HDFR_ESCF3
ID HDFR_ESCF3 Reviewed; 279 AA.
AC B7LUJ5;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=HTH-type transcriptional regulator HdfR {ECO:0000255|HAMAP-Rule:MF_01233};
DE AltName: Full=H-NS-dependent flhDC regulator {ECO:0000255|HAMAP-Rule:MF_01233};
GN Name=hdfR {ECO:0000255|HAMAP-Rule:MF_01233}; OrderedLocusNames=EFER_3738;
OS Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM
OS 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=585054;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35469 / DSM 13698 / BCRC 15582 / CCUG 18766 / IAM 14443 / JCM
RC 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73;
RX PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H.,
RA Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E.,
RA Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C.,
RA Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S.,
RA Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J.,
RA Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT "Organised genome dynamics in the Escherichia coli species results in
RT highly diverse adaptive paths.";
RL PLoS Genet. 5:E1000344-E1000344(2009).
CC -!- FUNCTION: Negatively regulates the transcription of the flagellar
CC master operon flhDC by binding to the upstream region of the operon.
CC {ECO:0000255|HAMAP-Rule:MF_01233}.
CC -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC {ECO:0000305}.
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DR EMBL; CU928158; CAQ91198.1; -; Genomic_DNA.
DR RefSeq; WP_000379255.1; NC_011740.1.
DR AlphaFoldDB; B7LUJ5; -.
DR SMR; B7LUJ5; -.
DR EnsemblBacteria; CAQ91198; CAQ91198; EFER_3738.
DR KEGG; efe:EFER_3738; -.
DR HOGENOM; CLU_039613_8_2_6; -.
DR OMA; ESLMNTW; -.
DR OrthoDB; 750230at2; -.
DR BioCyc; EFER585054:EFER_RS18725-MON; -.
DR Proteomes; UP000000745; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.10; -; 1.
DR HAMAP; MF_01233; HTH_type_HdfR; 1.
DR InterPro; IPR005119; LysR_subst-bd.
DR InterPro; IPR020890; Tscrpt_reg_HTH_HdfR.
DR InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00126; HTH_1; 1.
DR Pfam; PF03466; LysR_substrate; 1.
DR PRINTS; PR00039; HTHLYSR.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50931; HTH_LYSR; 1.
PE 3: Inferred from homology;
KW DNA-binding; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..279
FT /note="HTH-type transcriptional regulator HdfR"
FT /id="PRO_1000139670"
FT DOMAIN 1..58
FT /note="HTH lysR-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01233"
FT DNA_BIND 18..37
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01233"
SQ SEQUENCE 279 AA; 31829 MW; 517FC3B3346A2262 CRC64;
MDTELLKTFL EVSRTRHFGR AAESLYLTQS AVSFRIRQLE NQLGVNLFTR HRNNIRLTAA
GEKLLPYAET LMSTWQAARK EVAHTSRHNE FSIGASASLW ECMLNQWLGR LYQNQDTHTG
LQFEARIAQR QSLVKQLHER QLDLLITTEA PKMDEFSSQL LGYFTLALYT SAPSKLKGDL
NYLRLEWGPD FQQHEAGLIG TDEVPILTTS SAELAQQQIA MLNGCTWLPV SWARKKGGLH
TVVDSTTLSR PLYAIWLQNS DKHALIRDLL KINVLDEVY
