ID   HDEB_SHIFL              Reviewed;         108 AA.
AC   P0AET4; P26605;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Acid stress chaperone HdeB {ECO:0000255|HAMAP-Rule:MF_00947};
DE   Flags: Precursor;
GN   Name=hdeB {ECO:0000255|HAMAP-Rule:MF_00947};
GN   OrderedLocusNames=SF3543, S4224;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Required for optimal acid stress protection, which is
CC       important for survival of enteric bacteria in the acidic environment of
CC       the host stomach. Exhibits a chaperone-like activity at acidic pH by
CC       preventing the aggregation of many different periplasmic proteins.
CC       {ECO:0000255|HAMAP-Rule:MF_00947}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_00947}.
CC   -!- SIMILARITY: Belongs to the HdeB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00947}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN44998.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAP19188.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE005674; AAN44998.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE014073; AAP19188.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_709291.1; NC_004337.2.
DR   RefSeq; WP_001298717.1; NZ_WPGW01000225.1.
DR   AlphaFoldDB; P0AET4; -.
DR   SMR; P0AET4; -.
DR   STRING; 198214.SF3543; -.
DR   PRIDE; P0AET4; -.
DR   EnsemblBacteria; AAN44998; AAN44998; SF3543.
DR   EnsemblBacteria; AAP19188; AAP19188; S4224.
DR   GeneID; 1026885; -.
DR   GeneID; 58463707; -.
DR   KEGG; sfl:SF3543; -.
DR   KEGG; sfx:S4224; -.
DR   PATRIC; fig|198214.7.peg.4173; -.
DR   HOGENOM; CLU_149189_1_0_6; -.
DR   OrthoDB; 1646886at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   GO; GO:1990451; P:cellular stress response to acidic pH; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.890.10; -; 1.
DR   HAMAP; MF_00947; HdeB; 1.
DR   InterPro; IPR038303; HdeA/HdeB_sf.
DR   InterPro; IPR028623; HdeB.
DR   InterPro; IPR010486; HNS-dep_expression_A/B.
DR   Pfam; PF06411; HdeA; 1.
PE   3: Inferred from homology;
KW   Acetylation; Chaperone; Periplasm; Reference proteome; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00947"
FT   CHAIN           30..108
FT                   /note="Acid stress chaperone HdeB"
FT                   /id="PRO_0000045103"
FT   MOD_RES         93
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   108 AA;  12043 MW;  4E80163ACFD1399F CRC64;
     MNISSLRKAF IFMGAVAALS LVNAQSALAA NESAKDMTCQ EFIDLNPKAM TPVAWWMLHE
     ETVYKGGDTV TLNETDLTQI PKVIEYCKKN PQKNLYTFKN QASNDLPN