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HDGL1_HUMAN
ID   HDGL1_HUMAN             Reviewed;         251 AA.
AC   Q5TGJ6; Q96MJ6;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Hepatoma-derived growth factor-like protein 1;
DE   AltName: Full=PWWP domain-containing protein 1;
GN   Name=HDGFL1; Synonyms=PWWP1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the HDGF family. {ECO:0000305}.
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DR   EMBL; AK056824; BAB71292.1; -; mRNA.
DR   EMBL; AL033539; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471087; EAW55436.1; -; Genomic_DNA.
DR   CCDS; CCDS34347.1; -.
DR   RefSeq; NP_612641.2; NM_138574.3.
DR   AlphaFoldDB; Q5TGJ6; -.
DR   SMR; Q5TGJ6; -.
DR   BioGRID; 127538; 9.
DR   STRING; 9606.ENSP00000442129; -.
DR   PhosphoSitePlus; Q5TGJ6; -.
DR   BioMuta; HDGFL1; -.
DR   DMDM; 74746497; -.
DR   MassIVE; Q5TGJ6; -.
DR   PaxDb; Q5TGJ6; -.
DR   PeptideAtlas; Q5TGJ6; -.
DR   PRIDE; Q5TGJ6; -.
DR   ProteomicsDB; 65121; -.
DR   Antibodypedia; 64027; 96 antibodies from 15 providers.
DR   DNASU; 154150; -.
DR   Ensembl; ENST00000510882.4; ENSP00000442129.1; ENSG00000112273.7.
DR   GeneID; 154150; -.
DR   KEGG; hsa:154150; -.
DR   MANE-Select; ENST00000510882.4; ENSP00000442129.1; NM_138574.4; NP_612641.2.
DR   UCSC; uc003nds.4; human.
DR   CTD; 154150; -.
DR   GeneCards; HDGFL1; -.
DR   HGNC; HGNC:21095; HDGFL1.
DR   HPA; ENSG00000112273; Tissue enriched (testis).
DR   neXtProt; NX_Q5TGJ6; -.
DR   OpenTargets; ENSG00000112273; -.
DR   PharmGKB; PA134981303; -.
DR   VEuPathDB; HostDB:ENSG00000112273; -.
DR   eggNOG; KOG1904; Eukaryota.
DR   GeneTree; ENSGT00940000163720; -.
DR   HOGENOM; CLU_090867_0_0_1; -.
DR   InParanoid; Q5TGJ6; -.
DR   OMA; AYGMPMY; -.
DR   OrthoDB; 530959at2759; -.
DR   PhylomeDB; Q5TGJ6; -.
DR   TreeFam; TF105385; -.
DR   PathwayCommons; Q5TGJ6; -.
DR   BioGRID-ORCS; 154150; 6 hits in 1064 CRISPR screens.
DR   GenomeRNAi; 154150; -.
DR   Pharos; Q5TGJ6; Tdark.
DR   PRO; PR:Q5TGJ6; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; Q5TGJ6; protein.
DR   Bgee; ENSG00000112273; Expressed in sperm and 41 other tissues.
DR   ExpressionAtlas; Q5TGJ6; baseline and differential.
DR   Genevisible; Q5TGJ6; HS.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd05834; HDGF_related; 1.
DR   InterPro; IPR035496; HDGF-rel_PWWP.
DR   InterPro; IPR000313; PWWP_dom.
DR   Pfam; PF00855; PWWP; 1.
DR   SMART; SM00293; PWWP; 1.
DR   PROSITE; PS50812; PWWP; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..251
FT                   /note="Hepatoma-derived growth factor-like protein 1"
FT                   /id="PRO_0000334652"
FT   DOMAIN          11..62
FT                   /note="PWWP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00162"
FT   REGION          89..251
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        111..179
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        220..234
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        235..251
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         87
FT                   /note="T -> M (in dbSNP:rs2076506)"
FT                   /id="VAR_043447"
FT   CONFLICT        28
FT                   /note="R -> G (in Ref. 1; BAB71292)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        31
FT                   /note="H -> R (in Ref. 1; BAB71292)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        92
FT                   /note="D -> Y (in Ref. 1; BAB71292)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        198
FT                   /note="L -> P (in Ref. 1; BAB71292)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   251 AA;  27234 MW;  B97777F3DAD16A77 CRC64;
     MSAYGMPMYK SGDLVFAKLK GYAHWPARIE HMTQPNRYQV FFFGTHETAF LSPKRLFPYK
     ECKEKFGKPN KRRGFSAGLW EIENNPTVQA SDCPLASEKG SGDGPWPEPE AAEGDEDKPT
     HAGGGGDELG KPDDDKPTEE EKGPLKRSAG DPPEDAPKRP KEAAPDQEEE AEAERAAEAE
     RAAAAAAATA VDEESPFLVA VENGSAPSEP GLVCEPPQPE EEELREEEVA DEEASQEWHA
     EAPGGGDRDS L
 
 
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