ID   HDHD2_PONAB             Reviewed;         259 AA.
AC   Q5R4B4;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Haloacid dehalogenase-like hydrolase domain-containing protein 2;
GN   Name=HDHD2;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC       Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the HAD-like hydrolase superfamily.
CC       {ECO:0000305}.
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DR   EMBL; CR861339; CAH93402.1; -; mRNA.
DR   RefSeq; NP_001127661.1; NM_001134189.1.
DR   AlphaFoldDB; Q5R4B4; -.
DR   SMR; Q5R4B4; -.
DR   STRING; 9601.ENSPPYP00000010269; -.
DR   GeneID; 100174743; -.
DR   KEGG; pon:100174743; -.
DR   CTD; 84064; -.
DR   eggNOG; KOG3040; Eukaryota.
DR   HOGENOM; CLU_043473_4_0_1; -.
DR   InParanoid; Q5R4B4; -.
DR   OMA; PNPYFFE; -.
DR   OrthoDB; 1088513at2759; -.
DR   TreeFam; TF314344; -.
DR   Proteomes; UP000001595; Chromosome 18.
DR   GO; GO:0019899; F:enzyme binding; ISS:CAFA.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016791; F:phosphatase activity; IEA:InterPro.
DR   GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR   CDD; cd07509; HAD_PPase; 1.
DR   Gene3D; 3.40.50.1000; -; 2.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR006357; HAD-SF_hydro_IIA.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR006355; LHPP/HDHD2.
DR   Pfam; PF13344; Hydrolase_6; 1.
DR   SUPFAM; SSF56784; SSF56784; 1.
DR   TIGRFAMs; TIGR01460; HAD-SF-IIA; 1.
DR   TIGRFAMs; TIGR01458; HAD-SF-IIA-hyp3; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Magnesium; Metal-binding; Reference proteome.
FT   CHAIN           1..259
FT                   /note="Haloacid dehalogenase-like hydrolase domain-
FT                   containing protein 2"
FT                   /id="PRO_0000287205"
FT   COILED          47..71
FT                   /evidence="ECO:0000255"
FT   BINDING         13..15
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         13
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         15
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         46..47
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         179
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         204
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         50
FT                   /note="N6-succinyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UGR5"
SQ   SEQUENCE   259 AA;  28538 MW;  982CCE54792CD4C0 CRC64;
     MAACRALKAV LVDLSGTLHI EDAAVPGAQE ALKRLRGTSV IVRFVTNTTK ESKQDLLERL
     RKLEFDISED EIFTSLTAAR SLLEQKQVRP MLLVDDRALP DFKGIQTTDP NAVVMGLAPE
     HFHYQILNQA FRLLLDGAPL IAIHKARYYK RKDGLALGPG PFVTALEYAT DTKATVVGKP
     EKTFFLEALR GTGCEPEEAV MIGDDCRDDV GGAQDVGMLG ILVKTGKYRA SDEEKINPPP
     YLTCESFPHA VDHILQHLL