ID   HDFR_SALPC              Reviewed;         278 AA.
AC   C0Q2U0;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=HTH-type transcriptional regulator HdfR {ECO:0000255|HAMAP-Rule:MF_01233};
DE   AltName: Full=H-NS-dependent flhDC regulator {ECO:0000255|HAMAP-Rule:MF_01233};
GN   Name=hdfR {ECO:0000255|HAMAP-Rule:MF_01233}; OrderedLocusNames=SPC_4009;
OS   Salmonella paratyphi C (strain RKS4594).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=476213;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RKS4594;
RX   PubMed=19229335; DOI=10.1371/journal.pone.0004510;
RA   Liu W.-Q., Feng Y., Wang Y., Zou Q.-H., Chen F., Guo J.-T., Peng Y.-H.,
RA   Jin Y., Li Y.-G., Hu S.-N., Johnston R.N., Liu G.-R., Liu S.-L.;
RT   "Salmonella paratyphi C: genetic divergence from Salmonella choleraesuis
RT   and pathogenic convergence with Salmonella typhi.";
RL   PLoS ONE 4:E4510-E4510(2009).
CC   -!- FUNCTION: Negatively regulates the transcription of the flagellar
CC       master operon flhDC by binding to the upstream region of the operon.
CC       {ECO:0000255|HAMAP-Rule:MF_01233}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; CP000857; ACN48076.1; -; Genomic_DNA.
DR   AlphaFoldDB; C0Q2U0; -.
DR   SMR; C0Q2U0; -.
DR   EnsemblBacteria; ACN48076; ACN48076; SPC_4009.
DR   KEGG; sei:SPC_4009; -.
DR   HOGENOM; CLU_039613_8_2_6; -.
DR   OMA; ESLMNTW; -.
DR   Proteomes; UP000001599; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_01233; HTH_type_HdfR; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR020890; Tscrpt_reg_HTH_HdfR.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..278
FT                   /note="HTH-type transcriptional regulator HdfR"
FT                   /id="PRO_1000164987"
FT   DOMAIN          1..58
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01233"
FT   DNA_BIND        18..37
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01233"
SQ   SEQUENCE   278 AA;  31604 MW;  68D85DF1530CE0CB CRC64;
     MDTELLKTFL EVSRTRHFGR AAEALYLTQS AVSFRIRQLE NQLGVNLFTR HRNNIRLTTA
     GEKLLPYAET LMNTWQAARK EVAHTSRHNE FSIGASASLW ECMLNAWLGR LYQLQEPQSG
     LQFEARIAQR QSLVKQLHER QLDLLITTEA PKMDEFSSQL LGHFTLALYC SSPARKKSEL
     NYLRLEWGPD FQQHETGLIA ADEVPVLTTS SAELARQQLS ALNGCSWLPV NWANEKGGLH
     TVADSATLSR PLYAIWLQNS DKYSLICDLL KTDVLDEQ