ID   HDFR_SALNS              Reviewed;         278 AA.
AC   B4SYF7;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=HTH-type transcriptional regulator HdfR {ECO:0000255|HAMAP-Rule:MF_01233};
DE   AltName: Full=H-NS-dependent flhDC regulator {ECO:0000255|HAMAP-Rule:MF_01233};
GN   Name=hdfR {ECO:0000255|HAMAP-Rule:MF_01233};
GN   OrderedLocusNames=SNSL254_A4180;
OS   Salmonella newport (strain SL254).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=423368;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SL254;
RX   PubMed=21602358; DOI=10.1128/jb.00297-11;
RA   Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G.,
RA   Leclerc J.E., Ravel J., Cebula T.A.;
RT   "Comparative genomics of 28 Salmonella enterica isolates: evidence for
RT   CRISPR-mediated adaptive sublineage evolution.";
RL   J. Bacteriol. 193:3556-3568(2011).
CC   -!- FUNCTION: Negatively regulates the transcription of the flagellar
CC       master operon flhDC by binding to the upstream region of the operon.
CC       {ECO:0000255|HAMAP-Rule:MF_01233}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; CP001113; ACF63495.1; -; Genomic_DNA.
DR   AlphaFoldDB; B4SYF7; -.
DR   SMR; B4SYF7; -.
DR   EnsemblBacteria; ACF63495; ACF63495; SNSL254_A4180.
DR   KEGG; see:SNSL254_A4180; -.
DR   HOGENOM; CLU_039613_8_2_6; -.
DR   OMA; ESLMNTW; -.
DR   Proteomes; UP000008824; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_01233; HTH_type_HdfR; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR020890; Tscrpt_reg_HTH_HdfR.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..278
FT                   /note="HTH-type transcriptional regulator HdfR"
FT                   /id="PRO_1000139674"
FT   DOMAIN          1..58
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01233"
FT   DNA_BIND        18..37
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01233"
SQ   SEQUENCE   278 AA;  31532 MW;  68DB3DF1530CE0CB CRC64;
     MDTELLKTFL EVSRTRHFGR AAEALYLTQS AVSFRIRQLE NQLGVNLFTR HRNNIRLTTA
     GEKLLPYAET LMNTWQAARK EVAHTSRHNE FSIGASASLW ECMLNAWLGR LYQLQEPQSG
     LQFEARIAQR QSLVKQLHER QLDLLITTEA PKMDEFSSQL LGHFTLALYC SSPARKKSEL
     NYLRLEWGPD FQQHETGLIA ADEVPVLTTS SAELARQQLS ALNGCSWLPV NWANEKGGLH
     TVADSATLSR PLYAIWLQNS DKYSLICDLL KTDVLDGQ