HDFR_SALTY
ID HDFR_SALTY Reviewed; 278 AA.
AC P0A2Q0; Q8Z336; Q9L6T4;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=HTH-type transcriptional regulator HdfR {ECO:0000255|HAMAP-Rule:MF_01233};
DE AltName: Full=H-NS-dependent flhDC regulator {ECO:0000255|HAMAP-Rule:MF_01233};
GN Name=hdfR {ECO:0000255|HAMAP-Rule:MF_01233}; OrderedLocusNames=STM3897;
GN ORFNames=STMD1.99;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Negatively regulates the transcription of the flagellar
CC master operon flhDC by binding to the upstream region of the operon.
CC {ECO:0000255|HAMAP-Rule:MF_01233}.
CC -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF33488.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAL22747.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF233324; AAF33488.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE006468; AAL22747.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_462788.3; NC_003197.2.
DR AlphaFoldDB; P0A2Q0; -.
DR SMR; P0A2Q0; -.
DR STRING; 99287.STM3897; -.
DR PaxDb; P0A2Q0; -.
DR EnsemblBacteria; AAL22747; AAL22747; STM3897.
DR GeneID; 1255423; -.
DR KEGG; stm:STM3897; -.
DR PATRIC; fig|99287.12.peg.4119; -.
DR HOGENOM; CLU_039613_8_2_6; -.
DR OMA; ESLMNTW; -.
DR PhylomeDB; P0A2Q0; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR HAMAP; MF_01233; HTH_type_HdfR; 1.
DR InterPro; IPR005119; LysR_subst-bd.
DR InterPro; IPR020890; Tscrpt_reg_HTH_HdfR.
DR InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00126; HTH_1; 1.
DR Pfam; PF03466; LysR_substrate; 1.
DR PRINTS; PR00039; HTHLYSR.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50931; HTH_LYSR; 1.
PE 3: Inferred from homology;
KW DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..278
FT /note="HTH-type transcriptional regulator HdfR"
FT /id="PRO_0000105636"
FT DOMAIN 1..58
FT /note="HTH lysR-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01233"
FT DNA_BIND 18..37
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01233"
SQ SEQUENCE 278 AA; 31604 MW; 68D85DF1530CE0CB CRC64;
MDTELLKTFL EVSRTRHFGR AAEALYLTQS AVSFRIRQLE NQLGVNLFTR HRNNIRLTTA
GEKLLPYAET LMNTWQAARK EVAHTSRHNE FSIGASASLW ECMLNAWLGR LYQLQEPQSG
LQFEARIAQR QSLVKQLHER QLDLLITTEA PKMDEFSSQL LGHFTLALYC SSPARKKSEL
NYLRLEWGPD FQQHETGLIA ADEVPVLTTS SAELARQQLS ALNGCSWLPV NWANEKGGLH
TVADSATLSR PLYAIWLQNS DKYSLICDLL KTDVLDEQ
