ID   HDX_CHICK               Reviewed;         695 AA.
AC   Q5ZKW8;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Highly divergent homeobox;
GN   Name=HDX; ORFNames=RCJMB04_8n18;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
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DR   EMBL; AJ719966; CAG31625.1; -; mRNA.
DR   RefSeq; NP_001026291.1; NM_001031120.3.
DR   RefSeq; XP_015133765.1; XM_015278279.1.
DR   AlphaFoldDB; Q5ZKW8; -.
DR   SMR; Q5ZKW8; -.
DR   STRING; 9031.ENSGALP00000011393; -.
DR   PaxDb; Q5ZKW8; -.
DR   Ensembl; ENSGALT00000011407; ENSGALP00000011393; ENSGALG00000007041.
DR   GeneID; 422272; -.
DR   KEGG; gga:422272; -.
DR   CTD; 139324; -.
DR   VEuPathDB; HostDB:geneid_422272; -.
DR   eggNOG; ENOG502QPZG; Eukaryota.
DR   GeneTree; ENSGT00390000008591; -.
DR   HOGENOM; CLU_025064_0_0_1; -.
DR   InParanoid; Q5ZKW8; -.
DR   OMA; ASMAEIH; -.
DR   OrthoDB; 465472at2759; -.
DR   PhylomeDB; Q5ZKW8; -.
DR   TreeFam; TF330998; -.
DR   PRO; PR:Q5ZKW8; -.
DR   Proteomes; UP000000539; Chromosome 4.
DR   Bgee; ENSGALG00000007041; Expressed in spermatid and 13 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 2.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 2.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..695
FT                   /note="Highly divergent homeobox"
FT                   /id="PRO_0000299489"
FT   DNA_BIND        3..63
FT                   /note="Homeobox 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   DNA_BIND        440..503
FT                   /note="Homeobox 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          56..81
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          653..695
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        674..695
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   695 AA;  77251 MW;  5E5EC479BDE6057B CRC64;
     MNLRSVFTVE QQRILQRYYE NGMTNQSKNC FQLILQCAQE TKLDFSVVRT WVGNKRRKMS
     SKSALESGGA PPGTAHTAPS VPPEAMVRNV VNIARSQSQQ SSWTSSNNDV IVTGIYSPAS
     SSNRQGSTKQ TNASMAEIHK TSIPRLPGKS DADFQQQHIP IGRQIPHCKN ASLLVGEKTI
     ILSRQTSVLN SANSIYSHTK KSYGGSSVQT AELVLPQKPM ICHRPCKAEL MGCQRLQKPE
     HAALASHGPP GQRANARDPC STQNLEIREV FSLAVTDQPQ RIVGGSTAQK HCSVEGSSLS
     IAMETGDVDD EYAREEELAS MGAQIQSYSR YYESSSSIRV ENQSAALSGP GRNVSCSSQM
     VNARDVPDSM LYHSRDYHLP ARTSLHTSST LYNSANTSRN TFSPHFTSSN QLRLSQNQNN
     YQISGNLTVP WITGCSRKRA LQDRTQFSDR DLATLKKYWD NGMTSLGSVC REKIEAVAAE
     LNVDCEIVRT WIGNRRRKYR LMGIEVPPPR GGPADFSDQS EFVSKSALNP GEETATEVGD
     DNDRNDEVSI CLSEGSSQEE TNEVLQNEEI HHKDDDRNPV SADNVKIEII DDEESDMISN
     SEVDQMSSLL DYKNEEVRFI ENELENHKQK YFELQTFTRS LILAIKSDDK EQQQALLSDL
     PPELEEMDFN HTSPEPDDTS FSLSSLSEKN ASDSL