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HDED_ECOLI
ID   HDED_ECOLI              Reviewed;         190 AA.
AC   P0AET5; P26603; P28326; Q2M7H3;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Protein HdeD;
GN   Name=hdeD; Synonyms=yhiA; OrderedLocusNames=b3511, JW3479;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12;
RX   PubMed=8244952; DOI=10.1128/jb.175.23.7747-7748.1993;
RA   Yoshida T., Ueguchi C., Mizuno T.;
RT   "Physical map location of a set of Escherichia coli genes (hde) whose
RT   expression is affected by the nucleoid protein H-NS.";
RL   J. Bacteriol. 175:7747-7748(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=8041620; DOI=10.1093/nar/22.13.2576;
RA   Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R.;
RT   "Analysis of the Escherichia coli genome. V. DNA sequence of the region
RT   from 76.0 to 81.5 minutes.";
RL   Nucleic Acids Res. 22:2576-2586(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-106.
RC   STRAIN=K12;
RX   PubMed=8455549; DOI=10.1007/bf00282791;
RA   Yoshida T., Ueguchi C., Yamada H., Mizuno T.;
RT   "Function of the Escherichia coli nucleoid protein, H-NS: molecular
RT   analysis of a subset of proteins whose expression is enhanced in a hns
RT   deletion mutant.";
RL   Mol. Gen. Genet. 237:113-122(1993).
RN   [6]
RP   TOPOLOGY [LARGE SCALE ANALYSIS].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=15919996; DOI=10.1126/science.1109730;
RA   Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT   "Global topology analysis of the Escherichia coli inner membrane
RT   proteome.";
RL   Science 308:1321-1323(2005).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA01882.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; D11389; BAA01985.1; -; Genomic_DNA.
DR   EMBL; U00039; AAB18487.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC76536.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE77783.1; -; Genomic_DNA.
DR   EMBL; D11109; BAA01882.1; ALT_INIT; Genomic_DNA.
DR   PIR; S47731; S47731.
DR   RefSeq; NP_417968.1; NC_000913.3.
DR   RefSeq; WP_000965672.1; NZ_STEB01000046.1.
DR   AlphaFoldDB; P0AET5; -.
DR   SMR; P0AET5; -.
DR   BioGRID; 4259561; 5.
DR   DIP; DIP-48170N; -.
DR   IntAct; P0AET5; 1.
DR   STRING; 511145.b3511; -.
DR   TCDB; 9.B.36.1.1; the acid resistance membrane protein (hded) family.
DR   jPOST; P0AET5; -.
DR   PaxDb; P0AET5; -.
DR   PRIDE; P0AET5; -.
DR   EnsemblBacteria; AAC76536; AAC76536; b3511.
DR   EnsemblBacteria; BAE77783; BAE77783; BAE77783.
DR   GeneID; 66672605; -.
DR   GeneID; 948024; -.
DR   KEGG; ecj:JW3479; -.
DR   KEGG; eco:b3511; -.
DR   PATRIC; fig|1411691.4.peg.3208; -.
DR   EchoBASE; EB1458; -.
DR   eggNOG; COG3247; Bacteria.
DR   HOGENOM; CLU_091585_6_0_6; -.
DR   InParanoid; P0AET5; -.
DR   OMA; VRGPQFG; -.
DR   PhylomeDB; P0AET5; -.
DR   BioCyc; EcoCyc:EG11495-MON; -.
DR   PRO; PR:P0AET5; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR   GO; GO:0009268; P:response to pH; IMP:EcoCyc.
DR   InterPro; IPR005325; DUF308_memb.
DR   Pfam; PF03729; DUF308; 2.
PE   1: Evidence at protein level;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..190
FT                   /note="Protein HdeD"
FT                   /id="PRO_0000083935"
FT   TOPO_DOM        1..25
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        45..47
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        48..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        71..76
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        100..103
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        127..138
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        162..164
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        188..190
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   190 AA;  20903 MW;  59FEAD58A13F7ECE CRC64;
     MLYIDKATIL KFDLEMLKKH RRAIQFIAVL LFIVGLLCIS FPFVSGDILS TVVGALLICS
     GIALIVGLFS NRSHNFWPVL SGFLVAVAYL LIGYFFIRAP ELGIFAIAAF IAGLFCVAGV
     IRLMSWYRQR SMKGSWLQLV IGVLDIVIAW IFLGATPMVS VTLVSTLVGI ELIFSAASLF
     SFASLFVKQQ
 
 
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