ID   HDFR_ECO7I              Reviewed;         279 AA.
AC   B7NU32;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=HTH-type transcriptional regulator HdfR {ECO:0000255|HAMAP-Rule:MF_01233};
DE   AltName: Full=H-NS-dependent flhDC regulator {ECO:0000255|HAMAP-Rule:MF_01233};
GN   Name=hdfR {ECO:0000255|HAMAP-Rule:MF_01233};
GN   OrderedLocusNames=ECIAI39_3021;
OS   Escherichia coli O7:K1 (strain IAI39 / ExPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=585057;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IAI39 / ExPEC;
RX   PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA   Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA   Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H.,
RA   Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E.,
RA   Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C.,
RA   Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S.,
RA   Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J.,
RA   Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT   "Organised genome dynamics in the Escherichia coli species results in
RT   highly diverse adaptive paths.";
RL   PLoS Genet. 5:E1000344-E1000344(2009).
CC   -!- FUNCTION: Negatively regulates the transcription of the flagellar
CC       master operon flhDC by binding to the upstream region of the operon.
CC       {ECO:0000255|HAMAP-Rule:MF_01233}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; CU928164; CAR19140.1; -; Genomic_DNA.
DR   RefSeq; WP_000379229.1; NC_011750.1.
DR   RefSeq; YP_002408951.1; NC_011750.1.
DR   AlphaFoldDB; B7NU32; -.
DR   SMR; B7NU32; -.
DR   STRING; 585057.ECIAI39_3021; -.
DR   EnsemblBacteria; CAR19140; CAR19140; ECIAI39_3021.
DR   KEGG; ect:ECIAI39_3021; -.
DR   PATRIC; fig|585057.6.peg.3133; -.
DR   HOGENOM; CLU_039613_8_2_6; -.
DR   OMA; ESLMNTW; -.
DR   Proteomes; UP000000749; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_01233; HTH_type_HdfR; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR020890; Tscrpt_reg_HTH_HdfR.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..279
FT                   /note="HTH-type transcriptional regulator HdfR"
FT                   /id="PRO_1000139664"
FT   DOMAIN          1..58
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01233"
FT   DNA_BIND        18..37
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01233"
SQ   SEQUENCE   279 AA;  31746 MW;  A09D66775F811352 CRC64;
     MDTELLKTFL EVSRTRHFGR AAESLYLTQS AVSFRIRQLE NQLGVNLFTR HRNNIRLTAA
     GEKLLPYAET LMSTWQAARK EVAHTSRHNE FSIGASASLW ECMLNQWLGR LYKNQDAHTG
     LQFEARIAQR QSLVKQLHER QLDLLITTEA PKMDEFSSQL LGYFTLALYT SAPSKLKGDL
     NYLRLEWGPD FQQHEAGLIG ADEVPILTTS SAELAQQQIA MLNGCTWLPV SWARKKGGLH
     TVVDSTTLSR PLYAIWLQNS DKNALIRDLL KINVLDEVY