ID   ANF_ANGJA               Reviewed;          27 AA.
AC   P18144;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Natriuretic peptides A;
DE   AltName: Full=Prepronatriodilatin;
DE   Contains:
DE     RecName: Full=Atrial natriuretic factor;
DE              Short=ANF;
DE     AltName: Full=Atrial natriuretic peptide;
DE              Short=ANP;
GN   Name=nppa;
OS   Anguilla japonica (Japanese eel).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Anguilliformes; Anguillidae;
OC   Anguilla.
OX   NCBI_TaxID=7937;
RN   [1]
RP   PROTEIN SEQUENCE, AND DISULFIDE BOND.
RC   TISSUE=Heart atrium;
RX   PubMed=2529857; DOI=10.1016/0006-291x(89)91752-x;
RA   Takei Y., Takahashi A., Watanabe T.X., Nakajima K., Sakakibara S.;
RT   "Amino acid sequence and relative biological activity of eel atrial
RT   natriuretic peptide.";
RL   Biochem. Biophys. Res. Commun. 164:537-543(1989).
CC   -!- FUNCTION: Hormone playing a key role in cardiovascular homeostasis
CC       through regulation of natriuresis, diuresis, and vasodilation. Has a
CC       cGMP-stimulating activity (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the natriuretic peptide family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PIR; A33431; A33431.
DR   AlphaFoldDB; P18144; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0006182; P:cGMP biosynthetic process; ISS:GO_Central.
DR   GO; GO:0007168; P:receptor guanylyl cyclase signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR000663; Natr_peptide.
DR   InterPro; IPR030480; Natr_peptide_CS.
DR   InterPro; IPR002408; Natriuretic_peptide_brain.
DR   Pfam; PF00212; ANP; 1.
DR   PRINTS; PR00712; BNATPEPTIDE.
DR   PRINTS; PR00710; NATPEPTIDES.
DR   SMART; SM00183; NAT_PEP; 1.
DR   PROSITE; PS00263; NATRIURETIC_PEPTIDE; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hormone; Secreted; Vasoactive.
FT   PEPTIDE         1..27
FT                   /note="Atrial natriuretic factor"
FT                   /evidence="ECO:0000269|PubMed:2529857"
FT                   /id="PRO_0000043485"
FT   DISULFID        7..23
FT                   /evidence="ECO:0000269|PubMed:2529857"
SQ   SEQUENCE   27 AA;  2792 MW;  9EF5100CCF282B4D CRC64;
     SKSSSPCFGG KLDRIGSYSG LGCNSRK