ID   HDHD2_DANRE             Reviewed;         262 AA.
AC   Q5BJJ5;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Haloacid dehalogenase-like hydrolase domain-containing protein 2;
GN   Name=hdhd2; ORFNames=zgc:110332;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Olfactory epithelium;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC       Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the HAD-like hydrolase superfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC091457; AAH91457.1; -; mRNA.
DR   RefSeq; NP_001013491.1; NM_001013473.1.
DR   AlphaFoldDB; Q5BJJ5; -.
DR   SMR; Q5BJJ5; -.
DR   STRING; 7955.ENSDARP00000039499; -.
DR   PaxDb; Q5BJJ5; -.
DR   DNASU; 541346; -.
DR   GeneID; 541346; -.
DR   KEGG; dre:541346; -.
DR   CTD; 84064; -.
DR   ZFIN; ZDB-GENE-050320-37; hdhd2.
DR   eggNOG; KOG3040; Eukaryota.
DR   InParanoid; Q5BJJ5; -.
DR   OrthoDB; 1088513at2759; -.
DR   PhylomeDB; Q5BJJ5; -.
DR   PRO; PR:Q5BJJ5; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016791; F:phosphatase activity; IBA:GO_Central.
DR   GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR   CDD; cd07509; HAD_PPase; 1.
DR   Gene3D; 3.40.50.1000; -; 2.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR006357; HAD-SF_hydro_IIA.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR006355; LHPP/HDHD2.
DR   Pfam; PF13344; Hydrolase_6; 1.
DR   SUPFAM; SSF56784; SSF56784; 1.
DR   TIGRFAMs; TIGR01460; HAD-SF-IIA; 1.
DR   TIGRFAMs; TIGR01458; HAD-SF-IIA-hyp3; 1.
PE   2: Evidence at transcript level;
KW   Magnesium; Metal-binding; Reference proteome.
FT   CHAIN           1..262
FT                   /note="Haloacid dehalogenase-like hydrolase domain-
FT                   containing protein 2"
FT                   /id="PRO_0000287207"
FT   BINDING         13..15
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         13
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         15
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         46..47
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         179
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         204
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   262 AA;  28546 MW;  78F709692679789F CRC64;
     MMARRTLKAV LIDLSGTLHI EDTAVPGAQE ALARLRQAPV AVKFVTNTTK ECKRTLFERL
     RGLNFDLQQQ EIFTSLTAAR NLVEQKAVRP LLMVEDSALE DFTGLETSDP NAVVIGLAPD
     HFNYQTLNKA FQLILDGAPL IAIHKARYYK KKDGLALGPG PFVTGLEYAT DTKATVVGKP
     EKGFFLEALR DLNCSPEEAV MIGDDARDDV GGAQNAGMLG ILVKTGKYRP ADEGKINPPP
     HLTCASFPEA VNYILDHLLG SK