HD_DICDI
ID HD_DICDI Reviewed; 3095 AA.
AC Q76P24; Q55A25;
DT 20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=HD protein homolog;
GN Name=htt; Synonyms=hd; ORFNames=DDB_G0272344;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: May play a role in microtubule-mediated transport or vesicle
CC function. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the huntingtin family. {ECO:0000305}.
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DR EMBL; AAFI02000008; EAL71324.1; -; Genomic_DNA.
DR RefSeq; XP_645159.1; XM_640067.1.
DR STRING; 44689.DDB0238473; -.
DR PaxDb; Q76P24; -.
DR EnsemblProtists; EAL71324; EAL71324; DDB_G0272344.
DR GeneID; 8618330; -.
DR KEGG; ddi:DDB_G0272344; -.
DR dictyBase; DDB_G0272344; htt.
DR eggNOG; ENOG502QR1D; Eukaryota.
DR HOGENOM; CLU_225804_0_0_1; -.
DR InParanoid; Q76P24; -.
DR OMA; FTHSIHY; -.
DR PRO; PR:Q76P24; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IDA:dictyBase.
DR GO; GO:0005634; C:nucleus; IDA:dictyBase.
DR GO; GO:0140582; P:adenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway; IMP:dictyBase.
DR GO; GO:0016339; P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; IMP:dictyBase.
DR GO; GO:0030154; P:cell differentiation; IMP:dictyBase.
DR GO; GO:0006935; P:chemotaxis; IMP:dictyBase.
DR GO; GO:0043327; P:chemotaxis to cAMP; IMP:dictyBase.
DR GO; GO:0072507; P:divalent inorganic cation homeostasis; IMP:dictyBase.
DR GO; GO:0006971; P:hypotonic response; IMP:dictyBase.
DR GO; GO:0061952; P:midbody abscission; IMP:dictyBase.
DR GO; GO:0010628; P:positive regulation of gene expression; IMP:dictyBase.
DR GO; GO:1902463; P:protein localization to cell leading edge; IMP:dictyBase.
DR GO; GO:0060176; P:regulation of aggregation involved in sorocarp development; IMP:dictyBase.
DR GO; GO:0043520; P:regulation of myosin II filament assembly; IMP:dictyBase.
DR GO; GO:0043666; P:regulation of phosphoprotein phosphatase activity; IMP:dictyBase.
DR GO; GO:0031156; P:regulation of sorocarp development; IMP:dictyBase.
DR GO; GO:0051592; P:response to calcium ion; IMP:dictyBase.
DR GO; GO:0035864; P:response to potassium ion; IMP:dictyBase.
DR GO; GO:0031149; P:sorocarp stalk cell differentiation; IMP:dictyBase.
DR GO; GO:0006412; P:translation; IMP:dictyBase.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR028426; Huntingtin_fam.
DR PANTHER; PTHR10170; PTHR10170; 1.
DR SUPFAM; SSF48371; SSF48371; 2.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Reference proteome; Transport.
FT CHAIN 1..3095
FT /note="HD protein homolog"
FT /id="PRO_0000393721"
FT REGION 105..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 536..561
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1312..1371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1509..1547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2005..2037
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2018..2037
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3095 AA; 346847 MW; 107383A464508100 CRC64;
MDLIRGLDIL SASPIDTEDQ NLRKEKIEAC RTISEQICAP SLRNTADFPR FLSIAISLLL
RAHGDKDLNV YSVAEESLNR TIKILVYSYH ERILFELFKV LKGKPHQHNN EKRLSTNLTD
HLSQNSVTPS VPTTPNYQQS PSTQSPSHST SNSSNNLYNN FSSNSNSNSN SNSNSSSNNN
SGNTTPGNNT NNSNGNANSI FNTANQILSK PFPLKSQRIA LIKFGEICSF IRPSKCRKYI
LSLVPPINSL LSIIEDESLQ ESISISMENI SKILIPYLKE NEVHQLIDLF SRNLQQPSAA
VRRAASLSIT SICRYHPRPL FEFTIEFLYN FTFPNSPPIS SITSASCIPA SSNTNTLQNS
KILGVLFSYL QLIKLAEELS SNDIKILDGF SLKIQFFVHF ILKYIQVPID GEPYDHNIVG
LSLELLQQLL VTFGPYEYSW PKPLVREVIA QLRHLCFNQQ SSIRVSLKAV VLNCLAQSVK
FFPKLFNDEF FKHQPSTIDS NTVTSAEDHI CRDYLLNISP SDLNFKLFTP ITQQQQQQQQ
QQQQQQQQQQ QHNLTSSTMS GINSTTGVSN HTFSLEPKEE FLYYLNDSDP LLRGGTALMI
GCLIRGYLET DHITSNQIYP TNIALLEDNL SIPTLLIFLL RALMDSSSIT AKLACTGISE
CLPILSQSKF SDWALVTLRH LLCVSSSTYW LVKLEILETL SMIDYIVIEY LEQNIQQKSN
VMNVVINGPN LSISTSSIKI NENNNNSNNS NNNKNNSETG GAVAIPIQSK VLDFLIEQLS
DNDFRVRNSA GKSLVRVIPK LVFTAPLERH SMKGISSKVR ETFDVQDYEN TVLRKRKIFA
NLSHVIGLLV NQLSNPHPDD KIRGCYGALN LICKTYSFPP DTPEQCRTLS SVLANPMLSF
VGDILPLALD RVGLTWVATD FDVHIDIIEI LGYLSRGAEN VLGTYCHNVL RHIVRIINIA
TNIIQFRPTP PLKEVKSNPS GIHVNSPLLK APTHLGSFTH SIHYIKLYSK LLTARINSIT
IFGIDRFSQL RQACFETLSV MLKCAGKTIL PYTEEIIGYL TTHFEQEPVS VIKCINELFL
VTMKPTPIVS ISSLSQKSRD LNIGGGFIST GGGGGGGSGG INSSSSSLKQ YEPRSIESHS
SSSNSHDEMF LNSRSVFSSL LTFGTPNLKQ HYDFINEVPS SHNINYSYSN SEINRIISNE
DRKLNFKLFE PLIIGSMIEY QTTHSHELKI AILLMLSKLS KFGLDLSLFD KENHFPTYFI
EELKETHCLL SKPNQVLSYS YDLLGSMFIY RKLFPDSSVS IDDIKKLFFQ PPPQQQQQTN
QNKSQSLNST PNISSNNNNN NNNNNNNNNN NNNNNNNNSN SSQSLNNSTV IGNNSSHPYS
YTIPTIIENC HSFVRYLYDP NDKYPDTDFR ERFLSFLLSN LQYSQTIDIL ILIVTIVQPN
STLHQKFSQQ ISHQLFTNLS LGDSPFFIIN SIEEVERLYV LIDKLHSSSL SAARWADALL
SVSPQFVNKS TSSSSSSSST ATSPSSSSSS TTTTTTTSTN TTTTTPSDPL IRKRILLLRE
SILEAYELRW LPPLLVLLRT GCKLPEEARI SAARQSRFLS NHDNKHQPGP SAAIISTLLL
KLIRNAVSVF SLYKPKNVLF TQLINHLLYY SSIFFNKNLV PHISAQSLSN SPNFGATNTT
TGSGSVSPLS SSSSSTITVT TMAMGSSLMK QPSSSLLLSP TVGGSSSTIN LFMDSLKGIL
ALDNGTIIQE ITTSLLSYGG TSTSIHAVKL LLLLGRLPNQ QVIEGADLVW KQYALSNNWQ
SCGCEHFLTH HIIFLLYCQS IVVLKSQNIE LSETFLDKIV LLINESTVKK LIEFLVKGGS
NSDQNQYIEI FTQHLVKIFS RVSNSLDLRK KQKLLRLLSY LPANRETLEL LIVNFLQTDD
ISLQVSGERI LNLNINNLIE TYGPQNSLEI IQELYQIFMS NFVKSTTNQS VQSLFLKLIK
NLSPSSAYQG ITPTHNNVIE KLKEKELTNN NNNNNNNIIE KEEEEKEKEK EKVKEEEEGN
NIEKLIQLQI ETIKKNNQIS DLKTVPWDYF VELIKSRYYS NNLNQHSFNN ISILSQIDKD
ATISLLESKS LDGTLLPAFI SSVYSLEFQD EIQAYLLKKV DTLLGLAGEI GTDPLKGGPP
FLSDSVWDEL RETTRCLSNF INKFGLGELC ESKLLKVSTW AFIESFRRWR AEIINPYDFK
LVLELSRSII LKSTASILTI TDDSEWCSLL LCLYKLYCLV IRPHFGYISG QRELEENFSQ
DPTQISLTQS NEMIKFLVSL LTNVKSYTPM PGSHIGQLIF DSFIRAIIPL STKAFDFIYP
TVSTSSEDEF GGGIIPNCPI FSSNVSPEQN IKALVSFIHF VDIDDEFKFK QIWEMLEPIF
VSPLGDAEMG SDEITEECKC LSLSGMATMI IKVCFEVTGV NSQVNLLETS TIPKSTYNHI
PREKDLMFLN TPTGKKLNHL LSTIYGDMPQ SELPLGGAIE SVSSSSSMFG ESSGNHQNMS
SSSLSAYHFN IERSFSSNQF GSDQISLSDL RLFKTPYFIG VNFTPIIQKL LESFESFLVN
PMCPPMLKKD ILKSTVLLSD LFNREQVIWM FKTFTTIYAQ DEIDDFLLKQ HLILGICKGI
AILQTPPNVG DSNAHSVGIF EMLKSALDHQ NISLQVSALD GILYLLEGKV NKYIQGSLLQ
FLFRWIPTRL SSVPFPPVSL TLRVLATMFL MIEQYSREAE ETLFTKRAVT TCIQLGQQQS
TPVPIVYGVF RGLDRLLVSF SLSHSQRELI SHFSLKSLPS ENPIRSLLAL GLMVTCIYTG
DETGINSPSF TKSSISSIGS GGVNSLTAFE GSFSSSSIES PLNSALDSVM SSFIMDDNYS
GSGGNSLING GGGGDPLSSL DRQKFSRVNN MEKVKMLFDK IRLVSHFSYE SHVLSEVLPV
VIVDLFPSVD QVLSFILGEF LKQSKTNSKL MCQIISKVFD FLVENDTSEN TNQHLINYWI
IICLQNFFQI QNPTHCLWAL TYLFLTSSPK RSFKLLESEF ASKIQTNEKL FIIIASEFYF
NKELSKENKQ LFKDSFSKLK IEPYISLLKV INTTQ
