HDX_MOUSE
ID HDX_MOUSE Reviewed; 692 AA.
AC Q14B70; Q14B69;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 22-AUG-2006, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Highly divergent homeobox;
GN Name=Hdx;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q14B70-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q14B70-2; Sequence=VSP_027709;
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DR EMBL; BX539333; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC116300; AAI16301.1; -; mRNA.
DR EMBL; BC116301; AAI16302.1; -; mRNA.
DR CCDS; CCDS41105.1; -. [Q14B70-1]
DR CCDS; CCDS72422.1; -. [Q14B70-2]
DR RefSeq; NP_001074018.1; NM_001080549.2. [Q14B70-1]
DR RefSeq; NP_001277388.1; NM_001290459.1. [Q14B70-2]
DR AlphaFoldDB; Q14B70; -.
DR SMR; Q14B70; -.
DR BioGRID; 232805; 2.
DR STRING; 10090.ENSMUSP00000109049; -.
DR iPTMnet; Q14B70; -.
DR PhosphoSitePlus; Q14B70; -.
DR jPOST; Q14B70; -.
DR PaxDb; Q14B70; -.
DR PeptideAtlas; Q14B70; -.
DR PRIDE; Q14B70; -.
DR Antibodypedia; 28380; 57 antibodies from 14 providers.
DR Ensembl; ENSMUST00000038472; ENSMUSP00000043482; ENSMUSG00000034551. [Q14B70-2]
DR Ensembl; ENSMUST00000113422; ENSMUSP00000109049; ENSMUSG00000034551. [Q14B70-1]
DR GeneID; 245596; -.
DR KEGG; mmu:245596; -.
DR UCSC; uc009udb.1; mouse. [Q14B70-1]
DR CTD; 139324; -.
DR MGI; MGI:2685226; Hdx.
DR VEuPathDB; HostDB:ENSMUSG00000034551; -.
DR eggNOG; ENOG502QPZG; Eukaryota.
DR GeneTree; ENSGT00390000008591; -.
DR HOGENOM; CLU_025064_0_0_1; -.
DR InParanoid; Q14B70; -.
DR OMA; ASMAEIH; -.
DR OrthoDB; 465472at2759; -.
DR TreeFam; TF330998; -.
DR BioGRID-ORCS; 245596; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q14B70; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q14B70; protein.
DR Bgee; ENSMUSG00000034551; Expressed in epiblast (generic) and 37 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR SMART; SM00389; HOX; 2.
DR SUPFAM; SSF46689; SSF46689; 2.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Homeobox; Isopeptide bond; Nucleus;
KW Reference proteome; Repeat; Ubl conjugation.
FT CHAIN 1..692
FT /note="Highly divergent homeobox"
FT /id="PRO_0000299488"
FT DNA_BIND 3..63
FT /note="Homeobox 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT DNA_BIND 437..500
FT /note="Homeobox 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 117..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 505..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 647..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 672..692
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 137
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q7Z353"
FT CROSSLNK 142
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q7Z353"
FT CROSSLNK 146
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q7Z353"
FT CROSSLNK 165
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q7Z353"
FT CROSSLNK 174
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q7Z353"
FT CROSSLNK 196
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q7Z353"
FT CROSSLNK 214
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q7Z353"
FT CROSSLNK 223
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q7Z353"
FT CROSSLNK 234
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q7Z353"
FT VAR_SEQ 1..58
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027709"
SQ SEQUENCE 692 AA; 76861 MW; 66D15D3E4B0E69AA CRC64;
MNLRSVFTVE QQRILQRYYE NGMTNQSKNC FQLILQCAQE TKLDFSVVRT WVGNKRRKMS
SKSCESGAAG TVSGTSLAAP DITVRNVVNI ARPSSQQSSW TSANNDVIVT GIYSPVSSSS
KQGTTKHTNT QITEAHKIPI QKAANKNDTE LQLHIPVQRQ VAHCKNASVL LGEKTIILSR
QTSVLNAGNS VYNHTKKSYG SSPVQASEMT VPQKPSVCQR PCKIEPVGIQ RSYKPEHAGL
ASHNLCGQKP TIRDPCCRTQ NLEIREVFSL AVSDYPQRIL GGNSTQKPAS AEGTCLSIAM
ETGDAEDEYA REEELASMGA QITSYSRFYE SGNSLRAENQ STNLPGPGRN LPNSQMVNIR
DLSDNVLYQT RDYHLTPRTS LHTASSTMYS NTNPSRSNFS PHFVSSNQLR LSQNQNNYQI
SGNLSVPWIT GCSRKRALQD RTQFSDRDLA TLKKYWDNGM TSLGSVCREK IEAVAIELNV
DCEIVRTWIG NRRRKYRLMG IEVPPPRGGP ADFSEQPESG SLSALTPGEE AGPEVGEDND
RNDEVSICLS EASSQEESNE LIPNETRAHK DEEHQAVSAD NVKIEIIDDE ESDMISNSEV
EQENSLLDYK NEEVRFIENE LEIQKQKYFK LQSFVRNLIL AMKADDKDQQ QALLSDLPPE
LEEMDCSHAS PDPDDTSLSV SSLSEKNASD SL
