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HDHD2_MOUSE
ID   HDHD2_MOUSE             Reviewed;         259 AA.
AC   Q3UGR5; Q3U8M0; Q6PEB2; Q9CXN1; Q9DCF2;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 2.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Haloacid dehalogenase-like hydrolase domain-containing protein 2;
GN   Name=Hdhd2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=C57BL/6J;
RC   TISSUE=Bone marrow, Head, Kidney, Melanocyte, and Urinary bladder;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PROTEIN SEQUENCE OF 9-33; 63-80 AND 183-190, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY.
RC   TISSUE=Hippocampus;
RA   Lubec G., Klug S.;
RL   Submitted (MAR-2007) to UniProtKB.
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC   Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [5]
RP   SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-50, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA   Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA   Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT   "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT   pathways.";
RL   Mol. Cell 50:919-930(2013).
RN   [6]
RP   X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 2-259 IN COMPLEX WITH MAGNESIUM
RP   AND PHOSPHATE IONS.
RG   Center for eukaryotic structural genomics (CESG);
RT   "Crystal structure of protein from mouse mm.236127.";
RL   Submitted (AUG-2006) to the PDB data bank.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC       Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000250};
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q3UGR5-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q3UGR5-2; Sequence=VSP_025374, VSP_025375;
CC   -!- SIMILARITY: Belongs to the HAD-like hydrolase superfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB22395.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AK002837; BAB22395.1; ALT_FRAME; mRNA.
DR   EMBL; AK014208; BAB29206.1; -; mRNA.
DR   EMBL; AK137285; BAE23293.1; -; mRNA.
DR   EMBL; AK147794; BAE28142.1; -; mRNA.
DR   EMBL; AK151285; BAE30270.1; -; mRNA.
DR   EMBL; AK152162; BAE30997.1; -; mRNA.
DR   EMBL; AK152259; BAE31078.1; -; mRNA.
DR   EMBL; BC058177; AAH58177.1; -; mRNA.
DR   CCDS; CCDS37863.1; -. [Q3UGR5-1]
DR   CCDS; CCDS37864.1; -. [Q3UGR5-2]
DR   RefSeq; NP_001034290.1; NM_001039201.1. [Q3UGR5-1]
DR   RefSeq; NP_001034291.1; NM_001039202.1. [Q3UGR5-2]
DR   RefSeq; NP_084102.1; NM_029826.2. [Q3UGR5-1]
DR   RefSeq; XP_006526505.1; XM_006526442.3.
DR   PDB; 2HO4; X-ray; 2.20 A; A/B=2-259.
DR   PDBsum; 2HO4; -.
DR   AlphaFoldDB; Q3UGR5; -.
DR   SMR; Q3UGR5; -.
DR   BioGRID; 218444; 5.
DR   IntAct; Q3UGR5; 1.
DR   MINT; Q3UGR5; -.
DR   STRING; 10090.ENSMUSP00000114212; -.
DR   iPTMnet; Q3UGR5; -.
DR   PhosphoSitePlus; Q3UGR5; -.
DR   EPD; Q3UGR5; -.
DR   jPOST; Q3UGR5; -.
DR   MaxQB; Q3UGR5; -.
DR   PaxDb; Q3UGR5; -.
DR   PeptideAtlas; Q3UGR5; -.
DR   PRIDE; Q3UGR5; -.
DR   ProteomicsDB; 269652; -. [Q3UGR5-1]
DR   ProteomicsDB; 269653; -. [Q3UGR5-2]
DR   Antibodypedia; 22539; 256 antibodies from 20 providers.
DR   DNASU; 76987; -.
DR   Ensembl; ENSMUST00000026485; ENSMUSP00000026485; ENSMUSG00000025421. [Q3UGR5-1]
DR   Ensembl; ENSMUST00000097521; ENSMUSP00000095128; ENSMUSG00000025421. [Q3UGR5-2]
DR   Ensembl; ENSMUST00000097522; ENSMUSP00000095129; ENSMUSG00000025421. [Q3UGR5-1]
DR   Ensembl; ENSMUST00000145634; ENSMUSP00000123320; ENSMUSG00000025421. [Q3UGR5-1]
DR   Ensembl; ENSMUST00000148955; ENSMUSP00000116243; ENSMUSG00000025421. [Q3UGR5-1]
DR   Ensembl; ENSMUST00000150990; ENSMUSP00000114212; ENSMUSG00000025421. [Q3UGR5-1]
DR   GeneID; 76987; -.
DR   KEGG; mmu:76987; -.
DR   UCSC; uc008fqs.1; mouse. [Q3UGR5-2]
DR   UCSC; uc008fqt.1; mouse. [Q3UGR5-1]
DR   CTD; 84064; -.
DR   MGI; MGI:1924237; Hdhd2.
DR   VEuPathDB; HostDB:ENSMUSG00000025421; -.
DR   eggNOG; KOG3040; Eukaryota.
DR   GeneTree; ENSGT00940000155805; -.
DR   HOGENOM; CLU_043473_4_0_1; -.
DR   InParanoid; Q3UGR5; -.
DR   OMA; PNPYFFE; -.
DR   OrthoDB; 1088513at2759; -.
DR   PhylomeDB; Q3UGR5; -.
DR   TreeFam; TF314344; -.
DR   BioGRID-ORCS; 76987; 0 hits in 72 CRISPR screens.
DR   ChiTaRS; Hdhd2; mouse.
DR   EvolutionaryTrace; Q3UGR5; -.
DR   PRO; PR:Q3UGR5; -.
DR   Proteomes; UP000000589; Chromosome 18.
DR   RNAct; Q3UGR5; protein.
DR   Bgee; ENSMUSG00000025421; Expressed in right kidney and 159 other tissues.
DR   Genevisible; Q3UGR5; MM.
DR   GO; GO:0019899; F:enzyme binding; ISS:CAFA.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016791; F:phosphatase activity; IBA:GO_Central.
DR   GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR   CDD; cd07509; HAD_PPase; 1.
DR   Gene3D; 3.40.50.1000; -; 2.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR006357; HAD-SF_hydro_IIA.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR006355; LHPP/HDHD2.
DR   Pfam; PF13344; Hydrolase_6; 1.
DR   SUPFAM; SSF56784; SSF56784; 1.
DR   TIGRFAMs; TIGR01460; HAD-SF-IIA; 1.
DR   TIGRFAMs; TIGR01458; HAD-SF-IIA-hyp3; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Alternative splicing; Coiled coil; Direct protein sequencing;
KW   Magnesium; Metal-binding; Reference proteome.
FT   CHAIN           1..259
FT                   /note="Haloacid dehalogenase-like hydrolase domain-
FT                   containing protein 2"
FT                   /id="PRO_0000287204"
FT   COILED          47..72
FT                   /evidence="ECO:0000255"
FT   BINDING         13..15
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         13
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000269|Ref.6"
FT   BINDING         15
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000269|Ref.6"
FT   BINDING         46..47
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         179
FT                   /ligand="substrate"
FT   BINDING         204
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         50
FT                   /note="N6-succinyllysine"
FT                   /evidence="ECO:0007744|PubMed:23806337"
FT   VAR_SEQ         133..145
FT                   /note="LLLDGAPLIAIHK -> RKQRGQEEENSDSH (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_025374"
FT   VAR_SEQ         146..259
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_025375"
FT   CONFLICT        52
FT                   /note="S -> T (in Ref. 2; AAH58177)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        57
FT                   /note="L -> P (in Ref. 1; BAB22395)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        146
FT                   /note="A -> T (in Ref. 1; BAE28142)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        238
FT                   /note="P -> S (in Ref. 1; BAB22395)"
FT                   /evidence="ECO:0000305"
FT   STRAND          9..18
FT                   /evidence="ECO:0007829|PDB:2HO4"
FT   HELIX           28..36
FT                   /evidence="ECO:0007829|PDB:2HO4"
FT   STRAND          41..46
FT                   /evidence="ECO:0007829|PDB:2HO4"
FT   HELIX           53..62
FT                   /evidence="ECO:0007829|PDB:2HO4"
FT   HELIX           69..71
FT                   /evidence="ECO:0007829|PDB:2HO4"
FT   STRAND          72..74
FT                   /evidence="ECO:0007829|PDB:2HO4"
FT   HELIX           75..86
FT                   /evidence="ECO:0007829|PDB:2HO4"
FT   STRAND          90..94
FT                   /evidence="ECO:0007829|PDB:2HO4"
FT   HELIX           96..102
FT                   /evidence="ECO:0007829|PDB:2HO4"
FT   STRAND          112..115
FT                   /evidence="ECO:0007829|PDB:2HO4"
FT   HELIX           119..121
FT                   /evidence="ECO:0007829|PDB:2HO4"
FT   HELIX           124..135
FT                   /evidence="ECO:0007829|PDB:2HO4"
FT   STRAND          140..143
FT                   /evidence="ECO:0007829|PDB:2HO4"
FT   STRAND          147..151
FT                   /evidence="ECO:0007829|PDB:2HO4"
FT   STRAND          154..157
FT                   /evidence="ECO:0007829|PDB:2HO4"
FT   HELIX           160..170
FT                   /evidence="ECO:0007829|PDB:2HO4"
FT   HELIX           182..188
FT                   /evidence="ECO:0007829|PDB:2HO4"
FT   HELIX           189..192
FT                   /evidence="ECO:0007829|PDB:2HO4"
FT   HELIX           196..198
FT                   /evidence="ECO:0007829|PDB:2HO4"
FT   STRAND          199..204
FT                   /evidence="ECO:0007829|PDB:2HO4"
FT   TURN            206..209
FT                   /evidence="ECO:0007829|PDB:2HO4"
FT   HELIX           210..215
FT                   /evidence="ECO:0007829|PDB:2HO4"
FT   STRAND          219..225
FT                   /evidence="ECO:0007829|PDB:2HO4"
FT   HELIX           232..235
FT                   /evidence="ECO:0007829|PDB:2HO4"
FT   STRAND          236..238
FT                   /evidence="ECO:0007829|PDB:2HO4"
FT   STRAND          241..245
FT                   /evidence="ECO:0007829|PDB:2HO4"
FT   HELIX           247..257
FT                   /evidence="ECO:0007829|PDB:2HO4"
SQ   SEQUENCE   259 AA;  28730 MW;  C8E34D5F0D6C9AE8 CRC64;
     MAARRALKAV LVDLNGTLHI EDAAVPGAQE ALKRLRATSV MVRFVTNTTK ESKKDLLERL
     KKLEFEISED EIFTSLTAAR NLIEQKQVRP MLLVDDRALP EFTGVQTQDP NAVVIGLAPE
     HFHYQLLNQA FRLLLDGAPL IAIHKARYYK RKDGLALGPG PFVTALEYAT DTKAMVVGKP
     EKTFFLEALR DADCAPEEAV MIGDDCRDDV DGAQNIGMLG ILVKTGKYKA ADEEKINPPP
     YLTCESFPHA VDHILQHLL
 
 
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