ID   ANF_CRODC               Reviewed;          33 AA.
AC   P0DKY6;
DT   06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2013, sequence version 1.
DT   25-MAY-2022, entry version 13.
DE   RecName: Full=Natriuretic peptide NP2;
DE   AltName: Full=NP2_Casca;
OS   Crotalus durissus cascavella (Northeastern Brazilian rattlesnake).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Crotalinae; Crotalus.
OX   NCBI_TaxID=184540;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, AND MASS SPECTROMETRY.
RX   PubMed=18835291; DOI=10.1016/j.toxicon.2008.08.014;
RA   Evangelista J.S., Martins A.M., Nascimento N.R., Sousa C.M., Alves R.S.,
RA   Toyama D.O., Toyama M.H., Evangelista J.J., Menezes D.B., Fonteles M.C.,
RA   Moraes M.E., Monteiro H.S.;
RT   "Renal and vascular effects of the natriuretic peptide isolated from
RT   Crotalus durissus cascavella venom.";
RL   Toxicon 52:737-744(2008).
CC   -!- FUNCTION: Snake venom natriuretic peptide that shows an increase in
CC       perfusion pressure, urinary flow and glomerular filtration rate.
CC       Reduces total and proximal tubular transport of sodium. In the aortic
CC       ring assay, causes a relaxant effect in endothelium-intact thoracic
CC       aortic rings precontracted with phenylephrine in the presence and
CC       absence of isatin, a natriuretic receptor antagonist.
CC       {ECO:0000269|PubMed:18835291}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- MASS SPECTROMETRY: Mass=3453.94; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:18835291};
CC   -!- SIMILARITY: Belongs to the natriuretic peptide family. {ECO:0000305}.
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DR   AlphaFoldDB; P0DKY6; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
DR   GO; GO:0042311; P:vasodilation; IEA:UniProtKB-KW.
DR   InterPro; IPR000663; Natr_peptide.
DR   InterPro; IPR030480; Natr_peptide_CS.
DR   Pfam; PF00212; ANP; 1.
DR   PRINTS; PR00710; NATPEPTIDES.
DR   SMART; SM00183; NAT_PEP; 1.
DR   PROSITE; PS00263; NATRIURETIC_PEPTIDE; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hypotensive agent; Secreted;
KW   Toxin; Vasoactive; Vasodilator.
FT   CHAIN           1..33
FT                   /note="Natriuretic peptide NP2"
FT                   /id="PRO_0000421799"
FT   DISULFID        10..26
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   33 AA;  3454 MW;  1A154B5ADE0CB9EC CRC64;
     VSTSRGSQGC FGLKLDRIGA ASGLGCWRRI VDS