HDFR_SALDC
ID HDFR_SALDC Reviewed; 278 AA.
AC B5FN59;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 1.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=HTH-type transcriptional regulator HdfR {ECO:0000255|HAMAP-Rule:MF_01233};
DE AltName: Full=H-NS-dependent flhDC regulator {ECO:0000255|HAMAP-Rule:MF_01233};
GN Name=hdfR {ECO:0000255|HAMAP-Rule:MF_01233}; OrderedLocusNames=SeD_A4288;
OS Salmonella dublin (strain CT_02021853).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=439851;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT_02021853;
RX PubMed=21602358; DOI=10.1128/jb.00297-11;
RA Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G.,
RA Leclerc J.E., Ravel J., Cebula T.A.;
RT "Comparative genomics of 28 Salmonella enterica isolates: evidence for
RT CRISPR-mediated adaptive sublineage evolution.";
RL J. Bacteriol. 193:3556-3568(2011).
CC -!- FUNCTION: Negatively regulates the transcription of the flagellar
CC master operon flhDC by binding to the upstream region of the operon.
CC {ECO:0000255|HAMAP-Rule:MF_01233}.
CC -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP001144; ACH73640.1; -; Genomic_DNA.
DR AlphaFoldDB; B5FN59; -.
DR SMR; B5FN59; -.
DR KEGG; sed:SeD_A4288; -.
DR HOGENOM; CLU_039613_8_2_6; -.
DR OMA; ESLMNTW; -.
DR Proteomes; UP000008322; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.10; -; 1.
DR HAMAP; MF_01233; HTH_type_HdfR; 1.
DR InterPro; IPR005119; LysR_subst-bd.
DR InterPro; IPR020890; Tscrpt_reg_HTH_HdfR.
DR InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00126; HTH_1; 1.
DR Pfam; PF03466; LysR_substrate; 1.
DR PRINTS; PR00039; HTHLYSR.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50931; HTH_LYSR; 1.
PE 3: Inferred from homology;
KW DNA-binding; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..278
FT /note="HTH-type transcriptional regulator HdfR"
FT /id="PRO_1000139672"
FT DOMAIN 1..58
FT /note="HTH lysR-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01233"
FT DNA_BIND 18..37
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01233"
SQ SEQUENCE 278 AA; 31631 MW; 8ACFADFCE8BAED70 CRC64;
MDTELLKTFL EVSRTRHFGR AAEALYLTQS AVSFRIRQLE NQLGVNLFTR HRNNIRLTTA
GEKLLPYAET LMNTWQAARK EVAHTSRHNE FSIGASASLW ECMLNAWLGR LYQLQEPQSG
LQFEARIAQR QSLVKQLHER QLDLLITTEA PKMDEFSSQL LGHFTLALYC SSPARKKSEL
NYLRLEWGPD FQQHETGLIA ADKVPVLTTS SAELARQQLS ALNGCSWLPV NWANEKGGLH
TVADSATLSR PLYAIWLQNS DRYSLICDLL KTDVLDEQ