HDFR_ECO27
ID HDFR_ECO27 Reviewed; 279 AA.
AC B7UMM1;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 1.
DT 25-MAY-2022, entry version 72.
DE RecName: Full=HTH-type transcriptional regulator HdfR {ECO:0000255|HAMAP-Rule:MF_01233};
DE AltName: Full=H-NS-dependent flhDC regulator {ECO:0000255|HAMAP-Rule:MF_01233};
GN Name=hdfR {ECO:0000255|HAMAP-Rule:MF_01233}; OrderedLocusNames=E2348C_4066;
OS Escherichia coli O127:H6 (strain E2348/69 / EPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=574521;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E2348/69 / EPEC;
RX PubMed=18952797; DOI=10.1128/jb.01238-08;
RA Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T., Henderson I.R.,
RA Harris D., Asadulghani M., Kurokawa K., Dean P., Kenny B., Quail M.A.,
RA Thurston S., Dougan G., Hayashi T., Parkhill J., Frankel G.;
RT "Complete genome sequence and comparative genome analysis of
RT enteropathogenic Escherichia coli O127:H6 strain E2348/69.";
RL J. Bacteriol. 191:347-354(2009).
CC -!- FUNCTION: Negatively regulates the transcription of the flagellar
CC master operon flhDC by binding to the upstream region of the operon.
CC {ECO:0000255|HAMAP-Rule:MF_01233}.
CC -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC {ECO:0000305}.
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DR EMBL; FM180568; CAS11614.1; -; Genomic_DNA.
DR RefSeq; WP_000379245.1; NC_011601.1.
DR AlphaFoldDB; B7UMM1; -.
DR SMR; B7UMM1; -.
DR EnsemblBacteria; CAS11614; CAS11614; E2348C_4066.
DR GeneID; 58459581; -.
DR KEGG; ecg:E2348C_4066; -.
DR HOGENOM; CLU_039613_8_2_6; -.
DR OMA; ESLMNTW; -.
DR Proteomes; UP000008205; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.10; -; 1.
DR HAMAP; MF_01233; HTH_type_HdfR; 1.
DR InterPro; IPR005119; LysR_subst-bd.
DR InterPro; IPR020890; Tscrpt_reg_HTH_HdfR.
DR InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00126; HTH_1; 1.
DR Pfam; PF03466; LysR_substrate; 1.
DR PRINTS; PR00039; HTHLYSR.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50931; HTH_LYSR; 1.
PE 3: Inferred from homology;
KW DNA-binding; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..279
FT /note="HTH-type transcriptional regulator HdfR"
FT /id="PRO_1000164984"
FT DOMAIN 1..58
FT /note="HTH lysR-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01233"
FT DNA_BIND 18..37
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01233"
SQ SEQUENCE 279 AA; 31746 MW; 450FF5A542BDE903 CRC64;
MDTELLKTFL EVSRTRHFGR AAESLYLTQS AVSFRIRQLE NQLGVNLFTR HRNNIRLTAA
GEKLLPYAET LMSTWQAARK EVAHTSRHNE FSIGASASLW ECMLNQWLGR LYQNQDAHTG
LQFEARIAQR QSLVKQLHER QLDLLITTEA PKMDEFSSQL LGYFTLALYT SAPSKLKGDL
NYLRLEWGPD FQQHEAGLIG ADEVPILTTS SAELAQQQIA MLNGCTWLPV SWARKKGGLH
TVVDSTTLSR PLYAIWLQNS DKNALIRDLL KINVLDEVY