ID   HEAT1_DANRE             Reviewed;        2159 AA.
AC   Q7SY48;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=HEAT repeat-containing protein 1;
DE   AltName: Full=Protein BAP28;
GN   Name=heatr1; ORFNames=zgc:63510;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=16531401; DOI=10.1074/jbc.m601892200;
RA   Azuma M., Toyama R., Laver E., Dawid I.B.;
RT   "Perturbation of rRNA synthesis in the bap28 mutation leads to apoptosis
RT   mediated by p53 in the zebrafish central nervous system.";
RL   J. Biol. Chem. 281:13309-13316(2006).
CC   -!- FUNCTION: Ribosome biogenesis factor. Involved in nucleolar processing
CC       of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA
CC       transcription by RNA polymerase I. Required for cell survival in the
CC       CNS through its role in rRNA synthesis and processing.
CC       {ECO:0000250|UniProtKB:Q9H583, ECO:0000269|PubMed:16531401}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9H583}.
CC   -!- DISRUPTION PHENOTYPE: Abnormalities in the brain starting at
CC       midsomitogenesis stages. {ECO:0000269|PubMed:16531401}.
CC   -!- SIMILARITY: Belongs to the HEATR1/UTP10 family. {ECO:0000305}.
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DR   EMBL; BC055128; AAH55128.1; -; mRNA.
DR   RefSeq; NP_956194.1; NM_199900.1.
DR   AlphaFoldDB; Q7SY48; -.
DR   SMR; Q7SY48; -.
DR   STRING; 7955.ENSDARP00000066445; -.
DR   PaxDb; Q7SY48; -.
DR   PRIDE; Q7SY48; -.
DR   GeneID; 334446; -.
DR   KEGG; dre:334446; -.
DR   CTD; 55127; -.
DR   ZFIN; ZDB-GENE-030131-6378; heatr1.
DR   eggNOG; KOG1837; Eukaryota.
DR   InParanoid; Q7SY48; -.
DR   OrthoDB; 524830at2759; -.
DR   PhylomeDB; Q7SY48; -.
DR   Reactome; R-DRE-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:Q7SY48; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0030686; C:90S preribosome; IBA:GO_Central.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0034455; C:t-UTP complex; IBA:GO_Central.
DR   GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:ZFIN.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IMP:ZFIN.
DR   GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; IBA:GO_Central.
DR   GO; GO:0043487; P:regulation of RNA stability; IMP:ZFIN.
DR   Gene3D; 1.25.10.10; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR012954; BP28_C_dom.
DR   InterPro; IPR022125; U3snoRNP10_N.
DR   InterPro; IPR040191; UTP10.
DR   PANTHER; PTHR13457; PTHR13457; 1.
DR   Pfam; PF08146; BP28CT; 1.
DR   Pfam; PF12397; U3snoRNP10; 1.
DR   SMART; SM01036; BP28CT; 1.
DR   SUPFAM; SSF48371; SSF48371; 3.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW   Ribosome biogenesis; rRNA processing; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..2159
FT                   /note="HEAT repeat-containing protein 1"
FT                   /id="PRO_0000330921"
FT   REPEAT          346..384
FT                   /note="HEAT 1"
FT   REPEAT          509..548
FT                   /note="HEAT 2"
FT   REPEAT          909..947
FT                   /note="HEAT 3"
FT   REPEAT          1024..1062
FT                   /note="HEAT 4"
FT   REPEAT          1219..1260
FT                   /note="HEAT 5"
FT   REPEAT          1594..1632
FT                   /note="HEAT 6"
FT   REPEAT          1733..1773
FT                   /note="HEAT 7"
FT   REPEAT          2115..2153
FT                   /note="HEAT 8"
SQ   SEQUENCE   2159 AA;  242050 MW;  F00DBBA1D597E70B CRC64;
     MTSLAHQLKR LALPQNDSSL LGRKEVVSVL FDPKDAASMD RSTFHALGCT GLEELMGIDA
     AFSEFQETLF SQGSLTLERS VQSKEVNKKL DKSISLFLTR LSPYFLLKPA LKCIEWLLHR
     FHIHLYNQDS LIACVLPYHE TKVFVRVIQL FKIEDPTHKW HWLHGIQKPG VPLARGTLLT
     HCYKDLGFMD FVCSMVTNSV KAYSELTRDG NCPQLRVIFS FYASTIVSAL DAVEKITNSI
     IAKLLPFVQL GLKSNLSDYT AATYMIVCQM AVKVVMEAQL VDSLSVQLSR SLGRTPQLIR
     EGLSCIIILL QNQKKGVIGQ KTYGYLCAVP TLVSTLQSIS TVHDISPLLS YLLPHLIHSV
     MTQNDEQQNE GLSDSTGLLQ SVFQNLQLSS NLENTAAKLL LEEYVVCGNE LPSDGISALN
     QRIQPTVRLF ESRYPCALDM ALENHVKNVS SDNEKNLLHQ FISLTLSCGK YQILPESETS
     LMLSLNHPLP SVRNMAVDYL KEILNSEHNS FDEAFLKDAL LERIKDDSPE VVLSALKALQ
     HHMGLMDVED TVSSLISLLH RIKPSADWCP VLKEAVRVLD DPRIIEGNPD LKAYISWELL
     PFLVMTRAAP ECVELQMTSA ITETTLISQH PLTQGWAKVL KAVLAKTSES DLLGVANEML
     TTTLIKNLAN MDHATKRNTL ENVCDILSRQ GSSVRDRAAF VVFSSALLQS LQSMTESQHL
     HTAQSVYKLL EPLLLQAYTI QPEQVSDQPA DECLPVCVAL GEFLQKISCG LSAEQEQGLL
     LLSLLRLFIT TLKCPDSTFK GEPWWNPEKM ETTTCCYLRL LCRLFDVVIS GASQGPLAPC
     FRSLMQPLLQ VHLNEPMVLF KFLSLSWGYN SNLGDQLDCR VSAILQTQAL YVGKAFLSSQ
     PVKTLNLLAS DSSPVVPSLL VCVCSGVCEV RRAAIAVLQC LSGLVSSPYH PLVEKLLKSS
     EEIIADSSYL TQALSKFYEE AVSRKDKNKK LASVEQLLQC LQSPFCPSYT SKTLLRALQD
     VHGEPVLSVL LPAVERLLEQ CAPDSCTFLP DEALLLQLLL SKFSEMSAPL LVKDPRCLEV
     FIRALHTSAR PYPTIPSFQI TALEQITKPF FTAIGDEKIQ QKILSILFDL LVGNKSPACA
     QSINSVFKTI AVDCELVANE LIPADKQRVT ATVQQTRRSK MRKTQDTSGA VPEESVVSWP
     RVTLILELLQ HKKKLKRAQY LVPALFNLLS RCLEPAAAEQ ENIEYTKQLI LICLLNVCQK
     LSPEGGPISK DVLEEDKFNM ELVVQCVRVS EMPQTHHHAL LLLGALAGIF PEKVLHNIMP
     IFTFMGANIM RLDDTYSFQV INKTVQAVIP ALIKAHEGGS SQSEGHMETV VAQIIHVFVD
     ALPHVPEHRR LPILSQLMST LGPSRFLWVL MLLLFKQHVT QTSAGATGAE KEAVVERDQD
     FWILVCCEFE VKEQLTSLIK ILQYLMTLPQ DREEAPEKKK PRGRSAVKKD ETVSDLIFSV
     ETHSGKDLRH FKFISISFMA QLLASDGFVG KVADCEDITE STLQALQQDL LVEVLRYIQA
     VARCVEDNAD KPTAKFWRAL LSKSYDTLDK VNALLPMDTF ITVMRGLVGN QLASVRRKAM
     ELLNNKLQQR TKWLKEQITA LLELIGTLLS IVGRSHRQVT AQEEEELAIN RQTALYSLKL
     LCRNFGSDHK EEFVPVLNKA VELVADKDEE KNVMGSALLC VAEVTSTLKA LAIPQLHRLM
     PAVLDTLKER KDLLNNEIYL LSAVTALQRA SETLPHFISP YLLDTILQVT RLTLLARRLT
     SCPQLSVRLA SLSSTLATKL PPRVLIPTIT KCYCSMVDAQ QNRLSPLMNI LKEHISHMDK
     DQLNNHQSEL TSFFLSALDF RAQHCQGDLK KTAEIEGCVI DCLLVMIMKL SEVTFRPLFF
     KLFDWSKIDG ASKDRLLTFY RLADRIADKL KGLFVLFAGQ LVKPFSDLLH QLNISHTDKA
     FFDSEDESDD DSDEEADDNV TKSSLLLQYV LDCLHKIFLY DTQHFLSKER ADALLCPLVD
     QLENMLGGEE TYKSRITTHL VPCIAQFAVA MRDDSQWKVL NYQILLKTRH SSPKVRFSAL
     VMLLELAGKL RENYMVLLPE TIPFLAELME DECEEVEHQV QKVIQEMETI LGEPLQSYF