ID   HE65_NPVAC              Reviewed;         553 AA.
AC   Q08539;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   23-FEB-2022, entry version 54.
DE   RecName: Full=Protein Early 65 kDa;
GN   Name=HE65;
OS   Autographa californica nuclear polyhedrosis virus (AcMNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=46015;
OH   NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=E;
RX   PubMed=8371346; DOI=10.1128/jvi.67.10.5867-5872.1993;
RA   Becker D., Knebel-Moersdorf D.;
RT   "Sequence and temporal appearance of the early transcribed baculovirus gene
RT   HE65.";
RL   J. Virol. 67:5867-5872(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C6;
RX   PubMed=8030224; DOI=10.1006/viro.1994.1380;
RA   Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D.;
RT   "The complete DNA sequence of Autographa californica nuclear polyhedrosis
RT   virus.";
RL   Virology 202:586-605(1994).
RN   [3]
RP   FUNCTION.
RX   PubMed=12414968; DOI=10.1128/jvi.76.23.12281-12289.2002;
RA   Ohkawa T., Rowe A.R., Volkman L.E.;
RT   "Identification of six Autographa californica multicapsid
RT   nucleopolyhedrovirus early genes that mediate nuclear localization of G-
RT   actin.";
RL   J. Virol. 76:12281-12289(2002).
RN   [4]
RP   SUBCELLULAR LOCATION.
RX   PubMed=22592260; DOI=10.1099/vir.0.041848-0;
RA   Gandhi K.M., Ohkawa T., Welch M.D., Volkman L.E.;
RT   "Nuclear localization of actin requires AC102 in Autographa californica
RT   multiple nucleopolyhedrovirus-infected cells.";
RL   J. Gen. Virol. 93:1795-1803(2012).
CC   -!- FUNCTION: May participate in the recruitment of G-actin to the host
CC       nucleus. {ECO:0000269|PubMed:12414968}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000269|PubMed:22592260}.
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DR   EMBL; X73577; CAA51979.1; -; mRNA.
DR   EMBL; L22858; AAA66735.1; -; Genomic_DNA.
DR   PIR; B72863; B72863.
DR   RefSeq; NP_054135.1; NC_001623.1.
DR   PRIDE; Q08539; -.
DR   GeneID; 1403938; -.
DR   KEGG; vg:1403938; -.
DR   Proteomes; UP000008292; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR021122; RNA_ligase_dom_REL/Rnl2.
DR   Pfam; PF09414; RNA_ligase; 1.
PE   2: Evidence at transcript level;
KW   Early protein; Host cytoplasm; Reference proteome.
FT   CHAIN           1..553
FT                   /note="Protein Early 65 kDa"
FT                   /id="PRO_0000132874"
SQ   SEQUENCE   553 AA;  65577 MW;  4525FDD1032CC1E5 CRC64;
     MVYICIDTGS HAKGYAVESS DTDYHIYTKC DRETFEKFID NKELLKNRHA KDESGNDVKY
     VDLYTGLIGI LTGKSPELSM FSKREDFKDK YGIENLQLYE FVTKLMTVSM VKIIYTLMRY
     KILNNAKGLL QLMFNYVYVE YYLDYKRAPK STKILNMLFN VGDEIKITMD KNNQLVVNDL
     NVLDLNKNNG GYKIDETLTL FVKNVKLLKL YVKLMQRGEY QQEWTEYFQQ WKQQLQDRLH
     HVPEPPERTD IRHNIVMYAL NERGPVMPED ENKIVYQIYP SVSHLDQGKK GTLADKEIIV
     QEKLDGCNFR IICNQNKITY GSRNTYRPDG NFMNYYRIRK DLETCMRSLQ ARFNDGFIVY
     GELMGWKDDA KTTPINVINY VDQKESLKYY AYEIQLYGGE FVPFVEAQEL LTNVGFNTIP
     CHKYLYNDFV ERLNFKSLMF PQSPLEGFII RCGNLIYKLK SDYKDLNKLK IEKGPFEWLT
     CDYIKSNCDA IDKSDMMKIL IFCYNMCKVK NYNEKLLFNK VFNLFRQQFN LNHNDYKNLY
     KQYVNMCKCT EYK