ID   HDFR_SHIB3              Reviewed;         279 AA.
AC   B2TU26;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=HTH-type transcriptional regulator HdfR {ECO:0000255|HAMAP-Rule:MF_01233};
DE   AltName: Full=H-NS-dependent flhDC regulator {ECO:0000255|HAMAP-Rule:MF_01233};
GN   Name=hdfR {ECO:0000255|HAMAP-Rule:MF_01233};
GN   OrderedLocusNames=SbBS512_E4155;
OS   Shigella boydii serotype 18 (strain CDC 3083-94 / BS512).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=344609;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 3083-94 / BS512;
RA   Rasko D.A., Rosovitz M., Maurelli A.T., Myers G., Seshadri R., Cer R.,
RA   Jiang L., Ravel J., Sebastian Y.;
RT   "Complete sequence of Shigella boydii serotype 18 strain BS512.";
RL   Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negatively regulates the transcription of the flagellar
CC       master operon flhDC by binding to the upstream region of the operon.
CC       {ECO:0000255|HAMAP-Rule:MF_01233}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; CP001063; ACD08611.1; -; Genomic_DNA.
DR   RefSeq; WP_000379225.1; NC_010658.1.
DR   AlphaFoldDB; B2TU26; -.
DR   SMR; B2TU26; -.
DR   STRING; 344609.SbBS512_E4155; -.
DR   EnsemblBacteria; ACD08611; ACD08611; SbBS512_E4155.
DR   KEGG; sbc:SbBS512_E4155; -.
DR   HOGENOM; CLU_039613_8_2_6; -.
DR   OMA; ESLMNTW; -.
DR   Proteomes; UP000001030; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_01233; HTH_type_HdfR; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR020890; Tscrpt_reg_HTH_HdfR.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..279
FT                   /note="HTH-type transcriptional regulator HdfR"
FT                   /id="PRO_1000139677"
FT   DOMAIN          1..58
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01233"
FT   DNA_BIND        18..37
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01233"
SQ   SEQUENCE   279 AA;  31776 MW;  C49448618C5F54CD CRC64;
     MDTELLKTFL EVSRTRHFGR AAESLYLTQS AVSFRIRQLE NQLGVNLFTR HRNNIRLTAA
     GEKLLPYAEM LMSTWQAARK EVAHTSRHNE FSIGASASLW ECMLNQWLGR LYQNQDAHTG
     LQFEARIAQR QSLVKQLHER QLDLLITTEA PKMDEFSSQL LGYFTLALYT SAPSKLKGDL
     NYLRLEWGPD FQQHEAGLIG ADEVPILTTS SAELAQQQIA MLNGCTWLPV SWARKKGGLH
     TVVDSTTLSR PLYAIWLQNS DKNALIRDLL KINVLDEVY