ID   HDFR_SHISS              Reviewed;         279 AA.
AC   Q3YVK2;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=HTH-type transcriptional regulator HdfR {ECO:0000255|HAMAP-Rule:MF_01233};
DE   AltName: Full=H-NS-dependent flhDC regulator {ECO:0000255|HAMAP-Rule:MF_01233};
GN   Name=hdfR {ECO:0000255|HAMAP-Rule:MF_01233}; OrderedLocusNames=SSON_3932;
OS   Shigella sonnei (strain Ss046).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=300269;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ss046;
RX   PubMed=16275786; DOI=10.1093/nar/gki954;
RA   Yang F., Yang J., Zhang X., Chen L., Jiang Y., Yan Y., Tang X., Wang J.,
RA   Xiong Z., Dong J., Xue Y., Zhu Y., Xu X., Sun L., Chen S., Nie H., Peng J.,
RA   Xu J., Wang Y., Yuan Z., Wen Y., Yao Z., Shen Y., Qiang B., Hou Y., Yu J.,
RA   Jin Q.;
RT   "Genome dynamics and diversity of Shigella species, the etiologic agents of
RT   bacillary dysentery.";
RL   Nucleic Acids Res. 33:6445-6458(2005).
CC   -!- FUNCTION: Negatively regulates the transcription of the flagellar
CC       master operon flhDC by binding to the upstream region of the operon.
CC       {ECO:0000255|HAMAP-Rule:MF_01233}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; CP000038; AAZ90460.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q3YVK2; -.
DR   SMR; Q3YVK2; -.
DR   EnsemblBacteria; AAZ90460; AAZ90460; SSON_3932.
DR   KEGG; ssn:SSON_3932; -.
DR   HOGENOM; CLU_039613_8_2_6; -.
DR   OMA; ESLMNTW; -.
DR   Proteomes; UP000002529; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_01233; HTH_type_HdfR; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR020890; Tscrpt_reg_HTH_HdfR.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..279
FT                   /note="HTH-type transcriptional regulator HdfR"
FT                   /id="PRO_1000066900"
FT   DOMAIN          1..58
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01233"
FT   DNA_BIND        18..37
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01233"
SQ   SEQUENCE   279 AA;  31746 MW;  450FF5A542BDE903 CRC64;
     MDTELLKTFL EVSRTRHFGR AAESLYLTQS AVSFRIRQLE NQLGVNLFTR HRNNIRLTAA
     GEKLLPYAET LMSTWQAARK EVAHTSRHNE FSIGASASLW ECMLNQWLGR LYQNQDAHTG
     LQFEARIAQR QSLVKQLHER QLDLLITTEA PKMDEFSSQL LGYFTLALYT SAPSKLKGDL
     NYLRLEWGPD FQQHEAGLIG ADEVPILTTS SAELAQQQIA MLNGCTWLPV SWARKKGGLH
     TVVDSTTLSR PLYAIWLQNS DKNALIRDLL KINVLDEVY