HDGR2_DANRE
ID HDGR2_DANRE Reviewed; 662 AA.
AC Q5XXA7; B8A4B6; Q1LYH9; Q803X2;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-SEP-2009, sequence version 2.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Hepatoma-derived growth factor-related protein 2;
DE Short=HRP-2;
GN Name=hdgfl2; Synonyms=hdgfrp2; ORFNames=si:ch211-232a14.3, zgc:66215;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Kidney;
RX PubMed=15371438; DOI=10.1074/jbc.m406307200;
RA Cherepanov P., Devroe E., Silver P.A., Engelman A.;
RT "Identification of an evolutionarily conserved domain in human lens
RT epithelium-derived growth factor/transcriptional co-activator p75
RT (LEDGF/p75) that binds HIV-1 integrase.";
RL J. Biol. Chem. 279:48883-48892(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-417.
RC STRAIN=AB;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May act as a regulator of myogenesis (By similarity).
CC Promotes the repair of DNA double-strand breaks (DSBs) through the
CC homologous recombination pathway by facilitating the recruitment of the
CC DNA endonuclease RBBP8 to the DSBs (By similarity).
CC {ECO:0000250|UniProtKB:Q7Z4V5}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q3UMU9}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q925G1}.
CC -!- SIMILARITY: Belongs to the HDGF family. {ECO:0000305}.
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DR EMBL; AY728142; AAU44351.1; -; mRNA.
DR EMBL; BX005201; CAX13226.1; -; Genomic_DNA.
DR EMBL; CU207239; CAX13226.1; JOINED; Genomic_DNA.
DR EMBL; BC044157; AAH44157.1; -; mRNA.
DR RefSeq; NP_001002037.2; NM_001002037.2.
DR AlphaFoldDB; Q5XXA7; -.
DR SMR; Q5XXA7; -.
DR STRING; 7955.ENSDARP00000103259; -.
DR PaxDb; Q5XXA7; -.
DR PRIDE; Q5XXA7; -.
DR GeneID; 80965; -.
DR KEGG; dre:80965; -.
DR CTD; 84717; -.
DR ZFIN; ZDB-GENE-040426-2104; hdgfl2.
DR eggNOG; KOG1904; Eukaryota.
DR InParanoid; Q5XXA7; -.
DR OrthoDB; 530959at2759; -.
DR PhylomeDB; Q5XXA7; -.
DR PRO; PR:Q5XXA7; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR GO; GO:1905168; P:positive regulation of double-strand break repair via homologous recombination; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd05834; HDGF_related; 1.
DR Gene3D; 1.20.930.10; -; 1.
DR InterPro; IPR035496; HDGF-rel_PWWP.
DR InterPro; IPR036218; HIVI-bd_sf.
DR InterPro; IPR021567; LEDGF_IBD.
DR InterPro; IPR000313; PWWP_dom.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR Pfam; PF11467; LEDGF; 1.
DR Pfam; PF00855; PWWP; 1.
DR SMART; SM00293; PWWP; 1.
DR SUPFAM; SSF140576; SSF140576; 1.
DR PROSITE; PS50812; PWWP; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; DNA damage; DNA recombination; DNA repair;
KW Myogenesis; Nucleus; Reference proteome.
FT CHAIN 1..662
FT /note="Hepatoma-derived growth factor-related protein 2"
FT /id="PRO_0000317646"
FT DOMAIN 7..64
FT /note="PWWP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00162"
FT REGION 84..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 561..662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 320..370
FT /evidence="ECO:0000255"
FT COMPBIAS 84..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..146
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..174
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..298
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 310..368
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..406
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..453
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..484
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 564..630
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 641..662
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 152
FT /note="L -> P (in Ref. 1; AAU44351 and 3; AAH44157)"
FT /evidence="ECO:0000305"
FT CONFLICT 398
FT /note="I -> T (in Ref. 3; AAH44157)"
FT /evidence="ECO:0000305"
FT CONFLICT 402
FT /note="S -> F (in Ref. 3; AAH44157)"
FT /evidence="ECO:0000305"
FT CONFLICT 417
FT /note="E -> K (in Ref. 3; AAH44157)"
FT /evidence="ECO:0000305"
FT CONFLICT 437
FT /note="V -> I (in Ref. 1; AAU44351)"
FT /evidence="ECO:0000305"
FT CONFLICT 455
FT /note="A -> P (in Ref. 1; AAU44351)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 662 AA; 73488 MW; 477FAC9DBD4FC290 CRC64;
MPHNFRPGDL VFAKMKGYPH WPARIEDVAD GAVKPPPNKI PIFFFGTHET AFLAPKDLFA
YEKNQERFGK PNKRKGFNEG LWEIQNNPHA SYNTPAAASS SDSEDNQPAA ASDAEEEEEA
VVPRKAETGS DDSDSGSEDQ KKPAVKRKAP ALKRPPVKKA RASSSDRDGE ESGSPSEPEP
SPSSDSDSGK NSDQDFTPQK ESGGRGGKKP AGRGRRKKAS SGSDSDSGSQ SDQKAARSDS
EDEKPRPAAS GSESQSGSKS DSDSEPPPPP PPTRKAPQGR KKAEKPPPKP RARKPKPAPE
RAPSSSSDSD SDSDTDRVSE WKKRDEERRK ELEERRKREE AEELRRLRER EKEEEEKRKK
DKETKVRRGS SSSGSSSSDD EVDDHPLKKS KKPPPPPIPA PSDSDSPPPS ELKKKKESQK
GRQKKEKEVK EKKERPVKEK KPQRSEEKHK AKPKAEKPKR KPVRPPEKKV EKKKEPSPEE
KLQKLHTDIK FALKVDNPDI EKCLQALDEL SSVQVTTHIL QKNADVIATL KKIRRYKASN
AVMEKATAVY NKLKLQFIGK IETGKPKPNE KNQEEQDAQN TDDSKPVNGE SEGERKDVSE
SESNSKPTDQ DNPDENKSPN GIRPDPDEPA DQLNDSTEAD PTADADVKED SREQDEQMSS
ES
