HDX_HUMAN
ID HDX_HUMAN Reviewed; 690 AA.
AC Q7Z353; A8K1Y5; B7ZL18; Q5JZB4; Q96NK7;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Highly divergent homeobox;
GN Name=HDX; Synonyms=CXorf43;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP SER-397.
RC TISSUE=Brain, and Hippocampus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Colon endothelium;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT SER-397.
RC TISSUE=Heart, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PROTEIN SEQUENCE OF 164-194; 257-263; 326-347; 614-623 AND 629-634, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Lung carcinoma;
RA Bienvenut W.V., Vousden K.H., Lukashchuk N.;
RL Submitted (MAR-2008) to UniProtKB.
RN [7]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-135; LYS-140; LYS-144; LYS-163;
RP LYS-172; LYS-194; LYS-212; LYS-221; LYS-232 AND LYS-613, AND IDENTIFICATION
RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
RN [8]
RP STRUCTURE BY NMR OF 435-501.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of the homeobox domain of the hypothetical protein,
RT DKFZp686K21156.";
RL Submitted (FEB-2009) to the PDB data bank.
CC -!- INTERACTION:
CC Q7Z353; Q9Y3E2: BOLA1; NbExp=3; IntAct=EBI-1052734, EBI-1049556;
CC Q7Z353; A0A087WZT3: BOLA2B; NbExp=3; IntAct=EBI-1052734, EBI-12006120;
CC Q7Z353; Q2TAC2-2: CCDC57; NbExp=3; IntAct=EBI-1052734, EBI-10961624;
CC Q7Z353; Q9UI47-2: CTNNA3; NbExp=3; IntAct=EBI-1052734, EBI-11962928;
CC Q7Z353; Q5TD97: FHL5; NbExp=3; IntAct=EBI-1052734, EBI-750641;
CC Q7Z353; Q96CN9: GCC1; NbExp=3; IntAct=EBI-1052734, EBI-746252;
CC Q7Z353; P25800: LMO1; NbExp=3; IntAct=EBI-1052734, EBI-8639312;
CC Q7Z353; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-1052734, EBI-739832;
CC Q7Z353; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-1052734, EBI-10172526;
CC Q7Z353; O15160: POLR1C; NbExp=3; IntAct=EBI-1052734, EBI-1055079;
CC Q7Z353; Q8WWV3: RTN4IP1; NbExp=3; IntAct=EBI-1052734, EBI-743502;
CC Q7Z353; Q9UMX1: SUFU; NbExp=4; IntAct=EBI-1052734, EBI-740595;
CC Q7Z353; Q9BZW7: TSGA10; NbExp=3; IntAct=EBI-1052734, EBI-744794;
CC Q7Z353; Q8N0Z6: TTC5; NbExp=3; IntAct=EBI-1052734, EBI-9526213;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q7Z353-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7Z353-2; Sequence=VSP_027708;
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DR EMBL; AK055240; BAB70886.1; -; mRNA.
DR EMBL; BX538112; CAD98024.1; -; mRNA.
DR EMBL; AK290050; BAF82739.1; -; mRNA.
DR EMBL; AL022160; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL035552; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471104; EAW98572.1; -; Genomic_DNA.
DR EMBL; CH471104; EAW98573.1; -; Genomic_DNA.
DR EMBL; BC101720; AAI01721.1; -; mRNA.
DR EMBL; BC101722; AAI01723.1; -; mRNA.
DR EMBL; BC143522; AAI43523.1; -; mRNA.
DR CCDS; CCDS35342.1; -. [Q7Z353-1]
DR CCDS; CCDS55456.1; -. [Q7Z353-2]
DR RefSeq; NP_001170949.1; NM_001177478.1. [Q7Z353-2]
DR RefSeq; NP_001170950.1; NM_001177479.1. [Q7Z353-1]
DR RefSeq; NP_653258.2; NM_144657.4. [Q7Z353-1]
DR RefSeq; XP_006724682.1; XM_006724619.1. [Q7Z353-2]
DR RefSeq; XP_011529165.1; XM_011530863.2. [Q7Z353-1]
DR RefSeq; XP_011529166.1; XM_011530864.1. [Q7Z353-1]
DR RefSeq; XP_016884763.1; XM_017029274.1. [Q7Z353-1]
DR PDB; 2DA4; NMR; -; A=435-501.
DR PDBsum; 2DA4; -.
DR AlphaFoldDB; Q7Z353; -.
DR SMR; Q7Z353; -.
DR BioGRID; 126559; 24.
DR IntAct; Q7Z353; 18.
DR STRING; 9606.ENSP00000297977; -.
DR iPTMnet; Q7Z353; -.
DR PhosphoSitePlus; Q7Z353; -.
DR BioMuta; HDX; -.
DR DMDM; 74762426; -.
DR EPD; Q7Z353; -.
DR MassIVE; Q7Z353; -.
DR PaxDb; Q7Z353; -.
DR PeptideAtlas; Q7Z353; -.
DR PRIDE; Q7Z353; -.
DR ProteomicsDB; 69008; -. [Q7Z353-1]
DR ProteomicsDB; 69009; -. [Q7Z353-2]
DR Antibodypedia; 28380; 57 antibodies from 14 providers.
DR DNASU; 139324; -.
DR Ensembl; ENST00000297977.9; ENSP00000297977.5; ENSG00000165259.14. [Q7Z353-1]
DR Ensembl; ENST00000373177.3; ENSP00000362272.2; ENSG00000165259.14. [Q7Z353-1]
DR Ensembl; ENST00000506585.6; ENSP00000423670.2; ENSG00000165259.14. [Q7Z353-2]
DR GeneID; 139324; -.
DR KEGG; hsa:139324; -.
DR MANE-Select; ENST00000373177.3; ENSP00000362272.2; NM_001177479.2; NP_001170950.1.
DR UCSC; uc004eek.3; human. [Q7Z353-1]
DR CTD; 139324; -.
DR DisGeNET; 139324; -.
DR GeneCards; HDX; -.
DR HGNC; HGNC:26411; HDX.
DR HPA; ENSG00000165259; Low tissue specificity.
DR MIM; 300994; gene.
DR neXtProt; NX_Q7Z353; -.
DR OpenTargets; ENSG00000165259; -.
DR PharmGKB; PA162390630; -.
DR VEuPathDB; HostDB:ENSG00000165259; -.
DR eggNOG; ENOG502QPZG; Eukaryota.
DR GeneTree; ENSGT00390000008591; -.
DR HOGENOM; CLU_025064_0_0_1; -.
DR InParanoid; Q7Z353; -.
DR OMA; ASMAEIH; -.
DR OrthoDB; 465472at2759; -.
DR PhylomeDB; Q7Z353; -.
DR TreeFam; TF330998; -.
DR PathwayCommons; Q7Z353; -.
DR SignaLink; Q7Z353; -.
DR BioGRID-ORCS; 139324; 9 hits in 725 CRISPR screens.
DR ChiTaRS; HDX; human.
DR EvolutionaryTrace; Q7Z353; -.
DR GenomeRNAi; 139324; -.
DR Pharos; Q7Z353; Tbio.
DR PRO; PR:Q7Z353; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q7Z353; protein.
DR Bgee; ENSG00000165259; Expressed in calcaneal tendon and 99 other tissues.
DR ExpressionAtlas; Q7Z353; baseline and differential.
DR Genevisible; Q7Z353; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR SMART; SM00389; HOX; 2.
DR SUPFAM; SSF46689; SSF46689; 2.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Direct protein sequencing; DNA-binding;
KW Homeobox; Isopeptide bond; Nucleus; Reference proteome; Repeat;
KW Ubl conjugation.
FT CHAIN 1..690
FT /note="Highly divergent homeobox"
FT /id="PRO_0000299487"
FT DNA_BIND 3..63
FT /note="Homeobox 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT DNA_BIND 435..498
FT /note="Homeobox 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 55..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 112..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 501..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 664..690
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 670..690
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 135
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 140
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 144
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 163
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 172
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 194
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 212
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 221
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 232
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 613
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 1..58
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_027708"
FT VARIANT 193
FT /note="A -> T (in dbSNP:rs35653454)"
FT /id="VAR_034827"
FT VARIANT 397
FT /note="F -> S (in dbSNP:rs35161124)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_034828"
FT HELIX 444..454
FT /evidence="ECO:0007829|PDB:2DA4"
FT TURN 455..459
FT /evidence="ECO:0007829|PDB:2DA4"
FT HELIX 463..476
FT /evidence="ECO:0007829|PDB:2DA4"
FT HELIX 480..497
FT /evidence="ECO:0007829|PDB:2DA4"
SQ SEQUENCE 690 AA; 77206 MW; 572AA4D182400736 CRC64;
MNLRSVFTVE QQRILQRYYE NGMTNQSKNC FQLILQCAQE TKLDFSVVRT WVGNKRRKMS
SKNSESGTAT TGTSLSAPDI TVRNVVNIAR PSSQQSSWTS ANNDVIVTGI YSPASSSSRQ
GTNKHTDTQI TEAHKIPIQK TATKNDTEFQ LHIPVQRQVA HCKNASLLLG EKTIILSRQT
SVLNAGNSVF NHAKKNYGNS SVQASEMTVP QKPSVCHRPC KIEPVGIQRS YKPEHTGPAL
HNLCGQKPTI RDPYCRTQNL EIREVFSLAV SDYPQRILGG NAPQKPSSAE GNCLSIAMET
GDAEDEYARE EELASMRAQI PSYSRFYESG SSLRAENQST TLPGPGRNMP NSQMVNIRDM
SDNVLYQNRN YHLTPRTSLH TASSTMYSNT NPLRSNFSPH FASSNQLRLS QNQNNYQISG
NLTVPWITGC SRKRALQDRT QFSDRDLATL KKYWDNGMTS LGSVCREKIE AVATELNVDC
EIVRTWIGNR RRKYRLMGIE VPPPRGGPAD FSEQPESGSL SALTPGEEAG PEVGEDNDRN
DEVSICLSEG SSQEEPNEVV PNDARAHKEE DHHAVTTDNV KIEIIDDEES DMISNSEVEQ
VNSFLDYKNE EVKFIENELE IQKQKYFKLQ TFVRSLILAM KADDKEQQQA LLSDLPPELE
EMDFNHASLE PDDTSFSVSS LSEKNVSESL
