HDG2_ARATH
ID HDG2_ARATH Reviewed; 721 AA.
AC Q94C37; O23045;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Homeobox-leucine zipper protein HDG2 {ECO:0000303|PubMed:16778018};
DE AltName: Full=HD-ZIP protein HDG2 {ECO:0000303|PubMed:16778018};
DE AltName: Full=Homeodomain GLABRA 2-like protein 2 {ECO:0000303|PubMed:10809443};
DE AltName: Full=Homeodomain transcription factor HDG2 {ECO:0000303|PubMed:16778018};
DE AltName: Full=Protein HOMEODOMAIN GLABROUS 2 {ECO:0000303|PubMed:16778018};
GN Name=HDG2 {ECO:0000303|PubMed:16778018};
GN Synonyms=HDGL2-2 {ECO:0000303|PubMed:10809443};
GN OrderedLocusNames=At1g05230 {ECO:0000312|Araport:AT1G05230};
GN ORFNames=YUP8H12.16 {ECO:0000312|EMBL:AAB71455.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY.
RX PubMed=10809443; DOI=10.1023/a:1006368316413;
RA Tavares R., Aubourg S., Lecharny A., Kreis M.;
RT "Organization and structural evolution of four multigene families in
RT Arabidopsis thaliana: AtLCAD, AtLGT, AtMYST and AtHD-GL2.";
RL Plant Mol. Biol. 42:703-717(2000).
RN [5]
RP TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16778018; DOI=10.1104/pp.106.077388;
RA Nakamura M., Katsumata H., Abe M., Yabe N., Komeda Y., Yamamoto K.T.,
RA Takahashi T.;
RT "Characterization of the class IV homeodomain-leucine zipper gene family in
RT Arabidopsis.";
RL Plant Physiol. 141:1363-1375(2006).
RN [6]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. Columbia;
RX PubMed=23590515; DOI=10.1111/tpj.12211;
RA Kamata N., Okada H., Komeda Y., Takahashi T.;
RT "Mutations in epidermis-specific HD-ZIP IV genes affect floral organ
RT identity in Arabidopsis thaliana.";
RL Plant J. 75:430-440(2013).
RN [7]
RP INTERACTION WITH AIL7/PLT7; ANT; BBM AND AIL1.
RC STRAIN=cv. Columbia;
RX PubMed=25564655; DOI=10.1242/dev.117168;
RA Horstman A., Fukuoka H., Muino J.M., Nitsch L., Guo C., Passarinho P.,
RA Sanchez-Perez G., Immink R., Angenent G., Boutilier K.;
RT "AIL and HDG proteins act antagonistically to control cell proliferation.";
RL Development 142:454-464(2015).
CC -!- FUNCTION: Probable transcription factor (By similarity). Involved,
CC together with PDF2, in the regulation of flower organs development by
CC promoting the expression of APETALA 3 (AP3) in the epidermis and
CC internal cell layers of developing flowers (PubMed:23590515).
CC {ECO:0000250|UniProtKB:Q0WV12, ECO:0000269|PubMed:23590515}.
CC -!- SUBUNIT: Interacts with AIL7/PLT7, ANT, BBM and AIL1.
CC {ECO:0000269|PubMed:25564655}.
CC -!- INTERACTION:
CC Q94C37; Q9LEZ9: TCP17; NbExp=3; IntAct=EBI-15196469, EBI-15192327;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q94C37-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Expressed in hairless cell files of the hypocotyl
CC epidermis. Expressed in shoot apical meristem (SAM) with higher levels
CC in L1 cells and the epidermal layer of young leaves (PubMed:16778018).
CC Expressed in primary root tips, in the L1 of apical inflorescence
CC meristems, early flower primordia, carpel epidermis, ovule primordia,
CC nucellus, chalaze and seed coat (PubMed:16778018).
CC {ECO:0000269|PubMed:16778018}.
CC -!- DISRUPTION PHENOTYPE: The double mutant pdf2-1 hdg2-3 exhibits abnormal
CC flowers with sepaloid petals and carpelloid stamens in association with
CC a reduced expression of APETALA 3 (AP3) in the epidermis and internal
CC cell layers of developing flowers. {ECO:0000269|PubMed:23590515}.
CC -!- SIMILARITY: Belongs to the HD-ZIP homeobox family. Class IV subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB71455.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC000098; AAB71455.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE27809.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE27810.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE27812.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60381.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60382.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60383.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60384.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60385.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60386.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60388.1; -; Genomic_DNA.
DR EMBL; AY037177; AAK59762.1; -; mRNA.
DR EMBL; AY091690; AAM10289.1; -; mRNA.
DR PIR; G86186; G86186.
DR RefSeq; NP_001184911.1; NM_001197982.1. [Q94C37-1]
DR RefSeq; NP_001322673.1; NM_001331531.1. [Q94C37-1]
DR RefSeq; NP_001322674.1; NM_001331532.1. [Q94C37-1]
DR RefSeq; NP_001322675.1; NM_001331533.1. [Q94C37-1]
DR RefSeq; NP_001322676.1; NM_001331534.1. [Q94C37-1]
DR RefSeq; NP_001322677.1; NM_001331535.1. [Q94C37-1]
DR RefSeq; NP_001322678.1; NM_001331529.1. [Q94C37-1]
DR RefSeq; NP_001322680.1; NM_001331528.1. [Q94C37-1]
DR RefSeq; NP_172015.1; NM_100402.3. [Q94C37-1]
DR RefSeq; NP_849596.1; NM_179265.2. [Q94C37-1]
DR AlphaFoldDB; Q94C37; -.
DR BioGRID; 24491; 18.
DR IntAct; Q94C37; 18.
DR STRING; 3702.AT1G05230.4; -.
DR PaxDb; Q94C37; -.
DR ProteomicsDB; 230375; -. [Q94C37-1]
DR EnsemblPlants; AT1G05230.1; AT1G05230.1; AT1G05230. [Q94C37-1]
DR EnsemblPlants; AT1G05230.10; AT1G05230.10; AT1G05230. [Q94C37-1]
DR EnsemblPlants; AT1G05230.11; AT1G05230.11; AT1G05230. [Q94C37-1]
DR EnsemblPlants; AT1G05230.2; AT1G05230.2; AT1G05230. [Q94C37-1]
DR EnsemblPlants; AT1G05230.4; AT1G05230.4; AT1G05230. [Q94C37-1]
DR EnsemblPlants; AT1G05230.5; AT1G05230.5; AT1G05230. [Q94C37-1]
DR EnsemblPlants; AT1G05230.6; AT1G05230.6; AT1G05230. [Q94C37-1]
DR EnsemblPlants; AT1G05230.7; AT1G05230.7; AT1G05230. [Q94C37-1]
DR EnsemblPlants; AT1G05230.8; AT1G05230.8; AT1G05230. [Q94C37-1]
DR EnsemblPlants; AT1G05230.9; AT1G05230.9; AT1G05230. [Q94C37-1]
DR GeneID; 839256; -.
DR Gramene; AT1G05230.1; AT1G05230.1; AT1G05230. [Q94C37-1]
DR Gramene; AT1G05230.10; AT1G05230.10; AT1G05230. [Q94C37-1]
DR Gramene; AT1G05230.11; AT1G05230.11; AT1G05230. [Q94C37-1]
DR Gramene; AT1G05230.2; AT1G05230.2; AT1G05230. [Q94C37-1]
DR Gramene; AT1G05230.4; AT1G05230.4; AT1G05230. [Q94C37-1]
DR Gramene; AT1G05230.5; AT1G05230.5; AT1G05230. [Q94C37-1]
DR Gramene; AT1G05230.6; AT1G05230.6; AT1G05230. [Q94C37-1]
DR Gramene; AT1G05230.7; AT1G05230.7; AT1G05230. [Q94C37-1]
DR Gramene; AT1G05230.8; AT1G05230.8; AT1G05230. [Q94C37-1]
DR Gramene; AT1G05230.9; AT1G05230.9; AT1G05230. [Q94C37-1]
DR KEGG; ath:AT1G05230; -.
DR Araport; AT1G05230; -.
DR TAIR; locus:2207235; AT1G05230.
DR eggNOG; ENOG502QU3P; Eukaryota.
DR InParanoid; Q94C37; -.
DR OMA; QWSMVFA; -.
DR PhylomeDB; Q94C37; -.
DR PRO; PR:Q94C37; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q94C37; baseline and differential.
DR Genevisible; Q94C37; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0048497; P:maintenance of floral organ identity; IGI:TAIR.
DR GO; GO:0010090; P:trichome morphogenesis; IMP:TAIR.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR InterPro; IPR042160; GLABRA2/ANL2/PDF2/ATML1-like.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR PANTHER; PTHR45654; PTHR45654; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF01852; START; 1.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00234; START; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50848; START; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; DNA-binding; Homeobox; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..721
FT /note="Homeobox-leucine zipper protein HDG2"
FT /id="PRO_0000331664"
FT DOMAIN 242..468
FT /note="START"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00197"
FT DNA_BIND 64..123
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 17..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 120..194
FT /evidence="ECO:0000255"
FT COMPBIAS 26..41
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 721 AA; 79424 MW; 652287B59AF9CCB9 CRC64;
MFEPNMLLAA MNNADSNNHN YNHEDNNNEG FLRDDEFDSP NTKSGSENQE GGSGNDQDPL
HPNKKKRYHR HTQLQIQEME AFFKECPHPD DKQRKQLSRE LNLEPLQVKF WFQNKRTQMK
NHHERHENSH LRAENEKLRN DNLRYREALA NASCPNCGGP TAIGEMSFDE HQLRLENARL
REEIDRISAI AAKYVGKPVS NYPLMSPPPL PPRPLELAMG NIGGEAYGNN PNDLLKSITA
PTESDKPVII DLSVAAMEEL MRMVQVDEPL WKSLVLDEEE YARTFPRGIG PRPAGYRSEA
SRESAVVIMN HVNIVEILMD VNQWSTIFAG MVSRAMTLAV LSTGVAGNYN GALQVMSAEF
QVPSPLVPTR ETYFARYCKQ QGDGSWAVVD ISLDSLQPNP PARCRRRASG CLIQELPNGY
SKVTWVEHVE VDDRGVHNLY KHMVSTGHAF GAKRWVAILD RQCERLASVM ATNISSGEVG
VITNQEGRRS MLKLAERMVI SFCAGVSAST AHTWTTLSGT GAEDVRVMTR KSVDDPGRPP
GIVLSAATSF WIPVPPKRVF DFLRDENSRN EWDILSNGGV VQEMAHIANG RDTGNCVSLL
RVNSANSSQS NMLILQESCT DPTASFVIYA PVDIVAMNIV LNGGDPDYVA LLPSGFAILP
DGNANSGAPG GDGGSLLTVA FQILVDSVPT AKLSLGSVAT VNNLIACTVE RIKASMSCET
A
