ID   HDGR3_RAT               Reviewed;         202 AA.
AC   Q923W4;
DT   21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Hepatoma-derived growth factor-related protein 3;
DE            Short=HRP-3;
GN   Name=Hdgfl3; Synonyms=Hdgfrp3, Hrp3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Yu L.;
RL   Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-121; SER-122 AND SER-161, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: Enhances DNA synthesis and may play a role in cell
CC       proliferation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; AF389347; AAK72965.1; -; mRNA.
DR   RefSeq; NP_665728.1; NM_145785.1.
DR   AlphaFoldDB; Q923W4; -.
DR   BMRB; Q923W4; -.
DR   SMR; Q923W4; -.
DR   BioGRID; 251682; 1.
DR   STRING; 10116.ENSRNOP00000026754; -.
DR   iPTMnet; Q923W4; -.
DR   PhosphoSitePlus; Q923W4; -.
DR   jPOST; Q923W4; -.
DR   PaxDb; Q923W4; -.
DR   PRIDE; Q923W4; -.
DR   Ensembl; ENSRNOT00000026754; ENSRNOP00000026754; ENSRNOG00000019740.
DR   GeneID; 252941; -.
DR   KEGG; rno:252941; -.
DR   UCSC; RGD:628773; rat.
DR   CTD; 50810; -.
DR   RGD; 628773; Hdgfl3.
DR   eggNOG; KOG1904; Eukaryota.
DR   GeneTree; ENSGT00940000153942; -.
DR   HOGENOM; CLU_090867_1_0_1; -.
DR   InParanoid; Q923W4; -.
DR   OMA; CIRNPFA; -.
DR   OrthoDB; 530959at2759; -.
DR   PhylomeDB; Q923W4; -.
DR   PRO; PR:Q923W4; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000019740; Expressed in cerebellum and 20 other tissues.
DR   Genevisible; Q923W4; RN.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0015631; F:tubulin binding; ISS:UniProtKB.
DR   GO; GO:0046785; P:microtubule polymerization; ISS:UniProtKB.
DR   GO; GO:0007026; P:negative regulation of microtubule depolymerization; ISS:UniProtKB.
DR   GO; GO:0031175; P:neuron projection development; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd05834; HDGF_related; 1.
DR   InterPro; IPR035496; HDGF-rel_PWWP.
DR   InterPro; IPR000313; PWWP_dom.
DR   Pfam; PF00855; PWWP; 1.
DR   SMART; SM00293; PWWP; 1.
DR   PROSITE; PS50812; PWWP; 1.
PE   1: Evidence at protein level;
KW   Growth factor; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..202
FT                   /note="Hepatoma-derived growth factor-related protein 3"
FT                   /id="PRO_0000191705"
FT   DOMAIN          11..68
FT                   /note="PWWP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00162"
FT   REGION          90..202
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           135..147
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        94..117
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        121..138
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        139..154
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        157..180
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        181..202
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         110
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9JMG7"
FT   MOD_RES         121
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         122
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         161
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
SQ   SEQUENCE   202 AA;  22447 MW;  FCCDEBBD2BEAB8D6 CRC64;
     MARPRPREYK AGDLVFAKMK GYPHWPARID ELPEGAVKPP ANKYPIFFFG THETAFLGPK
     DLFPYKEYKD KFGKSNKRKG FNEGLWEIEN NPGVKFTGYQ TIQQQSSSET EGEGGNTADA
     SSEEEGDRVE DGKGKRKNEK GGSKRKKSYT SKKSSKQSRK SPGDEDDKDC KEEENKSSSE
     GGDAGNDTRN TTSDLQKAGE GT