HDG3_ARATH
ID HDG3_ARATH Reviewed; 725 AA.
AC Q9ZV65; A7LBA8;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 2.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Homeobox-leucine zipper protein HDG3 {ECO:0000303|PubMed:16778018};
DE AltName: Full=HD-ZIP protein HDG3 {ECO:0000303|PubMed:16778018};
DE AltName: Full=Homeodomain GLABRA 2-like protein 3 {ECO:0000303|PubMed:10809443};
DE AltName: Full=Homeodomain transcription factor HDG3 {ECO:0000303|PubMed:16778018};
DE AltName: Full=Protein HOMEODOMAIN GLABROUS 3 {ECO:0000303|PubMed:16778018};
DE AltName: Full=Protein UPCURVED LEAF 1 {ECO:0000303|Ref.1};
GN Name=HDG3 {ECO:0000303|PubMed:16778018};
GN Synonyms=HDGL2-3 {ECO:0000303|PubMed:10809443}, UCL1 {ECO:0000303|Ref.1};
GN OrderedLocusNames=At2g32370 {ECO:0000312|Araport:AT2G32370};
GN ORFNames=T32F6.11 {ECO:0000312|EMBL:AAC69941.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC STRAIN=cv. Columbia;
RX AGRICOLA=IND43961341; DOI=10.1016/j.plantsci.2007.08.011;
RA Li Q.-J., Xu B., Chen X.-Y., Wang L.-J.;
RT "The effects of increased expression of an Arabidopsis HD-ZIP gene on leaf
RT morphogenesis and anther dehiscence.";
RL Plant Sci. 173:567-576(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP GENE FAMILY.
RX PubMed=10809443; DOI=10.1023/a:1006368316413;
RA Tavares R., Aubourg S., Lecharny A., Kreis M.;
RT "Organization and structural evolution of four multigene families in
RT Arabidopsis thaliana: AtLCAD, AtLGT, AtMYST and AtHD-GL2.";
RL Plant Mol. Biol. 42:703-717(2000).
RN [5]
RP TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16778018; DOI=10.1104/pp.106.077388;
RA Nakamura M., Katsumata H., Abe M., Yabe N., Komeda Y., Yamamoto K.T.,
RA Takahashi T.;
RT "Characterization of the class IV homeodomain-leucine zipper gene family in
RT Arabidopsis.";
RL Plant Physiol. 141:1363-1375(2006).
RN [6]
RP FUNCTION, DISRUPTION PHENOTYPE, AND INTERACTION WITH AIL7/PLT7; ANT; BBM
RP AND AIL1.
RC STRAIN=cv. Columbia;
RX PubMed=25564655; DOI=10.1242/dev.117168;
RA Horstman A., Fukuoka H., Muino J.M., Nitsch L., Guo C., Passarinho P.,
RA Sanchez-Perez G., Immink R., Angenent G., Boutilier K.;
RT "AIL and HDG proteins act antagonistically to control cell proliferation.";
RL Development 142:454-464(2015).
CC -!- FUNCTION: Probable transcription factor (By similarity). Seems to
CC promote cell differentiation (PubMed:25564655).
CC {ECO:0000250|UniProtKB:Q9LTK3, ECO:0000269|PubMed:25564655}.
CC -!- SUBUNIT: Interacts with AIL7/PLT7, ANT, BBM and AIL1.
CC {ECO:0000269|PubMed:25564655}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC ECO:0000269|Ref.1}.
CC -!- TISSUE SPECIFICITY: Expressed in siliques.
CC {ECO:0000269|PubMed:16778018, ECO:0000269|Ref.1}.
CC -!- DISRUPTION PHENOTYPE: In plants missing HDG3, HDG7, HDG11, PDF2 and
CC ATML1, increased cell division leading to cell overproliferation.
CC {ECO:0000269|PubMed:25564655}.
CC -!- SIMILARITY: Belongs to the HD-ZIP homeobox family. Class IV subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC69941.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; EF988635; ABS18315.1; -; mRNA.
DR EMBL; AC005700; AAC69941.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC08674.1; -; Genomic_DNA.
DR PIR; C84732; C84732.
DR RefSeq; NP_180796.2; NM_128796.3.
DR AlphaFoldDB; Q9ZV65; -.
DR STRING; 3702.AT2G32370.1; -.
DR PaxDb; Q9ZV65; -.
DR PRIDE; Q9ZV65; -.
DR ProteomicsDB; 247171; -.
DR EnsemblPlants; AT2G32370.1; AT2G32370.1; AT2G32370.
DR GeneID; 817798; -.
DR Gramene; AT2G32370.1; AT2G32370.1; AT2G32370.
DR KEGG; ath:AT2G32370; -.
DR Araport; AT2G32370; -.
DR TAIR; locus:2062540; AT2G32370.
DR eggNOG; ENOG502QU3P; Eukaryota.
DR HOGENOM; CLU_015002_2_1_1; -.
DR InParanoid; Q9ZV65; -.
DR OMA; ANNRTNW; -.
DR OrthoDB; 279393at2759; -.
DR PhylomeDB; Q9ZV65; -.
DR PRO; PR:Q9ZV65; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9ZV65; baseline and differential.
DR Genevisible; Q9ZV65; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0048825; P:cotyledon development; IGI:TAIR.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR InterPro; IPR042160; GLABRA2/ANL2/PDF2/ATML1-like.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR PANTHER; PTHR45654; PTHR45654; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF01852; START; 1.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00234; START; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50848; START; 1.
PE 1: Evidence at protein level;
KW Coiled coil; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..725
FT /note="Homeobox-leucine zipper protein HDG3"
FT /id="PRO_0000331665"
FT DOMAIN 243..475
FT /note="START"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00197"
FT DNA_BIND 68..127
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 117..201
FT /evidence="ECO:0000255"
FT COMPBIAS 1..59
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 725 AA; 80070 MW; F3F524152017C2F7 CRC64;
MSQSNMVPVA NNGDNNNDNE NNNNNNNNGG TDNTNAGNDS GDQDFDSGNT SSGNHGEGLG
NNQAPRHKKK KYNRHTQLQI SEMEAFFREC PHPDDKQRYD LSAQLGLDPV QIKFWFQNKR
TQNKNQQERF ENSELRNLNN HLRSENQRLR EAIHQALCPK CGGQTAIGEM TFEEHHLRIL
NARLTEEIKQ LSVTAEKISR LTGIPVRSHP RVSPPNPPPN FEFGMGSKGN VGNHSRETTG
PADANTKPII MELAFGAMEE LLVMAQVAEP LWMGGFNGTS LALNLDEYEK TFRTGLGPRL
GGFRTEASRE TALVAMCPTG IVEMLMQENL WSTMFAGIVG RARTHEQIMA DAAGNFNGNL
QIMSAEYQVL SPLVTTRESY FVRYCKQQGE GLWAVVDISI DHLLPNINLK CRRRPSGCLI
QEMHSGYSKV TWVEHVEVDD AGSYSIFEKL ICTGQAFAAN RWVGTLVRQC ERISSILSTD
FQSVDSGDHI TLTNHGKMSM LKIAERIART FFAGMTNATG STIFSGVEGE DIRVMTMKSV
NDPGKPPGVI ICAATSFWLP APPNTVFDFL REATHRHNWD VLCNGEMMHK IAEITNGIDK
RNCASLLRHG HTSKSKMMIV QETSTDPTAS FVLYAPVDMT SMDITLHGGG DPDFVVILPS
GFAIFPDGTG KPGGKEGGSL LTISFQMLVE SGPEARLSVS SVATTENLIR TTVRRIKDLF
PCQTA
