HDG12_ARATH
ID HDG12_ARATH Reviewed; 687 AA.
AC Q9LMT8; Q944S7;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Homeobox-leucine zipper protein HDG12 {ECO:0000303|PubMed:16778018};
DE AltName: Full=HD-ZIP protein HDG12 {ECO:0000303|PubMed:16778018};
DE AltName: Full=Homeodomain GLABRA 2-like protein 12 {ECO:0000303|PubMed:10809443};
DE AltName: Full=Homeodomain transcription factor HDG12 {ECO:0000303|PubMed:16778018};
DE AltName: Full=Protein HOMEODOMAIN GLABROUS 12 {ECO:0000303|PubMed:16778018};
GN Name=HDG12 {ECO:0000303|PubMed:16778018};
GN Synonyms=HDGL2-12 {ECO:0000303|PubMed:10809443};
GN OrderedLocusNames=At1g17920 {ECO:0000312|Araport:AT1G17920};
GN ORFNames=F2H15.14 {ECO:0000312|EMBL:AAF97271.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY.
RX PubMed=10809443; DOI=10.1023/a:1006368316413;
RA Tavares R., Aubourg S., Lecharny A., Kreis M.;
RT "Organization and structural evolution of four multigene families in
RT Arabidopsis thaliana: AtLCAD, AtLGT, AtMYST and AtHD-GL2.";
RL Plant Mol. Biol. 42:703-717(2000).
RN [5]
RP FUNCTION, TISSUE SPECIFICITY, GENE FAMILY, NOMENCLATURE, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=16778018; DOI=10.1104/pp.106.077388;
RA Nakamura M., Katsumata H., Abe M., Yabe N., Komeda Y., Yamamoto K.T.,
RA Takahashi T.;
RT "Characterization of the class IV homeodomain-leucine zipper gene family in
RT Arabidopsis.";
RL Plant Physiol. 141:1363-1375(2006).
RN [6]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. Columbia;
RX PubMed=23590515; DOI=10.1111/tpj.12211;
RA Kamata N., Okada H., Komeda Y., Takahashi T.;
RT "Mutations in epidermis-specific HD-ZIP IV genes affect floral organ
RT identity in Arabidopsis thaliana.";
RL Plant J. 75:430-440(2013).
RN [7]
RP FUNCTION.
RX PubMed=25358340; DOI=10.15252/msb.20145470;
RA Tian C., Zhang X., He J., Yu H., Wang Y., Shi B., Han Y., Wang G., Feng X.,
RA Zhang C., Wang J., Qi J., Yu R., Jiao Y.;
RT "An organ boundary-enriched gene regulatory network uncovers regulatory
RT hierarchies underlying axillary meristem initiation.";
RL Mol. Syst. Biol. 10:755-755(2014).
RN [8]
RP FUNCTION, DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE, AND INTERACTION WITH
RP BBM.
RC STRAIN=cv. Columbia;
RX PubMed=25564655; DOI=10.1242/dev.117168;
RA Horstman A., Fukuoka H., Muino J.M., Nitsch L., Guo C., Passarinho P.,
RA Sanchez-Perez G., Immink R., Angenent G., Boutilier K.;
RT "AIL and HDG proteins act antagonistically to control cell proliferation.";
RL Development 142:454-464(2015).
CC -!- FUNCTION: Probable transcription factor that acts as negative regulator
CC of trichome branching in association with HDG11 (PubMed:16778018).
CC Seems to promote cell differentiation (PubMed:25564655). May regulate
CC cell differentiation and proliferation during root and shoot meristem
CC development (PubMed:25564655). Acts as positive regulator of SCL18/LAS
CC expression (PubMed:25358340). Involved, together with PDF2, in the
CC regulation of flower organs development by promoting the expression of
CC APETALA 3 (AP3) in the epidermis and internal cell layers of developing
CC flowers (PubMed:23590515). {ECO:0000269|PubMed:16778018,
CC ECO:0000269|PubMed:23590515, ECO:0000269|PubMed:25358340,
CC ECO:0000269|PubMed:25564655}.
CC -!- SUBUNIT: Interacts with BBM. {ECO:0000269|PubMed:25564655}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- TISSUE SPECIFICITY: Expressed in apical meristems and young epidermal
CC tissue including trichomes and stipules. Expressed in lateral root
CC tips, the L1 layer of apical inflorescence meristems and early flower
CC primordia, carpel and stamen filament epidermis, stigma papillae, ovule
CC primordia, nucellus and embryo. {ECO:0000269|PubMed:16778018}.
CC -!- DEVELOPMENTAL STAGE: During embryo development, expressed in all cells
CC at the 4- and 16-cell embryo stages (PubMed:25564655). Expression is
CC restricted to the protoderm from the globular stage onward
CC (PubMed:25564655). In primary and lateral roots, observed in the
CC epidermis, the outer layer of columella cells and lateral root cap
CC (PubMed:25564655). {ECO:0000269|PubMed:25564655}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions, but the double mutants hdg11 and hdg12 exhibit excess
CC branching of trichomes (PubMed:16778018). The double mutant pdf2-1
CC hdg12-2 exhibits abnormal flowers with sepaloid petals and carpelloid
CC stamens in association with a reduced expression of APETALA 3 (AP3) in
CC the epidermis and internal cell layers of developing flowers
CC (PubMed:23590515). {ECO:0000269|PubMed:16778018,
CC ECO:0000269|PubMed:23590515}.
CC -!- SIMILARITY: Belongs to the HD-ZIP homeobox family. Class IV subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL11548.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
CC Sequence=AAN46804.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
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DR EMBL; AC034106; AAF97271.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE29652.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM61017.1; -; Genomic_DNA.
DR EMBL; AF424554; AAL11548.1; ALT_SEQ; mRNA.
DR EMBL; BT001050; AAN46804.1; ALT_SEQ; mRNA.
DR PIR; D86314; D86314.
DR RefSeq; NP_001323262.1; NM_001332324.1.
DR RefSeq; NP_564041.2; NM_101655.3.
DR AlphaFoldDB; Q9LMT8; -.
DR STRING; 3702.AT1G17920.1; -.
DR iPTMnet; Q9LMT8; -.
DR PaxDb; Q9LMT8; -.
DR PRIDE; Q9LMT8; -.
DR ProteomicsDB; 230312; -.
DR EnsemblPlants; AT1G17920.1; AT1G17920.1; AT1G17920.
DR EnsemblPlants; AT1G17920.2; AT1G17920.2; AT1G17920.
DR GeneID; 838371; -.
DR Gramene; AT1G17920.1; AT1G17920.1; AT1G17920.
DR Gramene; AT1G17920.2; AT1G17920.2; AT1G17920.
DR KEGG; ath:AT1G17920; -.
DR Araport; AT1G17920; -.
DR TAIR; locus:2030913; AT1G17920.
DR eggNOG; ENOG502QQXM; Eukaryota.
DR HOGENOM; CLU_015002_2_1_1; -.
DR InParanoid; Q9LMT8; -.
DR OMA; MGRPFSH; -.
DR OrthoDB; 250988at2759; -.
DR PhylomeDB; Q9LMT8; -.
DR PRO; PR:Q9LMT8; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9LMT8; baseline and differential.
DR Genevisible; Q9LMT8; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0048497; P:maintenance of floral organ identity; IGI:TAIR.
DR GO; GO:0010091; P:trichome branching; IGI:TAIR.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR InterPro; IPR042160; GLABRA2/ANL2/PDF2/ATML1-like.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR PANTHER; PTHR45654; PTHR45654; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF01852; START; 1.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00234; START; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50848; START; 1.
PE 1: Evidence at protein level;
KW Coiled coil; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..687
FT /note="Homeobox-leucine zipper protein HDG12"
FT /id="PRO_0000331673"
FT DOMAIN 206..440
FT /note="START"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00197"
FT DNA_BIND 21..80
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 87..150
FT /evidence="ECO:0000255"
SQ SEQUENCE 687 AA; 76527 MW; FDC27BC20BC45BFE CRC64;
MEFLGDSQNH DSSETEKKNK KKKRFHRHTP HQIQRLESTF NECQHPDEKQ RNQLSRELGL
APRQIKFWFQ NRRTQKKAQH ERADNCALKE ENDKIRCENI AIREAIKHAI CPSCGDSPVN
EDSYFDEQKL RIENAQLRDE LERVSSIAAK FLGRPISHLP PLLNPMHVSP LELFHTGPSL
DFDLLPGSCS SMSVPSLPSQ PNLVLSEMDK SLMTNIAVTA MEELLRLLQT NEPLWIKTDG
CRDVLNLENY ENMFTRSSTS GGKKNNLGME ASRSSGVVFT NAITLVDMLM NSVKLTELFP
SIVASSKTLA VISSGLRGNH GDALHLMIEE LQVLSPLVTT REFCVLRYCQ QIEHGTWAIV
NVSYEFPQFI SQSRSYRFPS GCLIQDMSNG YSKVTWVEHG EFEEQEPIHE MFKDIVHKGL
AFGAERWIAT LQRMCERFTN LLEPATSSLD LGGVIPSPEG KRSIMRLAHR MVSNFCLSVG
TSNNTRSTVV SGLDEFGIRV TSHKSRHEPN GMVLCAATSF WLPISPQNVF NFLKDERTRP
QWDVLSNGNS VQEVAHITNG SNPGNCISVL RGFNASSSQN NMLILQESCI DSSSAALVIY
TPVDLPALNI AMSGQDTSYI PILPSGFAIS PDGSSKGGGS LITVGFQIMV SGLQPAKLNM
ESMETVNNLI NTTVHQIKTT LNCPSTA
