ID   ANFV_ACITR              Reviewed;         145 AA.
AC   P83962;
DT   05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Ventricular natriuretic peptide;
DE   Flags: Precursor;
GN   Name=vnp;
OS   Acipenser transmontanus (White sturgeon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Chondrostei; Acipenseriformes; Acipenseridae; Acipenser.
OX   NCBI_TaxID=7904;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Heart ventricle;
RX   PubMed=15072558; DOI=10.1677/jme.0.0320547;
RA   Kawakoshi A., Hyodo S., Inoue K., Kobayashi Y., Takei Y.;
RT   "Four natriuretic peptides (ANP, BNP, VNP and CNP) coexist in the sturgeon:
RT   identification of BNP in fish lineage.";
RL   J. Mol. Endocrinol. 32:547-555(2004).
CC   -!- FUNCTION: Exhibits natriuretic and vasodepressor activity.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Heart atrium and ventricle, and to a very low
CC       extent in brain. {ECO:0000269|PubMed:15072558}.
CC   -!- SIMILARITY: Belongs to the natriuretic peptide family. {ECO:0000305}.
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DR   EMBL; AB087730; BAD02837.1; -; mRNA.
DR   AlphaFoldDB; P83962; -.
DR   SMR; P83962; -.
DR   TCDB; 1.C.46.2.2; the c-type natriuretic peptide (cnp) family.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR000663; Natr_peptide.
DR   InterPro; IPR030480; Natr_peptide_CS.
DR   Pfam; PF00212; ANP; 1.
DR   SMART; SM00183; NAT_PEP; 1.
DR   PROSITE; PS00263; NATRIURETIC_PEPTIDE; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Secreted; Signal; Vasoactive.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   PROPEP          25..?
FT                   /id="PRO_0000001611"
FT   PEPTIDE         112..145
FT                   /note="Ventricular natriuretic peptide"
FT                   /id="PRO_0000001612"
FT   DISULFID        117..133
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   145 AA;  16390 MW;  9877CAD6CEBCD62B CRC64;
     MRMGKIAVGY GFLLLLVFQL GVRASTLFNK YNVQELSSLK DLLERLEEKL SPGEESDVYA
     GSEDLVNDPE EDADLILDNV RKQAEKEFYK PAGFRDENLQ RGRLRSIATS ARSMNGCFGN
     RIERIGSWSS LGCNNSRFGS KKRIF