HDGR2_XENTR
ID HDGR2_XENTR Reviewed; 643 AA.
AC Q6P4K1;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Hepatoma-derived growth factor-related protein 2;
DE Short=HRP-2;
GN Name=hdgfl2; Synonyms=hdgfrp2;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May act as a regulator of myogenesis (By similarity).
CC Promotes the repair of DNA double-strand breaks (DSBs) through the
CC homologous recombination pathway by facilitating the recruitment of the
CC DNA endonuclease RBBP8 to the DSBs (By similarity).
CC {ECO:0000250|UniProtKB:Q7Z4V5}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q3UMU9}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q925G1}.
CC -!- SIMILARITY: Belongs to the HDGF family. {ECO:0000305}.
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DR EMBL; BC063366; AAH63366.1; -; mRNA.
DR RefSeq; NP_989176.1; NM_203845.1.
DR AlphaFoldDB; Q6P4K1; -.
DR SMR; Q6P4K1; -.
DR STRING; 8364.ENSXETP00000052142; -.
DR PaxDb; Q6P4K1; -.
DR DNASU; 394783; -.
DR GeneID; 394783; -.
DR KEGG; xtr:394783; -.
DR CTD; 84717; -.
DR Xenbase; XB-GENE-6456056; hdgfl2.
DR eggNOG; KOG1904; Eukaryota.
DR InParanoid; Q6P4K1; -.
DR OMA; AVHRKTY; -.
DR OrthoDB; 530959at2759; -.
DR TreeFam; TF105385; -.
DR Proteomes; UP000008143; Chromosome 1.
DR Proteomes; UP000790000; Unplaced.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR GO; GO:1905168; P:positive regulation of double-strand break repair via homologous recombination; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd05834; HDGF_related; 1.
DR Gene3D; 1.20.930.10; -; 1.
DR InterPro; IPR035496; HDGF-rel_PWWP.
DR InterPro; IPR036218; HIVI-bd_sf.
DR InterPro; IPR021567; LEDGF_IBD.
DR InterPro; IPR000313; PWWP_dom.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR Pfam; PF11467; LEDGF; 1.
DR Pfam; PF00855; PWWP; 1.
DR SMART; SM00293; PWWP; 1.
DR SUPFAM; SSF140576; SSF140576; 1.
DR PROSITE; PS50812; PWWP; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; DNA damage; DNA recombination; DNA repair;
KW Myogenesis; Nucleus; Reference proteome.
FT CHAIN 1..643
FT /note="Hepatoma-derived growth factor-related protein 2"
FT /id="PRO_0000317648"
FT DOMAIN 7..64
FT /note="PWWP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00162"
FT REGION 88..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 548..643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 295..345
FT /evidence="ECO:0000255"
FT COMPBIAS 88..106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..121
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..232
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..281
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..351
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..450
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..580
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..618
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 619..643
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 643 AA; 72266 MW; 2FB2D91D1490A868 CRC64;
MPLNFKPGDL VFAKMKGYPH WPARIDDVKD GAVKPPPNKY PIFFYGTHET AFLAPKDLFP
YEKCKDKYGK PNKRKGFNEG LWEIQNNPQA SYSLPPASVS SSDSDVPEEK STARSDGEEE
QETGQAILPT AGVSSSDEEG SDKGGVKRKG RTTTPPSAKR TKHSSSEQEP DSASSSEEEN
SDSDQDFTPE KSTPRIQRRT TNLGKKNKIF AESDSKSDES EDEKKEEEQK KSPSSSSASS
PSLSSSDSEA PVKKTPRGRR PAEKPAPKPR GRGRKAEPIP SSDSSDSDSS VDRISEWKKR
DEERRRELEE RRKKEQEEQL RRLREEEREE EERKKREKAE KGDKSDSDSD SSKSEVIAPP
KPKKSSSSSD SEEDKKPVKE VKPVASEIKK GKKEKVRAIS DDSDSDKKVK KTIKKTRPSE
SARKTNQKEK RGERPRGRPS KVEKEKKKPE VITARKVVKK EPTVEEKLQK LHSEIKFALK
VDNPDIQKCL DALEELGGLQ VTSQILQKNT DVVATLKKIR RYKANQSVMD KAAEVYSRIK
ARILGPKLES QQKTVQKVNT AEKDPEEEKQ TGKVEEDMDA SVNGDFLSQR IETAGDKEQD
GEGQNLDNKT EMETKQNNHA EHNSNPTEET IECRLISSEN QTS
