ID   HDRB2_METJA             Reviewed;         295 AA.
AC   Q58273;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=CoB--CoM heterodisulfide reductase subunit B 2 {ECO:0000305};
DE            EC=1.8.98.- {ECO:0000305};
GN   Name=hdrB2; OrderedLocusNames=MJ0863;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- FUNCTION: Part of a complex that catalyzes the reversible reduction of
CC       CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB
CC       (coenzyme B). {ECO:0000250|UniProtKB:Q6LY38}.
CC   -!- PATHWAY: Cofactor metabolism; coenzyme M-coenzyme B heterodisulfide
CC       reduction; coenzyme B and coenzyme M from coenzyme M-coenzyme B
CC       heterodisulfide: step 1/1. {ECO:0000250|UniProtKB:Q6LY38}.
CC   -!- SUBUNIT: The heterodisulfide reductase is composed of three subunits;
CC       HdrA, HdrB and HdrC. {ECO:0000250|UniProtKB:Q6LY38}.
CC   -!- SIMILARITY: Belongs to the HdrB family. {ECO:0000305}.
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DR   EMBL; L77117; AAB98868.1; -; Genomic_DNA.
DR   PIR; G64407; G64407.
DR   RefSeq; WP_010870378.1; NC_000909.1.
DR   AlphaFoldDB; Q58273; -.
DR   SMR; Q58273; -.
DR   STRING; 243232.MJ_0863; -.
DR   EnsemblBacteria; AAB98868; AAB98868; MJ_0863.
DR   GeneID; 1451752; -.
DR   KEGG; mja:MJ_0863; -.
DR   eggNOG; arCOG00338; Archaea.
DR   HOGENOM; CLU_052147_1_0_2; -.
DR   InParanoid; Q58273; -.
DR   OMA; YMPGASC; -.
DR   OrthoDB; 73750at2157; -.
DR   PhylomeDB; Q58273; -.
DR   UniPathway; UPA00647; UER00700.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0051912; F:CoB--CoM heterodisulfide reductase activity; IEA:InterPro.
DR   GO; GO:0015948; P:methanogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR017678; CoB/CoM_hetero-S_Rdtase_bsu.
DR   InterPro; IPR004017; Cys_rich_dom.
DR   Pfam; PF02754; CCG; 2.
DR   TIGRFAMs; TIGR03288; CoB_CoM_SS_B; 1.
PE   3: Inferred from homology;
KW   Methanogenesis; Oxidoreductase; Reference proteome.
FT   CHAIN           1..295
FT                   /note="CoB--CoM heterodisulfide reductase subunit B 2"
FT                   /id="PRO_0000150066"
SQ   SEQUENCE   295 AA;  32789 MW;  35A2A278491E8ED0 CRC64;
     MKYAFFLGCI MPHRYPGVEK ATKIVMEELG VELEYMPGAS CCPAPGVFGS FDQKTWLTLA
     ARNLCIAEEM GLDIVTVCNG CYGSLFEAAH ILHENKEALD FVNEKLDKIG KQYKGTIKVR
     HFAELIYKDI GVDKIKEKVV KPLDVLNVAI HYGCHFLKPS DVKHLDSPER PKLLEEIVAA
     TGAKPVMYRD YLMCCGAGGG VRARFLPTAL DMTKEKIRNM LEAGADCTVN VCPFCHLQFD
     RGQVEIKEKF GEEYKLPVLH LSQLLGLAFG MKPEDLAVSV HAIPVDPVLK KLGIE