HDHD2_BOVIN
ID HDHD2_BOVIN Reviewed; 259 AA.
AC Q3ZCH9;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2005, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Haloacid dehalogenase-like hydrolase domain-containing protein 2;
GN Name=HDHD2;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000250};
CC -!- SIMILARITY: Belongs to the HAD-like hydrolase superfamily.
CC {ECO:0000305}.
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DR EMBL; BC102232; AAI02233.1; -; mRNA.
DR RefSeq; NP_001030194.1; NM_001035022.1.
DR RefSeq; XP_010817297.1; XM_010818995.1.
DR RefSeq; XP_015324658.1; XM_015469172.1.
DR AlphaFoldDB; Q3ZCH9; -.
DR SMR; Q3ZCH9; -.
DR STRING; 9913.ENSBTAP00000023026; -.
DR PaxDb; Q3ZCH9; -.
DR PeptideAtlas; Q3ZCH9; -.
DR PRIDE; Q3ZCH9; -.
DR Ensembl; ENSBTAT00000023026; ENSBTAP00000023026; ENSBTAG00000011893.
DR GeneID; 505403; -.
DR KEGG; bta:505403; -.
DR CTD; 84064; -.
DR VEuPathDB; HostDB:ENSBTAG00000011893; -.
DR VGNC; VGNC:108122; HDHD2.
DR eggNOG; KOG3040; Eukaryota.
DR GeneTree; ENSGT00940000155805; -.
DR HOGENOM; CLU_043473_4_3_1; -.
DR InParanoid; Q3ZCH9; -.
DR OMA; PNPYFFE; -.
DR OrthoDB; 1088513at2759; -.
DR Proteomes; UP000009136; Chromosome 24.
DR Bgee; ENSBTAG00000011893; Expressed in oocyte and 107 other tissues.
DR GO; GO:0019899; F:enzyme binding; ISS:CAFA.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016791; F:phosphatase activity; IBA:GO_Central.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd07509; HAD_PPase; 1.
DR Gene3D; 3.40.50.1000; -; 2.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR006357; HAD-SF_hydro_IIA.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR006355; LHPP/HDHD2.
DR Pfam; PF13344; Hydrolase_6; 1.
DR SUPFAM; SSF56784; SSF56784; 1.
DR TIGRFAMs; TIGR01460; HAD-SF-IIA; 1.
DR TIGRFAMs; TIGR01458; HAD-SF-IIA-hyp3; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Magnesium; Metal-binding; Reference proteome.
FT CHAIN 1..259
FT /note="Haloacid dehalogenase-like hydrolase domain-
FT containing protein 2"
FT /id="PRO_0000287202"
FT COILED 47..71
FT /evidence="ECO:0000255"
FT BINDING 13..15
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 13
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000250"
FT BINDING 15
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000250"
FT BINDING 46..47
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 179
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 204
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000250"
FT MOD_RES 50
FT /note="N6-succinyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q3UGR5"
SQ SEQUENCE 259 AA; 28594 MW; BB0D134CF7CB137F CRC64;
MATRRALKAV LVDLSGTLHI EDAAVPGAQE ALKRLRATSV MVRFVTNTTK ESKQDLLERL
KKLEFDISED EIFTSLTAAR NLVEQKQVRP MLLVDDRALP DFKGIQTSDP NAVVIGLAPE
HFHYQILNQA FRLLLDGAPL IAIHKARYYK RKDGLALGPG PFVTALEYAT DTKATVVGKP
EKTFFLEALR GTGCEPEETV MIGDDCRDDV GGAQNAGMRG ILVKTGKYRA ADEDKINPAP
YLTCESFPHA VDHILQHLL
