HDG7_ARATH
ID HDG7_ARATH Reviewed; 682 AA.
AC Q9LTK3;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Homeobox-leucine zipper protein HDG7 {ECO:0000303|PubMed:16778018};
DE AltName: Full=HD-ZIP protein HDG7 {ECO:0000303|PubMed:16778018};
DE AltName: Full=Homeodomain GLABRA 2-like protein 7 {ECO:0000303|PubMed:10809443};
DE AltName: Full=Homeodomain transcription factor HDG7 {ECO:0000303|PubMed:16778018};
DE AltName: Full=Protein HOMEODOMAIN GLABROUS 7 {ECO:0000303|PubMed:16778018};
GN Name=HDG7 {ECO:0000303|PubMed:16778018};
GN Synonyms=HDGL2-7 {ECO:0000303|PubMed:10809443};
GN OrderedLocusNames=At5g52170 {ECO:0000312|Araport:AT5G52170};
GN ORFNames=F17P19.7 {ECO:0000312|EMBL:BAA97460.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RA Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY.
RX PubMed=10809443; DOI=10.1023/a:1006368316413;
RA Tavares R., Aubourg S., Lecharny A., Kreis M.;
RT "Organization and structural evolution of four multigene families in
RT Arabidopsis thaliana: AtLCAD, AtLGT, AtMYST and AtHD-GL2.";
RL Plant Mol. Biol. 42:703-717(2000).
RN [4]
RP FUNCTION, TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16778018; DOI=10.1104/pp.106.077388;
RA Nakamura M., Katsumata H., Abe M., Yabe N., Komeda Y., Yamamoto K.T.,
RA Takahashi T.;
RT "Characterization of the class IV homeodomain-leucine zipper gene family in
RT Arabidopsis.";
RL Plant Physiol. 141:1363-1375(2006).
RN [5]
RP FUNCTION, DISRUPTION PHENOTYPE, AND INTERACTION WITH AIL7/PLT7.
RC STRAIN=cv. Columbia;
RX PubMed=25564655; DOI=10.1242/dev.117168;
RA Horstman A., Fukuoka H., Muino J.M., Nitsch L., Guo C., Passarinho P.,
RA Sanchez-Perez G., Immink R., Angenent G., Boutilier K.;
RT "AIL and HDG proteins act antagonistically to control cell proliferation.";
RL Development 142:454-464(2015).
CC -!- FUNCTION: Probable transcription factor that binds to the DNA sequence
CC 5'-GCATTAAATGC-3' (PubMed:16778018). Seems to promote cell
CC differentiation (PubMed:25564655). {ECO:0000269|PubMed:16778018,
CC ECO:0000269|PubMed:25564655}.
CC -!- SUBUNIT: Interacts with AIL7/PLT7. {ECO:0000269|PubMed:25564655}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in cells around the base of leaf
CC primordia, in the outermost 2 to 3 cell layers along the boundary
CC between two leaf primordia. Expressed in lateral root primordia and
CC tips, and in the epidermal boundaries of two cotyledons at heart-stage
CC embryo. {ECO:0000269|PubMed:16778018}.
CC -!- DISRUPTION PHENOTYPE: In plants missing HDG3, HDG7, HDG11, PDF2 and
CC ATML1, increased cell division leading to cell overproliferation.
CC {ECO:0000269|PubMed:25564655}.
CC -!- SIMILARITY: Belongs to the HD-ZIP homeobox family. Class IV subfamily.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB025603; BAA97460.1; -; Genomic_DNA.
DR EMBL; CP002688; AED96179.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM70486.1; -; Genomic_DNA.
DR RefSeq; NP_001318786.1; NM_001344986.1.
DR RefSeq; NP_200030.1; NM_124596.2.
DR AlphaFoldDB; Q9LTK3; -.
DR SMR; Q9LTK3; -.
DR STRING; 3702.AT5G52170.1; -.
DR PaxDb; Q9LTK3; -.
DR PRIDE; Q9LTK3; -.
DR ProteomicsDB; 230292; -.
DR EnsemblPlants; AT5G52170.1; AT5G52170.1; AT5G52170.
DR EnsemblPlants; AT5G52170.3; AT5G52170.3; AT5G52170.
DR GeneID; 835293; -.
DR Gramene; AT5G52170.1; AT5G52170.1; AT5G52170.
DR Gramene; AT5G52170.3; AT5G52170.3; AT5G52170.
DR KEGG; ath:AT5G52170; -.
DR Araport; AT5G52170; -.
DR TAIR; locus:2145116; AT5G52170.
DR eggNOG; ENOG502QWUC; Eukaryota.
DR HOGENOM; CLU_015002_2_1_1; -.
DR InParanoid; Q9LTK3; -.
DR OMA; ITASPIH; -.
DR PhylomeDB; Q9LTK3; -.
DR PRO; PR:Q9LTK3; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9LTK3; baseline and differential.
DR Genevisible; Q9LTK3; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:TAIR.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR InterPro; IPR042160; GLABRA2/ANL2/PDF2/ATML1-like.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR PANTHER; PTHR45654; PTHR45654; 2.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF01852; START; 1.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00234; START; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50848; START; 1.
PE 1: Evidence at protein level;
KW Coiled coil; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..682
FT /note="Homeobox-leucine zipper protein HDG7"
FT /id="PRO_0000331668"
FT DOMAIN 214..429
FT /note="START"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00197"
FT DNA_BIND 57..116
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 33..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 105..186
FT /evidence="ECO:0000255"
FT COMPBIAS 33..52
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 682 AA; 75638 MW; 7A941DD7ADCC84C1 CRC64;
MNGDLEVDMS RGDFNPSFFL GKLKDDEFES RSLSDDSFDA MSGDEDKQEQ RPKKKKRKTK
YHRHTSYQIQ ELESFFKECP HPNEKQRLEL GKKLTLESKQ IKFWFQNRRT QMKTQLERHE
NVILKQENEK LRLENSFLKE SMRGSLCIDC GGAVIPGEVS FEQHQLRIEN AKLKEELDRI
CALANRFIGG SISLEQPSNG GIGSQHLPIG HCVSGGTSLM FMDLAMEAMD ELLKLAELET
SLWSSKSEKG SMNHFPGSRE TGLVLINSLA LVETLMDTNK WAEMFECIVA VASTLEVISN
GSDGSRNGSI LLMQAEFQVM SPLVPIKQKK FLRYCKQHGD GLWAVVDVSY DINRGNENLK
SYGGSKMFPS GCIIQDIGNG CSKVTWIEHS EYEESHTHSL YQPLLSSSVG LGATKWLATL
QRQCESFTML LSSEDHTGLS HAGTKSILKL AQRMKLNFYS GITASCIHKW EKLLAENVGQ
DTRILTRKSL EPSGIVLSAA TSLWLPVTQQ RLFEFLCDGK CRNQWDILSN GASMENTLLV
PKGQQEGSCV SLLRAAGNDQ NESSMLILQE TWNDVSGALV VYAPVDIPSM NTVMSGGDSA
YVALLPSGFS ILPDGSSSSS DQFDTDGGLV NQESKGCLLT VGFQILVNSL PTAKLNVESV
ETVNNLIACT IHKIRAALRI PA
