HDT1_SOYBN
ID HDT1_SOYBN Reviewed; 295 AA.
AC Q8LJS2;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Histone deacetylase HDT1;
DE AltName: Full=Histone deacetylase 2a;
DE Short=HD2a;
DE AltName: Full=Nucleolar histone deacetylase HD2-p39;
GN Name=HDT1; Synonyms=HD2A;
OS Glycine max (Soybean) (Glycine hispida).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Glycine;
OC Glycine subgen. Soja.
OX NCBI_TaxID=3847;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Seed coat;
RA Tang T.J., Wang C.S.;
RT "Nucleotide sequence of a cDNA encoding soybean nucleolar histone
RT deacetylase HD2-p39.";
RL Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates the deacetylation of lysine residues on the N-
CC terminal part of the core histones (H2A, H2B, H3 and H4). Histone
CC deacetylation gives a tag for epigenetic repression and plays an
CC important role in transcriptional regulation, cell cycle progression
CC and developmental events (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the histone deacetylase HD2 family.
CC {ECO:0000305}.
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DR EMBL; AF532618; AAN03465.1; -; mRNA.
DR RefSeq; NP_001235884.1; NM_001248955.1.
DR AlphaFoldDB; Q8LJS2; -.
DR SMR; Q8LJS2; -.
DR STRING; 3847.GLYMA12G09000.1; -.
DR PRIDE; Q8LJS2; -.
DR GeneID; 547649; -.
DR KEGG; gmx:547649; -.
DR eggNOG; ENOG502QVH6; Eukaryota.
DR InParanoid; Q8LJS2; -.
DR OrthoDB; 1260281at2759; -.
DR Proteomes; UP000008827; Unplaced.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0010162; P:seed dormancy process; IBA:GO_Central.
DR InterPro; IPR041232; NPL.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF17800; NPL; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 2: Evidence at transcript level;
KW Chromatin regulator; Hydrolase; Metal-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Repressor; Transcription; Transcription regulation;
KW Zinc; Zinc-finger.
FT CHAIN 1..295
FT /note="Histone deacetylase HDT1"
FT /id="PRO_0000195212"
FT ZN_FING 269..292
FT /note="C2H2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 105..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..135
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..197
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..213
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..242
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 295 AA; 31354 MW; 63B4B45832CAA039 CRC64;
MEFWGVEVKV GQTVTVDPMD PVDSYIHISQ VALGEAKKDK PNEPVVLYLK VGEQKIVLGT
LSRDGIPHLS LDLVLDSDSE LSHTSKSASV FFCGYKVLTG NDNASDFSDS SEEDEELALE
GQDNGKPELK AEGAKVTKPS KSIPKIGAPA KAADPKKDED DDSDDESDDD LAGEDESGSS
DEMDDDSNSE EESDGDDEET PAKKVDQGKK RPNESAAKTP ISAKKAKTAT PEKTDGKKSV
HVATPHPSKK GGKTPNSTKG QTPNSAGQLS CASCKKSFTN EAGLQQHKKA KHGGQ
