ID   HDHD5_MOUSE             Reviewed;         419 AA.
AC   Q91WM2;
DT   16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Haloacid dehalogenase-like hydrolase domain-containing 5 {ECO:0000312|MGI:MGI:2136976};
DE   AltName: Full=Cat eye syndrome critical region protein 5 homolog {ECO:0000305};
DE   Flags: Precursor;
GN   Name=Hdhd5 {ECO:0000312|MGI:MGI:2136976};
GN   Synonyms=Cecr5 {ECO:0000312|MGI:MGI:2136976};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brown adipose tissue, Heart, Kidney, Liver, Pancreas, Spleen, and
RC   Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SIMILARITY: Belongs to the HAD-like hydrolase superfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC014705; AAH14705.1; -; mRNA.
DR   CCDS; CCDS20483.1; -.
DR   RefSeq; NP_659064.1; NM_144815.2.
DR   AlphaFoldDB; Q91WM2; -.
DR   SMR; Q91WM2; -.
DR   BioGRID; 229577; 1.
DR   STRING; 10090.ENSMUSP00000074775; -.
DR   iPTMnet; Q91WM2; -.
DR   PhosphoSitePlus; Q91WM2; -.
DR   REPRODUCTION-2DPAGE; Q91WM2; -.
DR   EPD; Q91WM2; -.
DR   jPOST; Q91WM2; -.
DR   MaxQB; Q91WM2; -.
DR   PaxDb; Q91WM2; -.
DR   PeptideAtlas; Q91WM2; -.
DR   PRIDE; Q91WM2; -.
DR   ProteomicsDB; 269654; -.
DR   Antibodypedia; 257; 119 antibodies from 21 providers.
DR   Ensembl; ENSMUST00000075303; ENSMUSP00000074775; ENSMUSG00000058979.
DR   GeneID; 214932; -.
DR   KEGG; mmu:214932; -.
DR   UCSC; uc009dnl.1; mouse.
DR   CTD; 27440; -.
DR   MGI; MGI:2136976; Hdhd5.
DR   VEuPathDB; HostDB:ENSMUSG00000058979; -.
DR   eggNOG; KOG1618; Eukaryota.
DR   GeneTree; ENSGT00390000018051; -.
DR   HOGENOM; CLU_030880_0_1_1; -.
DR   InParanoid; Q91WM2; -.
DR   OMA; CTSILVC; -.
DR   OrthoDB; 418243at2759; -.
DR   PhylomeDB; Q91WM2; -.
DR   TreeFam; TF313681; -.
DR   BioGRID-ORCS; 214932; 1 hit in 73 CRISPR screens.
DR   PRO; PR:Q91WM2; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   RNAct; Q91WM2; protein.
DR   Bgee; ENSMUSG00000058979; Expressed in interventricular septum and 114 other tissues.
DR   Genevisible; Q91WM2; MM.
DR   GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR   GO; GO:0046474; P:glycerophospholipid biosynthetic process; IBA:GO_Central.
DR   Gene3D; 3.40.50.1000; -; 2.
DR   InterPro; IPR029621; CECR5.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR006357; HAD-SF_hydro_IIA.
DR   InterPro; IPR006353; HAD-SF_hydro_IIA_CECR5.
DR   InterPro; IPR023214; HAD_sf.
DR   PANTHER; PTHR14269:SF17; PTHR14269:SF17; 1.
DR   Pfam; PF13344; Hydrolase_6; 1.
DR   SUPFAM; SSF56784; SSF56784; 1.
DR   TIGRFAMs; TIGR01456; CECR5; 1.
DR   TIGRFAMs; TIGR01460; HAD-SF-IIA; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..419
FT                   /note="Haloacid dehalogenase-like hydrolase domain-
FT                   containing 5"
FT                   /id="PRO_0000020921"
SQ   SEQUENCE   419 AA;  46306 MW;  2ED2EDB490AF9348 CRC64;
     MAALAGLGVL GAGRHLWKLP VRLSAGLQGC GPRRGYIAGS AERSPTFGLL FDIDGVLVRG
     HRVIPAALEA FSKLVNSQGQ LRVPVVFVTN AGNILQHNKA QELSDLLRCK VDPDQVILSH
     SPMKLFLQYH SKQMLVSGQG PLVENARALG FQNVVTIDEL RLAFPELDMV DLQRRPKTMR
     LRSDFPAIEG VLLLGEPVRW ETNLQLIMDV LLSNGHPGTG LATAPYPHLP VLASNMDLLW
     MAEAKMPRFG HGTFLLCLET IYRKITGNEL KYEGLMGKPS ILTYQYAEDV IRQQAERRGW
     AAPIRKLYAI GDNPMSDVYG ANLFHQYLQM ANRGEEEQQT GGQQKQRPSA TQSCASILVC
     TGIYSSQDPG SQVPPPGRRE LPFHGHRDFS FSPGLLEASH IVHDVNEAVQ LVFHQEGWA