ID   HDHD2_RAT               Reviewed;         259 AA.
AC   Q6AYR6;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Haloacid dehalogenase-like hydrolase domain-containing protein 2;
GN   Name=Hdhd2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC       Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the HAD-like hydrolase superfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC078941; AAH78941.1; -; mRNA.
DR   RefSeq; XP_006255027.1; XM_006254965.3.
DR   RefSeq; XP_006255028.1; XM_006254966.3.
DR   AlphaFoldDB; Q6AYR6; -.
DR   SMR; Q6AYR6; -.
DR   STRING; 10116.ENSRNOP00000039553; -.
DR   iPTMnet; Q6AYR6; -.
DR   PhosphoSitePlus; Q6AYR6; -.
DR   SwissPalm; Q6AYR6; -.
DR   PaxDb; Q6AYR6; -.
DR   PRIDE; Q6AYR6; -.
DR   Ensembl; ENSRNOT00000080660; ENSRNOP00000075095; ENSRNOG00000043171.
DR   GeneID; 361351; -.
DR   CTD; 84064; -.
DR   RGD; 1308579; Hdhd2.
DR   eggNOG; KOG3040; Eukaryota.
DR   eggNOG; KOG4779; Eukaryota.
DR   GeneTree; ENSGT00940000155805; -.
DR   HOGENOM; CLU_043473_4_0_1; -.
DR   InParanoid; Q6AYR6; -.
DR   OMA; PNPYFFE; -.
DR   PRO; PR:Q6AYR6; -.
DR   Proteomes; UP000002494; Chromosome 18.
DR   Bgee; ENSRNOG00000043171; Expressed in ovary and 19 other tissues.
DR   ExpressionAtlas; Q6AYR6; baseline and differential.
DR   Genevisible; Q6AYR6; RN.
DR   GO; GO:0019899; F:enzyme binding; ISS:CAFA.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016791; F:phosphatase activity; IBA:GO_Central.
DR   GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR   CDD; cd07509; HAD_PPase; 1.
DR   Gene3D; 3.40.50.1000; -; 2.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR006357; HAD-SF_hydro_IIA.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR006355; LHPP/HDHD2.
DR   Pfam; PF13344; Hydrolase_6; 1.
DR   SUPFAM; SSF56784; SSF56784; 1.
DR   TIGRFAMs; TIGR01460; HAD-SF-IIA; 1.
DR   TIGRFAMs; TIGR01458; HAD-SF-IIA-hyp3; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Magnesium; Metal-binding; Reference proteome.
FT   CHAIN           1..259
FT                   /note="Haloacid dehalogenase-like hydrolase domain-
FT                   containing protein 2"
FT                   /id="PRO_0000287206"
FT   COILED          49..71
FT                   /evidence="ECO:0000255"
FT   BINDING         13..15
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         13
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         15
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         46..47
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         179
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         204
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         50
FT                   /note="N6-succinyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UGR5"
SQ   SEQUENCE   259 AA;  28779 MW;  58393FCA893C7991 CRC64;
     MAARRVLKAV LVDLSGTLHI EDAAVPGAQE ALKRLRAASV MVRFVTNTTK ESKRDLLERL
     RKLEFDISEE EIFTSLTAAR NLIEQRQVRP MLLVDDRALP DFTGVQTHDP NAVVIGLAPE
     HFHYQLLNEA FRLLLDGAPL IAIHKARYYK RKDGLALGPG PFVTALEYAT DTKAVVVGKP
     EKTFFLEALR DTDCAPEEAV MIGDDCRDDV DGAQNIGMLG ILVKTGKYKA ADEEKINPPP
     YLTCESFPHA VDHILQHLL