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HDRB_METKA
ID   HDRB_METKA              Reviewed;         305 AA.
AC   Q8TXT8;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=CoB--CoM heterodisulfide reductase subunit B {ECO:0000305};
DE            EC=1.8.98.- {ECO:0000305};
GN   Name=hdrB; OrderedLocusNames=MK0572;
OS   Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938).
OC   Archaea; Euryarchaeota; Methanopyri; Methanopyrales; Methanopyraceae;
OC   Methanopyrus.
OX   NCBI_TaxID=190192;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AV19 / DSM 6324 / JCM 9639 / NBRC 100938;
RX   PubMed=11930014; DOI=10.1073/pnas.032671499;
RA   Slesarev A.I., Mezhevaya K.V., Makarova K.S., Polushin N.N.,
RA   Shcherbinina O.V., Shakhova V.V., Belova G.I., Aravind L., Natale D.A.,
RA   Rogozin I.B., Tatusov R.L., Wolf Y.I., Stetter K.O., Malykh A.G.,
RA   Koonin E.V., Kozyavkin S.A.;
RT   "The complete genome of hyperthermophile Methanopyrus kandleri AV19 and
RT   monophyly of archaeal methanogens.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:4644-4649(2002).
CC   -!- FUNCTION: Part of a complex that catalyzes the reversible reduction of
CC       CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB
CC       (coenzyme B). {ECO:0000250|UniProtKB:Q6LY38}.
CC   -!- PATHWAY: Cofactor metabolism; coenzyme M-coenzyme B heterodisulfide
CC       reduction; coenzyme B and coenzyme M from coenzyme M-coenzyme B
CC       heterodisulfide: step 1/1. {ECO:0000250|UniProtKB:Q6LY38}.
CC   -!- SUBUNIT: The heterodisulfide reductase is composed of three subunits;
CC       HdrA, HdrB and HdrC. {ECO:0000250|UniProtKB:Q6LY38}.
CC   -!- SIMILARITY: Belongs to the HdrB family. {ECO:0000305}.
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DR   EMBL; AE009439; AAM01787.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8TXT8; -.
DR   SMR; Q8TXT8; -.
DR   STRING; 190192.MK0572; -.
DR   EnsemblBacteria; AAM01787; AAM01787; MK0572.
DR   KEGG; mka:MK0572; -.
DR   PATRIC; fig|190192.8.peg.607; -.
DR   HOGENOM; CLU_052147_1_0_2; -.
DR   OMA; PGCVAQG; -.
DR   UniPathway; UPA00647; UER00700.
DR   Proteomes; UP000001826; Chromosome.
DR   GO; GO:0051912; F:CoB--CoM heterodisulfide reductase activity; IEA:InterPro.
DR   GO; GO:0015948; P:methanogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR017678; CoB/CoM_hetero-S_Rdtase_bsu.
DR   InterPro; IPR004017; Cys_rich_dom.
DR   Pfam; PF02754; CCG; 2.
DR   TIGRFAMs; TIGR03288; CoB_CoM_SS_B; 1.
PE   3: Inferred from homology;
KW   Methanogenesis; Oxidoreductase; Reference proteome.
FT   CHAIN           1..305
FT                   /note="CoB--CoM heterodisulfide reductase subunit B"
FT                   /id="PRO_0000150067"
SQ   SEQUENCE   305 AA;  34131 MW;  A23028DA7A976AAA CRC64;
     MAKKLCFFLG CIMPNRYPGI EKATRLVFEE LGYELVDMDG ASCCPAPGVF GSFDLKTWVT
     IAARNLSIAE EKGYDILTVC NGCFGSLNEA NHLLQENPEL REFVNEKLAE IDREYKGKVK
     VYHVNTFLYE EVGVKKIKEK VERPLEKTDG EPLKVAVHYG CHLLKPSEVT GFPGSVEDPR
     TLDELVEALG AESVDYKDKI MCCGAGGGVR SRELKVSLHF TREKIFNMLE AGADCTTNVC
     PFCHLQFDRG QIEMKEHFEK LPPKKLPVFH YCQLAGLAFG MDPEELALET HEIDCTPVLE
     KLGLA
 
 
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