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HDG8_ARATH
ID   HDG8_ARATH              Reviewed;         699 AA.
AC   Q9M9P4; Q8GY47;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 2.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=Homeobox-leucine zipper protein HDG8 {ECO:0000303|PubMed:16778018};
DE   AltName: Full=HD-ZIP protein HDG8 {ECO:0000303|PubMed:16778018};
DE   AltName: Full=Homeodomain GLABRA 2-like protein 8 {ECO:0000303|PubMed:10809443};
DE   AltName: Full=Homeodomain transcription factor HDG8 {ECO:0000303|PubMed:16778018};
DE   AltName: Full=Protein HOMEODOMAIN GLABROUS 8 {ECO:0000303|PubMed:16778018};
GN   Name=HDG8 {ECO:0000303|PubMed:16778018};
GN   Synonyms=HDGL2-8 {ECO:0000303|PubMed:10809443};
GN   OrderedLocusNames=At3g03260 {ECO:0000312|Araport:AT3G03260};
GN   ORFNames=T17B22.5 {ECO:0000312|EMBL:AAF26121.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11910074; DOI=10.1126/science.1071006;
RA   Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA   Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA   Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA   Shinagawa A., Shinozaki K.;
RT   "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL   Science 296:141-145(2002).
RN   [4]
RP   GENE FAMILY.
RX   PubMed=10809443; DOI=10.1023/a:1006368316413;
RA   Tavares R., Aubourg S., Lecharny A., Kreis M.;
RT   "Organization and structural evolution of four multigene families in
RT   Arabidopsis thaliana: AtLCAD, AtLGT, AtMYST and AtHD-GL2.";
RL   Plant Mol. Biol. 42:703-717(2000).
RN   [5]
RP   TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=16778018; DOI=10.1104/pp.106.077388;
RA   Nakamura M., Katsumata H., Abe M., Yabe N., Komeda Y., Yamamoto K.T.,
RA   Takahashi T.;
RT   "Characterization of the class IV homeodomain-leucine zipper gene family in
RT   Arabidopsis.";
RL   Plant Physiol. 141:1363-1375(2006).
RN   [6]
RP   INTERACTION WITH ANT.
RC   STRAIN=cv. Columbia;
RX   PubMed=25564655; DOI=10.1242/dev.117168;
RA   Horstman A., Fukuoka H., Muino J.M., Nitsch L., Guo C., Passarinho P.,
RA   Sanchez-Perez G., Immink R., Angenent G., Boutilier K.;
RT   "AIL and HDG proteins act antagonistically to control cell proliferation.";
RL   Development 142:454-464(2015).
CC   -!- FUNCTION: Probable transcription factor. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with ANT. {ECO:0000269|PubMed:25564655}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in the embryo at early stage and in the
CC       endosperm. {ECO:0000269|PubMed:16778018}.
CC   -!- SIMILARITY: Belongs to the HD-ZIP homeobox family. Class IV subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF26121.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=BAC42508.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AC012328; AAF26121.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002686; AEE73918.1; -; Genomic_DNA.
DR   EMBL; AK117867; BAC42508.1; ALT_FRAME; mRNA.
DR   RefSeq; NP_186976.2; NM_111196.2.
DR   AlphaFoldDB; Q9M9P4; -.
DR   SMR; Q9M9P4; -.
DR   STRING; 3702.AT3G03260.1; -.
DR   PaxDb; Q9M9P4; -.
DR   PRIDE; Q9M9P4; -.
DR   ProteomicsDB; 230314; -.
DR   EnsemblPlants; AT3G03260.1; AT3G03260.1; AT3G03260.
DR   GeneID; 821305; -.
DR   Gramene; AT3G03260.1; AT3G03260.1; AT3G03260.
DR   KEGG; ath:AT3G03260; -.
DR   Araport; AT3G03260; -.
DR   TAIR; locus:2097770; AT3G03260.
DR   eggNOG; ENOG502QTNV; Eukaryota.
DR   HOGENOM; CLU_015002_2_1_1; -.
DR   InParanoid; Q9M9P4; -.
DR   OMA; QDCYMDA; -.
DR   OrthoDB; 244362at2759; -.
DR   PhylomeDB; Q9M9P4; -.
DR   PRO; PR:Q9M9P4; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9M9P4; baseline and differential.
DR   Genevisible; Q9M9P4; AT.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR   GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 3.30.530.20; -; 1.
DR   InterPro; IPR042160; GLABRA2/ANL2/PDF2/ATML1-like.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR023393; START-like_dom_sf.
DR   InterPro; IPR002913; START_lipid-bd_dom.
DR   PANTHER; PTHR45654; PTHR45654; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF01852; START; 1.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00234; START; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS50848; START; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..699
FT                   /note="Homeobox-leucine zipper protein HDG8"
FT                   /id="PRO_0000331669"
FT   DOMAIN          204..438
FT                   /note="START"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00197"
FT   DNA_BIND        23..82
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          89..149
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..21
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   699 AA;  78426 MW;  3EB8723000AA005E CRC64;
     MDNNGGGSSG NEQYTSGDAK QNGKRTCHRH TPQQIQRLEA YFKECPHPDE RQRNQLCREL
     KLEPDQIKFW FQNKRTQSKT QEDRSTNVLL RGENETLQSD NEAMLDALKS VLCPACGGPP
     FGREERGHNL QKLRFENARL KDHRDRISNF VDQHKPNEPT VEDSLAYVPS LDRISYGING
     GNMYEPSSSY GPPNFQIIQP RPLAETDMSL LSEIAASAVE ELKRLFLAEE QFWVKSCIDE
     TYVIDTESYE RFSHAVKHFS STTAHVESSK AVTVVHVEAI NLIQMFLDPE KWKELFPTIV
     NKANTIHVLG SGLPIRGNCN VLQVMWEQLH ILSPLVPARE FMVVRCCQEI EKGIWIIADV
     SHRANFDFGN AACYKRPSGC LIQALPDAHS KVMWIEHVEV DHKLDTHKIY RDLLSGGSGY
     GAKRWIVTLE RMCERMALSS IQTLPPSDRS EVITTGEARR SVMKLGERMV KNFNEMLTMS
     GKIDFPQQSK NGVRVSIRMN IEAGQPPGIV VSASSSLAIP LTPLQVFAFL QNLDTRQQWD
     ILSYGTVVNE IARIVTGSSE TNCVTILRVH PTHEENNDKM VVQDSCKDDM LMLQDCYMDA
     LGGMIVYAPM DMATMHFAVS GEVDPSHIPI LPSGFVISSD GRRSTVEDGG TLLTVAFQIL
     VSGKANRSRE VNEKSVDTVS ALISSTIQRI KGLLNCPEC
 
 
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