ID   ANF_CHICK               Reviewed;         140 AA.
AC   P18908;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 2.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Natriuretic peptides A;
DE   AltName: Full=Prepronatriodilatin;
DE   Contains:
DE     RecName: Full=Atrial natriuretic factor;
DE              Short=ANF;
DE     AltName: Full=Atrial natriuretic peptide;
DE              Short=ANP;
DE   Flags: Precursor;
GN   Name=NPPA;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1826483; DOI=10.1016/0014-5793(91)80331-v;
RA   Akizuki N., Kangawa K., Minamino N., Matsuo H.;
RT   "Cloning and sequence analysis of complementary DNA encoding a precursor
RT   for chicken natriuretic peptide.";
RL   FEBS Lett. 280:357-362(1991).
RN   [2]
RP   PROTEIN SEQUENCE OF 112-140.
RC   TISSUE=Heart;
RX   PubMed=2972278; DOI=10.1016/s0006-291x(88)81287-7;
RA   Miyata A., Minamino N., Kangawa K., Matsuo H.;
RT   "Identification of a 29-amino acid natriuretic peptide in chicken heart.";
RL   Biochem. Biophys. Res. Commun. 155:1330-1337(1988).
CC   -!- FUNCTION: Hormone playing a key role in cardiovascular homeostasis
CC       through regulation of natriuresis, diuresis, and vasodilation.
CC       Specifically binds and stimulates the cGMP production of the NPR1
CC       receptor. Binds the clearance receptor NPR3 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: Cleaved by CORIN upon secretion to produce the functional hormone.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the natriuretic peptide family. {ECO:0000305}.
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DR   EMBL; X57702; CAA40879.1; -; mRNA.
DR   PIR; S14320; S14320.
DR   RefSeq; NP_990256.1; NM_204925.1.
DR   AlphaFoldDB; P18908; -.
DR   SMR; P18908; -.
DR   STRING; 9031.ENSGALP00000034287; -.
DR   PaxDb; P18908; -.
DR   Ensembl; ENSGALT00000034931; ENSGALP00000034287; ENSGALG00000004574.
DR   GeneID; 395765; -.
DR   KEGG; gga:395765; -.
DR   CTD; 4878; -.
DR   VEuPathDB; HostDB:geneid_395765; -.
DR   eggNOG; ENOG502SD0X; Eukaryota.
DR   GeneTree; ENSGT00940000154513; -.
DR   HOGENOM; CLU_158067_0_0_1; -.
DR   InParanoid; P18908; -.
DR   OMA; PTGVWKA; -.
DR   OrthoDB; 1493586at2759; -.
DR   PhylomeDB; P18908; -.
DR   TreeFam; TF106304; -.
DR   PRO; PR:P18908; -.
DR   Proteomes; UP000000539; Chromosome 21.
DR   Bgee; ENSGALG00000004574; Expressed in heart and 4 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0051427; F:hormone receptor binding; IBA:GO_Central.
DR   GO; GO:0006182; P:cGMP biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0019934; P:cGMP-mediated signaling; IBA:GO_Central.
DR   GO; GO:0009792; P:embryo development ending in birth or egg hatching; IEP:AgBase.
DR   GO; GO:0003085; P:negative regulation of systemic arterial blood pressure; IBA:GO_Central.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR   GO; GO:0007168; P:receptor guanylyl cyclase signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR000663; Natr_peptide.
DR   InterPro; IPR030480; Natr_peptide_CS.
DR   InterPro; IPR002408; Natriuretic_peptide_brain.
DR   Pfam; PF00212; ANP; 1.
DR   PRINTS; PR00712; BNATPEPTIDE.
DR   PRINTS; PR00710; NATPEPTIDES.
DR   SMART; SM00183; NAT_PEP; 1.
DR   PROSITE; PS00263; NATRIURETIC_PEPTIDE; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hormone; Reference proteome;
KW   Secreted; Signal; Vasoactive.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000250|UniProtKB:P24259"
FT   PROPEP          25..111
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000001513"
FT   PEPTIDE         112..140
FT                   /note="Atrial natriuretic factor"
FT                   /evidence="ECO:0000269|PubMed:2972278"
FT                   /id="PRO_0000001514"
FT   REGION          55..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            111..112
FT                   /note="Cleavage; by CORIN"
FT                   /evidence="ECO:0000305|PubMed:2972278"
FT   DISULFID        118..134
FT                   /evidence="ECO:0000269|PubMed:2972278"
SQ   SEQUENCE   140 AA;  15714 MW;  67FEBFE094E71F40 CRC64;
     MDTRGSFSCG FLLLLLIQLQ PSRANPIYNL SPAKELASME ALLERLEDKF ALIEALESNP
     DLQEPQTQEE IPPELTDDSD EQKAEPKLAS NTPLSYRNPF LKRLRGVQMP RMMRDSGCFG
     RRIDRIGSLS GMGCNGSRKN