HDGR3_HUMAN
ID HDGR3_HUMAN Reviewed; 203 AA.
AC Q9Y3E1;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Hepatoma-derived growth factor-related protein 3;
DE Short=HRP-3;
DE AltName: Full=Hepatoma-derived growth factor 2;
DE Short=HDGF-2;
GN Name=HDGFL3 {ECO:0000312|HGNC:HGNC:24937}; Synonyms=HDGF2, HDGFRP3;
GN ORFNames=CGI-142;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RC TISSUE=Lymphocyte;
RX PubMed=10581169; DOI=10.1006/bbrc.1999.1733;
RA Ikegame K., Yamamoto M., Kishima Y., Enomoto H., Yoshida K., Suemura M.,
RA Kishimoto T., Nakamura H.;
RT "A new member of a hepatoma-derived growth factor gene family can
RT translocate to the nucleus.";
RL Biochem. Biophys. Res. Commun. 266:81-87(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Yu L., Fu Q., Tu Q.;
RT "Cloning of a novel human cDNA which is a homolog to mouse hepatoma-derived
RT growth factor (mHDGF) and termed hHDGF2.";
RL Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=10810093; DOI=10.1101/gr.10.5.703;
RA Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.;
RT "Identification of novel human genes evolutionarily conserved in
RT Caenorhabditis elegans by comparative proteomics.";
RL Genome Res. 10:703-713(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-162, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
CC -!- FUNCTION: Enhances DNA synthesis and may play a role in cell
CC proliferation. {ECO:0000269|PubMed:10581169}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10581169}.
CC -!- TISSUE SPECIFICITY: Detected in testis, heart, spinal cord and brain.
CC {ECO:0000269|PubMed:10581169}.
CC -!- SIMILARITY: Belongs to the HDGF family. {ECO:0000305}.
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DR EMBL; AB029156; BAA90477.1; -; mRNA.
DR EMBL; AF110642; AAM27001.1; -; mRNA.
DR EMBL; AF151900; AAD34137.1; -; mRNA.
DR EMBL; AK001280; BAA91597.1; -; mRNA.
DR EMBL; BC015483; AAH15483.1; -; mRNA.
DR CCDS; CCDS32314.1; -.
DR PIR; JC7163; JC7163.
DR RefSeq; NP_057157.1; NM_016073.3.
DR PDB; 6IIP; X-ray; 0.95 A; A/B=8-94.
DR PDB; 6IIQ; X-ray; 1.85 A; A/B/C=1-99.
DR PDB; 6IIR; X-ray; 2.20 A; A/B=1-99.
DR PDB; 6IIS; X-ray; 2.36 A; A/B=1-99.
DR PDB; 6IIT; X-ray; 2.10 A; A/B=1-99.
DR PDBsum; 6IIP; -.
DR PDBsum; 6IIQ; -.
DR PDBsum; 6IIR; -.
DR PDBsum; 6IIS; -.
DR PDBsum; 6IIT; -.
DR AlphaFoldDB; Q9Y3E1; -.
DR BMRB; Q9Y3E1; -.
DR SMR; Q9Y3E1; -.
DR BioGRID; 119129; 29.
DR IntAct; Q9Y3E1; 17.
DR STRING; 9606.ENSP00000299633; -.
DR GlyGen; Q9Y3E1; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9Y3E1; -.
DR PhosphoSitePlus; Q9Y3E1; -.
DR SwissPalm; Q9Y3E1; -.
DR BioMuta; HDGFL3; -.
DR DMDM; 68052386; -.
DR EPD; Q9Y3E1; -.
DR jPOST; Q9Y3E1; -.
DR MassIVE; Q9Y3E1; -.
DR MaxQB; Q9Y3E1; -.
DR PaxDb; Q9Y3E1; -.
DR PeptideAtlas; Q9Y3E1; -.
DR PRIDE; Q9Y3E1; -.
DR ProteomicsDB; 86028; -.
DR TopDownProteomics; Q9Y3E1; -.
DR Antibodypedia; 28189; 194 antibodies from 29 providers.
DR DNASU; 50810; -.
DR Ensembl; ENST00000299633.7; ENSP00000299633.4; ENSG00000166503.9.
DR GeneID; 50810; -.
DR KEGG; hsa:50810; -.
DR MANE-Select; ENST00000299633.7; ENSP00000299633.4; NM_016073.4; NP_057157.1.
DR UCSC; uc002bjs.3; human.
DR CTD; 50810; -.
DR DisGeNET; 50810; -.
DR GeneCards; HDGFL3; -.
DR HGNC; HGNC:24937; HDGFL3.
DR HPA; ENSG00000166503; Low tissue specificity.
DR neXtProt; NX_Q9Y3E1; -.
DR OpenTargets; ENSG00000166503; -.
DR VEuPathDB; HostDB:ENSG00000166503; -.
DR eggNOG; KOG1904; Eukaryota.
DR GeneTree; ENSGT00940000153942; -.
DR HOGENOM; CLU_090867_1_0_1; -.
DR InParanoid; Q9Y3E1; -.
DR OMA; CIRNPFA; -.
DR OrthoDB; 784438at2759; -.
DR PhylomeDB; Q9Y3E1; -.
DR PathwayCommons; Q9Y3E1; -.
DR SignaLink; Q9Y3E1; -.
DR BioGRID-ORCS; 50810; 11 hits in 1035 CRISPR screens.
DR ChiTaRS; HDGFL3; human.
DR GeneWiki; HDGFRP3; -.
DR GenomeRNAi; 50810; -.
DR Pharos; Q9Y3E1; Tbio.
DR PRO; PR:Q9Y3E1; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q9Y3E1; protein.
DR Bgee; ENSG00000166503; Expressed in cortical plate and 209 other tissues.
DR ExpressionAtlas; Q9Y3E1; baseline and differential.
DR Genevisible; Q9Y3E1; HS.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0005576; C:extracellular region; HDA:BHF-UCL.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0015631; F:tubulin binding; ISS:UniProtKB.
DR GO; GO:0046785; P:microtubule polymerization; ISS:UniProtKB.
DR GO; GO:0007026; P:negative regulation of microtubule depolymerization; ISS:UniProtKB.
DR GO; GO:0031175; P:neuron projection development; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd05834; HDGF_related; 1.
DR InterPro; IPR035496; HDGF-rel_PWWP.
DR InterPro; IPR000313; PWWP_dom.
DR Pfam; PF00855; PWWP; 1.
DR SMART; SM00293; PWWP; 1.
DR PROSITE; PS50812; PWWP; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Growth factor; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..203
FT /note="Hepatoma-derived growth factor-related protein 3"
FT /id="PRO_0000191703"
FT DOMAIN 11..68
FT /note="PWWP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00162"
FT REGION 97..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 136..148
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 97..117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..139
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..155
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..181
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 110
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9JMG7"
FT MOD_RES 121
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9JMG7"
FT MOD_RES 122
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9JMG7"
FT MOD_RES 162
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21406692"
FT STRAND 14..17
FT /evidence="ECO:0007829|PDB:6IIP"
FT STRAND 25..29
FT /evidence="ECO:0007829|PDB:6IIP"
FT STRAND 34..36
FT /evidence="ECO:0007829|PDB:6IIT"
FT STRAND 44..48
FT /evidence="ECO:0007829|PDB:6IIP"
FT TURN 49..51
FT /evidence="ECO:0007829|PDB:6IIP"
FT STRAND 54..57
FT /evidence="ECO:0007829|PDB:6IIP"
FT HELIX 59..61
FT /evidence="ECO:0007829|PDB:6IIP"
FT STRAND 62..64
FT /evidence="ECO:0007829|PDB:6IIP"
FT HELIX 65..72
FT /evidence="ECO:0007829|PDB:6IIP"
FT HELIX 79..90
FT /evidence="ECO:0007829|PDB:6IIP"
FT TURN 92..95
FT /evidence="ECO:0007829|PDB:6IIQ"
SQ SEQUENCE 203 AA; 22620 MW; 0B660D665F01659C CRC64;
MARPRPREYK AGDLVFAKMK GYPHWPARID ELPEGAVKPP ANKYPIFFFG THETAFLGPK
DLFPYKEYKD KFGKSNKRKG FNEGLWEIEN NPGVKFTGYQ AIQQQSSSET EGEGGNTADA
SSEEEGDRVE EDGKGKRKNE KAGSKRKKSY TSKKSSKQSR KSPGDEDDKD CKEEENKSSS
EGGDAGNDTR NTTSDLQKTS EGT
