   "Revised genome sequence of Brucella suis 1330.";
RL   J. Bacteriol. 193:6410-6410(2011).
CC   -!- FUNCTION: Required for optimal acid stress protection. Exhibits a
CC       chaperone-like activity only at low pH by suppressing non-specifically
CC       the aggregation of denaturated periplasmic proteins.
CC       {ECO:0000255|HAMAP-Rule:MF_00946}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_00946}.
CC   -!- SIMILARITY: Belongs to the HdeA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00946}.
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DR   EMBL; AE014292; AAN33539.1; -; Genomic_DNA.
DR   EMBL; CP002998; AEM19818.1; -; Genomic_DNA.
DR   RefSeq; WP_006191791.1; NZ_KN046805.1.
DR   AlphaFoldDB; Q8FWV4; -.
DR   SMR; Q8FWV4; -.
DR   EnsemblBacteria; AEM19818; AEM19818; BS1330_II0338.
DR   GeneID; 45053399; -.
DR   KEGG; bms:BRA0341; -.
DR   KEGG; bsi:BS1330_II0338; -.
DR   PATRIC; fig|204722.21.peg.161; -.
DR   HOGENOM; CLU_170142_0_0_5; -.
DR   OMA; ACTENKK; -.
DR   PhylomeDB; Q8FWV4; -.
DR   PRO; PR:Q8FWV4; -.
DR   Proteomes; UP000007104; Chromosome II.
DR   GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro.
DR   GO; GO:1990451; P:cellular stress response to acidic pH; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.890.10; -; 1.
DR   HAMAP; MF_00946; HdeA; 1.
DR   InterPro; IPR024972; HdeA.
DR   InterPro; IPR038303; HdeA/HdeB_sf.
DR   InterPro; IPR036831; HdeA_sf.
DR   InterPro; IPR010486; HNS-dep_expression_A/B.
DR   Pfam; PF06411; HdeA; 1.
DR   PIRSF; PIRSF009564; HNS-dep_expression_A; 1.
DR   SUPFAM; SSF47752; SSF47752; 1.
PE   3: Inferred from homology;
KW   Chaperone; Disulfide bond; Periplasm; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00946"
FT   CHAIN           27..114
FT                   /note="Probable acid stress chaperone HdeA"
FT                   /id="PRO_0000338637"
FT   DISULFID        46..94
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00946"
SQ   SEQUENCE   114 AA;  12362 MW;  EA4B34293EF0B73E CRC64;
     MIKALFNKNT ALAAVTILAL SGGAMAESAK THKTDMAKKK VSELTCEDFN GLEESFKPTV
     VGWVVGFNKK GKEEDAVIDV DGIETVTPAI IEACKQEPKA SFWKKAEAEL KKVF