HEAT1_DICDI
ID HEAT1_DICDI Reviewed; 2237 AA.
AC Q54ML4;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=HEAT repeat-containing protein 1 homolog;
GN Name=heatr1; ORFNames=DDB_G0285875;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Ribosome biogenesis factor. Involved in nucleolar processing
CC of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA
CC transcription by RNA polymerase I. {ECO:0000250|UniProtKB:Q7SY48,
CC ECO:0000250|UniProtKB:Q9H583}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:Q9H583}.
CC -!- SIMILARITY: Belongs to the HEATR1/UTP10 family. {ECO:0000305}.
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DR EMBL; AAFI02000082; EAL64472.1; -; Genomic_DNA.
DR RefSeq; XP_637976.1; XM_632884.1.
DR AlphaFoldDB; Q54ML4; -.
DR SMR; Q54ML4; -.
DR STRING; 44689.DDB0237545; -.
DR PaxDb; Q54ML4; -.
DR PRIDE; Q54ML4; -.
DR EnsemblProtists; EAL64472; EAL64472; DDB_G0285875.
DR GeneID; 8625328; -.
DR KEGG; ddi:DDB_G0285875; -.
DR dictyBase; DDB_G0285875; -.
DR eggNOG; KOG1837; Eukaryota.
DR HOGENOM; CLU_001128_3_0_1; -.
DR InParanoid; Q54ML4; -.
DR OMA; YLLLMQS; -.
DR PhylomeDB; Q54ML4; -.
DR Reactome; R-DDI-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR PRO; PR:Q54ML4; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0030686; C:90S preribosome; IBA:GO_Central.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0034455; C:t-UTP complex; IBA:GO_Central.
DR GO; GO:0030515; F:snoRNA binding; ISS:dictyBase.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; ISS:dictyBase.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR012954; BP28_C_dom.
DR InterPro; IPR022125; U3snoRNP10_N.
DR InterPro; IPR040191; UTP10.
DR PANTHER; PTHR13457; PTHR13457; 1.
DR Pfam; PF08146; BP28CT; 1.
DR Pfam; PF12397; U3snoRNP10; 1.
DR SMART; SM01036; BP28CT; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW Ribosome biogenesis; rRNA processing; Transcription;
KW Transcription regulation.
FT CHAIN 1..2237
FT /note="HEAT repeat-containing protein 1 homolog"
FT /id="PRO_0000330922"
FT REPEAT 224..262
FT /note="HEAT 1"
FT REPEAT 858..895
FT /note="HEAT 2"
FT REPEAT 1586..1624
FT /note="HEAT 3"
FT REPEAT 1674..1712
FT /note="HEAT 4"
FT REPEAT 1715..1761
FT /note="HEAT 5"
FT REPEAT 1767..1805
FT /note="HEAT 6"
FT REPEAT 2104..2142
FT /note="HEAT 7"
FT REPEAT 2191..2229
FT /note="HEAT 8"
FT REGION 962..981
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1920..1960
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2031..2073
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2237 AA; 254183 MW; 7B110BFB11709984 CRC64;
MTTSLDKQLL QVKEKIHYVD VSKKRDSLLF GAVEAANIDL DSVLAMGQEG LSELINIDSR
FKCFQLTLFS DNSKSFNRVL ENKEENNKID IEINKFLELQ SNYFLLSSAH KSLEWLIRRY
RINEFNIDSI ISSIIPYHES NIFAKFLSIL RFEFNKKWQF LTGVQENKVY IPREYFIGVV
GSHPFFLEFI YSTIENYDKK DVMSKPLISF FTAFLIELLS ANTTSYIRDT LSCLTKCLKS
KNSDLQLSSY MILSIIASKV TLSKDVIELL FKTTLKHCTN NFSQAFTFLM VLFQKQKFDS
LPNETLKTLV SIPALFEILL DFNSQEKSLD RVLLILFKYL SKSCIESAES YTLLSQLIEE
LVPISNQYHV LIFNTLTKSY LATTKNSSKD EVDESVINIL RSLNSEVVQD EFKKLSNNNN
NNNNNNNNKQ KLNEIIKLQK SVLQQKTITT SSSNTIFLKL QSNIPSERKE GLTLFKKEYC
SKTGKEKEET TTSTDFNSIS KSFSSTIYQR LIDSDGSIVK EAWNLPSLNL IVSPKELLKA
SIEFFKVQSF LNDKKLLDTV LSTITSVVVN QSSNSSLTPD FVSILLPQLL DISTTTTTTA
TSIIKKLNKD IHPIFNNITS SNIESLIKSI STNLDKESNI TFINQISKST FSTFKSDIFI
ILILLNSIIS CNNNNNNKKN NNNLIYQMFN IIVEISKSYL SKEESIITNI NNLQEVYKII
NENNNNNFNL KQQISLICSL LSIAIDSLFT ISPEQFMKQL QNSSLSSSSN TIEEKMIKEI
QNICKLIFNS KITNIDLVLR SIVKKFFGNQ LVFFKFLSQF WEVNENSENQ DITTIYQSLC
LSGILVNSKS FNRYLINNNQ AVALIPYLLL LKNQDSSIRS TSLDSIQEIY KQIKSSSIEA
SSSTTTSNRL NFYTSNQPTI ELKVLIKFLA QLVQYKNEIT MDKTFLDSYF SKVLFNSQIS
SSSKASSSSD DDDDDDDDVD QDVSKMTKQD IELIGKFLIS SSLLIESLSS RLTMLQSLQS
IKDDVTFVEV TINYISQLLE NVKNATLTYD ESLILDILLK RLGQTSVLTN PKTKKQSLSL
FISSLSISNE LDLTIAGGGN DKPIKYTPLV ALIGSINKSL LLTVPVKEQI GIVETVLSYF
FSESNQIKQL AKNTLLSVLV DATVILPMLL PEKQPQQQQQ STTSLPIPRY NSLFELIRLN
SSKINGISIL VTPILSIIKK METSIVENVE KDALEYCKQL AMASLGSIID CSSVKDVKSL
ETSFDISIII KCVESSNNLQ TCSSALILLS NMASKFPQKL FKFMESIIKM IKFVLTNGDD
NFSFMILERF LIQLLPSLVK QGISLVQIFK LFLDSFSSIP KKFRLQLFNC ICQSVAYKQL
HILFSLILTK KIQDLRIITN KLKHLDKDTI MSSDEQIKEE IDYEQFNEFI SQFSDQIPVL
EMSTSLGSLC QSINLISIES GNCVEALSEE EEEICSLLSR NNSKDNRLLQ ANTLDFICER
LSSKLYLDSF SFDLTSQQKE LVETKYLGAF ENLLILLKKT TEYSEKTSNI KLNGSANSIS
IASGKDKFIK KLLSSINLCM DRYGQLLSVK GFISTITQLL NHSDSNVRRR SLVIFNEKIT
LVKDDLTQDQ VNQFLSLIDS FTRIIDSQNE TETNKQTSLL SFEILARNFS TTNATAFLSQ
IPIIIKSMGH SSHQVVSSSL ICIATLCCEL QAKTIPYIPQ FFPVLLNTLT GSYKTNVEEE
NETRTLLQIS CISSLEMMLN TISKFLSPYL PQLLNALLHP RLTSNSMLSG KLFAQVKRLL
NILTKNVEFR LLLPAMFSAY EFAVQSENDL SLICLFDFVG DISANLGPKD IALHHKSIFK
FYLQCFEFRK KYKNRVKNAD KVEDHIISSF MTLVMKLNEN LFKPLFIKVL DWALNIQNGQ
QNGKHTDDDD EENGSDDEES DEDKPKKKKL VNGKSKSTKT QPEISKDNLL FFYKIVNSLA
SNLKTIFVPY FGYFFDDSIR QLQNIYSNIP FSQQPQQQPQ QPTVNDNTTI TLLNNNNNNN
NNNINNKRKK NQNITNTTTT NNNSNNNLNN SNNNNIDQDE SILCFVISAL EKCFMYDTDG
FLDKQKFEQI LPALVNQLDN QMGTVESYKL RVSRYIAPTI TQLAVVINQD LLWKHLNHTV
LMKTRSPYSI VRYSSMVVVQ SLHKKMGEQL LILLPETIPF ISELLEDSVP EVEQITQDVV
KIIETHLGAE ESISSYL
