HDFR_YERPS
ID HDFR_YERPS Reviewed; 293 AA.
AC Q66G51;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=HTH-type transcriptional regulator HdfR {ECO:0000255|HAMAP-Rule:MF_01233};
DE AltName: Full=H-NS-dependent flhDC regulator {ECO:0000255|HAMAP-Rule:MF_01233};
GN Name=hdfR {ECO:0000255|HAMAP-Rule:MF_01233}; OrderedLocusNames=YPTB0131;
OS Yersinia pseudotuberculosis serotype I (strain IP32953).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=273123;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IP32953;
RX PubMed=15358858; DOI=10.1073/pnas.0404012101;
RA Chain P.S.G., Carniel E., Larimer F.W., Lamerdin J., Stoutland P.O.,
RA Regala W.M., Georgescu A.M., Vergez L.M., Land M.L., Motin V.L.,
RA Brubaker R.R., Fowler J., Hinnebusch J., Marceau M., Medigue C.,
RA Simonet M., Chenal-Francisque V., Souza B., Dacheux D., Elliott J.M.,
RA Derbise A., Hauser L.J., Garcia E.;
RT "Insights into the evolution of Yersinia pestis through whole-genome
RT comparison with Yersinia pseudotuberculosis.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:13826-13831(2004).
CC -!- FUNCTION: Negatively regulates the transcription of the flagellar
CC master operon flhDC by binding to the upstream region of the operon.
CC {ECO:0000255|HAMAP-Rule:MF_01233}.
CC -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC {ECO:0000305}.
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DR EMBL; BX936398; CAH19371.1; -; Genomic_DNA.
DR RefSeq; WP_002212020.1; NZ_CP009712.1.
DR AlphaFoldDB; Q66G51; -.
DR SMR; Q66G51; -.
DR EnsemblBacteria; CAH19371; CAH19371; YPTB0131.
DR GeneID; 66843470; -.
DR KEGG; ypo:BZ17_2460; -.
DR KEGG; yps:YPTB0131; -.
DR PATRIC; fig|273123.14.peg.2584; -.
DR OMA; ESLMNTW; -.
DR Proteomes; UP000001011; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.10; -; 1.
DR HAMAP; MF_01233; HTH_type_HdfR; 1.
DR InterPro; IPR005119; LysR_subst-bd.
DR InterPro; IPR020890; Tscrpt_reg_HTH_HdfR.
DR InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00126; HTH_1; 1.
DR Pfam; PF03466; LysR_substrate; 1.
DR PRINTS; PR00039; HTHLYSR.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50931; HTH_LYSR; 1.
PE 3: Inferred from homology;
KW DNA-binding; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..293
FT /note="HTH-type transcriptional regulator HdfR"
FT /id="PRO_1000066906"
FT DOMAIN 1..58
FT /note="HTH lysR-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01233"
FT DNA_BIND 18..37
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01233"
SQ SEQUENCE 293 AA; 33933 MW; F5EC224D0D7E71EB CRC64;
MDTELLKTFL EVSRTRHFGR AAESLYLTQS AVSFRIRQLE NQLGANLFTR HRNNIRLTPA
GERLVPYAEM LLNTWRLAKK EVIHSLQHTE LSIGATASLW EAYLTPWLQQ LYEQQEELRL
EARIALRNSL VKQLHERQLD LLITTEPPKM DELACLLLGH FSLRLYSSFS LDLPKEDDTP
NEHKNASEVP YIKLEWGADF HQQENRLLDS EQAPILTTTS AHLTRQLLET TGGCAFLPEH
WQKEYPQLVI HPDIPPIVRP LYAVWLQNSD QQALIRQLLK TPMNNATQSV TRE