HEAT1_CAEEL
ID HEAT1_CAEEL Reviewed; 1650 AA.
AC Q23495;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=HEAT repeat-containing protein 1 homolog;
DE AltName: Full=Target of erk kinase protein 1;
GN Name=toe-1; ORFNames=ZK430.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC Involved in ribosome biosynthesis (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the HEATR1/UTP10 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FO080155; CCD61670.1; -; Genomic_DNA.
DR PIR; T27864; T27864.
DR RefSeq; NP_494782.1; NM_062381.4.
DR AlphaFoldDB; Q23495; -.
DR SMR; Q23495; -.
DR BioGRID; 39135; 3.
DR STRING; 6239.ZK430.1; -.
DR iPTMnet; Q23495; -.
DR EPD; Q23495; -.
DR PaxDb; Q23495; -.
DR PeptideAtlas; Q23495; -.
DR PRIDE; Q23495; -.
DR EnsemblMetazoa; ZK430.1.1; ZK430.1.1; WBGene00022739.
DR GeneID; 173779; -.
DR KEGG; cel:CELE_ZK430.1; -.
DR UCSC; ZK430.1; c. elegans.
DR CTD; 173779; -.
DR WormBase; ZK430.1; CE05078; WBGene00022739; toe-1.
DR eggNOG; KOG1837; Eukaryota.
DR GeneTree; ENSGT00390000015845; -.
DR HOGENOM; CLU_242403_0_0_1; -.
DR InParanoid; Q23495; -.
DR OMA; CARWQRS; -.
DR OrthoDB; 524830at2759; -.
DR PhylomeDB; Q23495; -.
DR Reactome; R-CEL-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR PRO; PR:Q23495; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00022739; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0030686; C:90S preribosome; IBA:GO_Central.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0034455; C:t-UTP complex; IBA:GO_Central.
DR GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR012954; BP28_C_dom.
DR InterPro; IPR022125; U3snoRNP10_N.
DR InterPro; IPR040191; UTP10.
DR PANTHER; PTHR13457; PTHR13457; 2.
DR Pfam; PF08146; BP28CT; 1.
DR Pfam; PF12397; U3snoRNP10; 1.
DR SMART; SM01036; BP28CT; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW rRNA processing.
FT CHAIN 1..1650
FT /note="HEAT repeat-containing protein 1 homolog"
FT /id="PRO_0000186203"
FT REPEAT 1609..1645
FT /note="HEAT"
FT REGION 1183..1210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1650 AA; 185228 MW; A414B7C8F739F029 CRC64;
MATSLTSQLE NLRTSAARHL TVEKRHVSLL FDRKEANKLS NETAHRIGVA GLEQMKRIDP
VFDTEFANDL FSEERVDFVR SMLEKGANEE LNKQIEKLLL ELSPYLQHFA CQQVLEFLIH
TYQIYSFNAE TLLLTFLPFH ETKVYSRLLR ILDFDWKRSK EWQFMQQFTK TETPIPFTSI
ARATLSSKHS IITCITDHIR HAVEIVGSDY LEIKHPILFN FHAKLLLSMF TDPEKVDEMM
LAKLMPFIEN GIKSPMKSFR YSAMVVISQL VLTVKLKDEV LNSMCKLLIT KMRSDTAAAS
LSTLMVVFQQ QNVQSLSKNT LKKLLRHEEG IDVWKILKEL SERTDTTKFF NVLWKELIVL
SKDAESEDNT LAIDVLIETI EDASILTGDQ AGTILKLILQ EGMDGNIFDN KKKLKSNIRA
IGMRFAKQFD AIHAELKAKD KKTLKNVLKE YQIEDIVQFA SEAVAATQSE ESIEIISEEA
PSSKKIKLTA SEKAQKLAQS SEFAKREVFS GDPINKATEW LNGEKWDKVE WALNEMAQRG
EKYFSRKVED DVEQFVLEIV KVVGVGGVKQ IDGGSVKAAL AGANLNPQFV ADLLTKFDGV
SEIAPKRTKG AQKKNLVEKT FGTEESWEAF NQRVVFVLDL LNARQIIPSS EKVLAALFAV
VKQVNSKSDV ESSSYQQHLA VNAIRKILEH PEKTKIGASE VDMDCVIETM RSTHNHHLLR
DCLRLIVAAA KHTPNSVVKH VMSVFTFMGN GMLRKDNELT LSIVEKTVES LFSTIINSSG
QAVLTKQQQT EKLIELARLF AASAIDIPAH RRARIAQAIA RAVQAENAST VVLVLVSSFC
ARWQRSSDAA AQEAMKRGSD QDAYDDLAIE LLSALNPFEQ LSSVLEMCEY VRRLGGDKPA
KSTTTKKDLD TMIFDRTAQT LPRIRHFRYV VVTLISRIFS NRVLIERLAA YDDEELLKNA
LPLGKRLIEC SVELDEFANK EANDQDGSDP QAQRYWVAFA SRTEVVSEKL RHLLPGGVAA
RLIADVLQEC VNDKKMSYKM CEKVLQLANI KLGHDRYLFA DSGINEKELI TLAQALNKFI
VAETKSEEKM RMCQNSAYTL KLIAKNLPSQ SESLVLADTM QRCVSIVSQY QKLDENLTGN
VLLLAGELIR SHNMRSTIHH ATSLLKTCLA TVQECIARFS KPQYDSAASP GSSVAGGRGN
RGHRIRQQSL GGNKFGSDTL LICSLTCIQR VYDQFASFVV ESTGDVIIRY CRLIARFGDP
SELLALNQPS SSTTAAFQGG SQTSGFGSKT GIHHRLSLIR RSLLSIELRV LPAHIVKTVG
ELKTEKKALS ALFNLLTGYI ETQHQQKPEI LRKSVIQLRR TFVSDVITPT LIVRSQERQS
DQFENVEKLE HTVFNFVISI ASILSEVEFR TVVNELVAWA EPGLEAKADL AARLRLVSLL
HFANDLYTSF NSLALPYFGR ILEISALVLK KCNATLLLGT DELLLSGKRG SIEALETDLA
LTLAIDVISN AARHRDFFTV DRCQLVSDVI VNELVNTKVE GHEKRCSDHL VPAIYRIGNA
DPDSFPELLN KIMLKTRDSR AKIRYRALIV LELLIKEIGD GVQPHLSILL PFLNELIEDE
NKQVEAQCQK VINSLQHKFG ETFWSGGSSA