ID   HDFR_YERPG              Reviewed;         293 AA.
AC   A9R8E7;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=HTH-type transcriptional regulator HdfR {ECO:0000255|HAMAP-Rule:MF_01233};
DE   AltName: Full=H-NS-dependent flhDC regulator {ECO:0000255|HAMAP-Rule:MF_01233};
GN   Name=hdfR {ECO:0000255|HAMAP-Rule:MF_01233};
GN   OrderedLocusNames=YpAngola_A0478;
OS   Yersinia pestis bv. Antiqua (strain Angola).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=349746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Angola;
RX   PubMed=20061468; DOI=10.1128/jb.01518-09;
RA   Eppinger M., Worsham P.L., Nikolich M.P., Riley D.R., Sebastian Y., Mou S.,
RA   Achtman M., Lindler L.E., Ravel J.;
RT   "Genome sequence of the deep-rooted Yersinia pestis strain Angola reveals
RT   new insights into the evolution and pangenome of the plague bacterium.";
RL   J. Bacteriol. 192:1685-1699(2010).
CC   -!- FUNCTION: Negatively regulates the transcription of the flagellar
CC       master operon flhDC by binding to the upstream region of the operon.
CC       {ECO:0000255|HAMAP-Rule:MF_01233}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; CP000901; ABX87320.1; -; Genomic_DNA.
DR   RefSeq; WP_002212020.1; NZ_CP009935.1.
DR   AlphaFoldDB; A9R8E7; -.
DR   SMR; A9R8E7; -.
DR   GeneID; 66843470; -.
DR   KEGG; ypg:YpAngola_A0478; -.
DR   PATRIC; fig|349746.12.peg.1428; -.
DR   OMA; ESLMNTW; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_01233; HTH_type_HdfR; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR020890; Tscrpt_reg_HTH_HdfR.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..293
FT                   /note="HTH-type transcriptional regulator HdfR"
FT                   /id="PRO_1000139679"
FT   DOMAIN          1..58
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01233"
FT   DNA_BIND        18..37
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01233"
SQ   SEQUENCE   293 AA;  33933 MW;  F5EC224D0D7E71EB CRC64;
     MDTELLKTFL EVSRTRHFGR AAESLYLTQS AVSFRIRQLE NQLGANLFTR HRNNIRLTPA
     GERLVPYAEM LLNTWRLAKK EVIHSLQHTE LSIGATASLW EAYLTPWLQQ LYEQQEELRL
     EARIALRNSL VKQLHERQLD LLITTEPPKM DELACLLLGH FSLRLYSSFS LDLPKEDDTP
     NEHKNASEVP YIKLEWGADF HQQENRLLDS EQAPILTTTS AHLTRQLLET TGGCAFLPEH
     WQKEYPQLVI HPDIPPIVRP LYAVWLQNSD QQALIRQLLK TPMNNATQSV TRE