ID   HEAT1_CAEEL             Reviewed;        1650 AA.
AC   Q23495;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=HEAT repeat-containing protein 1 homolog;
DE   AltName: Full=Target of erk kinase protein 1;
GN   Name=toe-1; ORFNames=ZK430.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC       Involved in ribosome biosynthesis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HEATR1/UTP10 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FO080155; CCD61670.1; -; Genomic_DNA.
DR   PIR; T27864; T27864.
DR   RefSeq; NP_494782.1; NM_062381.4.
DR   AlphaFoldDB; Q23495; -.
DR   SMR; Q23495; -.
DR   BioGRID; 39135; 3.
DR   STRING; 6239.ZK430.1; -.
DR   iPTMnet; Q23495; -.
DR   EPD; Q23495; -.
DR   PaxDb; Q23495; -.
DR   PeptideAtlas; Q23495; -.
DR   PRIDE; Q23495; -.
DR   EnsemblMetazoa; ZK430.1.1; ZK430.1.1; WBGene00022739.
DR   GeneID; 173779; -.
DR   KEGG; cel:CELE_ZK430.1; -.
DR   UCSC; ZK430.1; c. elegans.
DR   CTD; 173779; -.
DR   WormBase; ZK430.1; CE05078; WBGene00022739; toe-1.
DR   eggNOG; KOG1837; Eukaryota.
DR   GeneTree; ENSGT00390000015845; -.
DR   HOGENOM; CLU_242403_0_0_1; -.
DR   InParanoid; Q23495; -.
DR   OMA; CARWQRS; -.
DR   OrthoDB; 524830at2759; -.
DR   PhylomeDB; Q23495; -.
DR   Reactome; R-CEL-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:Q23495; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00022739; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0030686; C:90S preribosome; IBA:GO_Central.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0034455; C:t-UTP complex; IBA:GO_Central.
DR   GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR012954; BP28_C_dom.
DR   InterPro; IPR022125; U3snoRNP10_N.
DR   InterPro; IPR040191; UTP10.
DR   PANTHER; PTHR13457; PTHR13457; 2.
DR   Pfam; PF08146; BP28CT; 1.
DR   Pfam; PF12397; U3snoRNP10; 1.
DR   SMART; SM01036; BP28CT; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..1650
FT                   /note="HEAT repeat-containing protein 1 homolog"
FT                   /id="PRO_0000186203"
FT   REPEAT          1609..1645
FT                   /note="HEAT"
FT   REGION          1183..1210
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1650 AA;  185228 MW;  A414B7C8F739F029 CRC64;
     MATSLTSQLE NLRTSAARHL TVEKRHVSLL FDRKEANKLS NETAHRIGVA GLEQMKRIDP
     VFDTEFANDL FSEERVDFVR SMLEKGANEE LNKQIEKLLL ELSPYLQHFA CQQVLEFLIH
     TYQIYSFNAE TLLLTFLPFH ETKVYSRLLR ILDFDWKRSK EWQFMQQFTK TETPIPFTSI
     ARATLSSKHS IITCITDHIR HAVEIVGSDY LEIKHPILFN FHAKLLLSMF TDPEKVDEMM
     LAKLMPFIEN GIKSPMKSFR YSAMVVISQL VLTVKLKDEV LNSMCKLLIT KMRSDTAAAS
     LSTLMVVFQQ QNVQSLSKNT LKKLLRHEEG IDVWKILKEL SERTDTTKFF NVLWKELIVL
     SKDAESEDNT LAIDVLIETI EDASILTGDQ AGTILKLILQ EGMDGNIFDN KKKLKSNIRA
     IGMRFAKQFD AIHAELKAKD KKTLKNVLKE YQIEDIVQFA SEAVAATQSE ESIEIISEEA
     PSSKKIKLTA SEKAQKLAQS SEFAKREVFS GDPINKATEW LNGEKWDKVE WALNEMAQRG
     EKYFSRKVED DVEQFVLEIV KVVGVGGVKQ IDGGSVKAAL AGANLNPQFV ADLLTKFDGV
     SEIAPKRTKG AQKKNLVEKT FGTEESWEAF NQRVVFVLDL LNARQIIPSS EKVLAALFAV
     VKQVNSKSDV ESSSYQQHLA VNAIRKILEH PEKTKIGASE VDMDCVIETM RSTHNHHLLR
     DCLRLIVAAA KHTPNSVVKH VMSVFTFMGN GMLRKDNELT LSIVEKTVES LFSTIINSSG
     QAVLTKQQQT EKLIELARLF AASAIDIPAH RRARIAQAIA RAVQAENAST VVLVLVSSFC
     ARWQRSSDAA AQEAMKRGSD QDAYDDLAIE LLSALNPFEQ LSSVLEMCEY VRRLGGDKPA
     KSTTTKKDLD TMIFDRTAQT LPRIRHFRYV VVTLISRIFS NRVLIERLAA YDDEELLKNA
     LPLGKRLIEC SVELDEFANK EANDQDGSDP QAQRYWVAFA SRTEVVSEKL RHLLPGGVAA
     RLIADVLQEC VNDKKMSYKM CEKVLQLANI KLGHDRYLFA DSGINEKELI TLAQALNKFI
     VAETKSEEKM RMCQNSAYTL KLIAKNLPSQ SESLVLADTM QRCVSIVSQY QKLDENLTGN
     VLLLAGELIR SHNMRSTIHH ATSLLKTCLA TVQECIARFS KPQYDSAASP GSSVAGGRGN
     RGHRIRQQSL GGNKFGSDTL LICSLTCIQR VYDQFASFVV ESTGDVIIRY CRLIARFGDP
     SELLALNQPS SSTTAAFQGG SQTSGFGSKT GIHHRLSLIR RSLLSIELRV LPAHIVKTVG
     ELKTEKKALS ALFNLLTGYI ETQHQQKPEI LRKSVIQLRR TFVSDVITPT LIVRSQERQS
     DQFENVEKLE HTVFNFVISI ASILSEVEFR TVVNELVAWA EPGLEAKADL AARLRLVSLL
     HFANDLYTSF NSLALPYFGR ILEISALVLK KCNATLLLGT DELLLSGKRG SIEALETDLA
     LTLAIDVISN AARHRDFFTV DRCQLVSDVI VNELVNTKVE GHEKRCSDHL VPAIYRIGNA
     DPDSFPELLN KIMLKTRDSR AKIRYRALIV LELLIKEIGD GVQPHLSILL PFLNELIEDE
     NKQVEAQCQK VINSLQHKFG ETFWSGGSSA