ID   ANFV_ANGJA              Reviewed;         150 AA.
AC   P22642; Q9PSV2;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 2.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Ventricular natriuretic peptide;
DE            Short=VNP;
DE   Flags: Precursor;
GN   Name=vnp;
OS   Anguilla japonica (Japanese eel).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Anguilliformes; Anguillidae;
OC   Anguilla.
OX   NCBI_TaxID=7937;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Heart ventricle;
RX   PubMed=7893352; DOI=10.1677/jme.0.0130339;
RA   Takei Y., Ueki M., Nishizawa T.;
RT   "Eel ventricular natriuretic peptide: cDNA cloning and mRNA expression.";
RL   J. Mol. Endocrinol. 13:339-345(1994).
RN   [2]
RP   PROTEIN SEQUENCE OF 115-150, AND FUNCTION.
RC   TISSUE=Heart ventricle;
RX   PubMed=1828035; DOI=10.1016/0014-5793(91)80504-v;
RA   Takei Y., Takahashi A., Watanabe T.X., Nakajima K., Sakakibara S.;
RT   "A novel natriuretic peptide isolated from eel cardiac ventricles.";
RL   FEBS Lett. 282:317-320(1991).
CC   -!- FUNCTION: Exhibits natriuretic and vasodepressor activity.
CC       {ECO:0000269|PubMed:1828035}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Heart ventricle, and to a lower extent in heart
CC       atrium. {ECO:0000269|PubMed:7893352}.
CC   -!- SIMILARITY: Belongs to the natriuretic peptide family. {ECO:0000305}.
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DR   EMBL; AB019371; BAA34121.1; -; mRNA.
DR   PIR; S15821; S15821.
DR   AlphaFoldDB; P22642; -.
DR   SMR; P22642; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR000663; Natr_peptide.
DR   InterPro; IPR030480; Natr_peptide_CS.
DR   InterPro; IPR002407; Natriuretic_peptide_atrial.
DR   Pfam; PF00212; ANP; 1.
DR   PRINTS; PR00711; ANATPEPTIDE.
DR   SMART; SM00183; NAT_PEP; 1.
DR   PROSITE; PS00263; NATRIURETIC_PEPTIDE; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hormone; Secreted; Signal;
KW   Vasoactive.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..?
FT                   /id="PRO_0000001613"
FT   PEPTIDE         115..150
FT                   /note="Ventricular natriuretic peptide"
FT                   /id="PRO_0000001614"
FT   REGION          52..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        120..136
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   150 AA;  16735 MW;  919A097362C42519 CRC64;
     MAKSGIYLGC FILILIQNMV AANPLFNRNN VQELENLKDL IHQLEERVAV NEEPEVYPES
     EDMKMDAEEE DAGISPGALR QSEENLLMNI VDRIAPESPL RSRFRDLAGL AKTAKSFNSC
     FGTRMDRIGS WSGLGCNSLK NGTKKKIFGN