HEAT1_DROME
ID HEAT1_DROME Reviewed; 2096 AA.
AC Q9VM75; Q6AWS0; Q8T9E7;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=HEAT repeat-containing protein 1 homolog;
GN Name=l(2)k09022; ORFNames=CG10805;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.;
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 381-2096.
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC Involved in ribosome biosynthesis (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the HEATR1/UTP10 family. {ECO:0000305}.
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DR EMBL; AE014134; AAF52447.2; -; Genomic_DNA.
DR EMBL; BT015178; AAT94407.1; -; mRNA.
DR EMBL; AY069800; AAL39945.1; -; mRNA.
DR RefSeq; NP_609079.2; NM_135235.3.
DR AlphaFoldDB; Q9VM75; -.
DR SMR; Q9VM75; -.
DR BioGRID; 60111; 6.
DR DIP; DIP-18874N; -.
DR IntAct; Q9VM75; 8.
DR STRING; 7227.FBpp0078971; -.
DR PaxDb; Q9VM75; -.
DR PRIDE; Q9VM75; -.
DR EnsemblMetazoa; FBtr0079343; FBpp0078971; FBgn0086451.
DR GeneID; 33960; -.
DR KEGG; dme:Dmel_CG10805; -.
DR FlyBase; FBgn0086451; l(2)k09022.
DR VEuPathDB; VectorBase:FBgn0086451; -.
DR eggNOG; KOG1837; Eukaryota.
DR GeneTree; ENSGT00390000015845; -.
DR HOGENOM; CLU_001128_3_0_1; -.
DR InParanoid; Q9VM75; -.
DR OMA; NDVMWKQ; -.
DR OrthoDB; 524830at2759; -.
DR PhylomeDB; Q9VM75; -.
DR Reactome; R-DME-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR SignaLink; Q9VM75; -.
DR BioGRID-ORCS; 33960; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 33960; -.
DR PRO; PR:Q9VM75; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0086451; Expressed in egg chamber and 24 other tissues.
DR Genevisible; Q9VM75; DM.
DR GO; GO:0030686; C:90S preribosome; IBA:GO_Central.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0034455; C:t-UTP complex; IBA:GO_Central.
DR GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR012954; BP28_C_dom.
DR InterPro; IPR022125; U3snoRNP10_N.
DR InterPro; IPR040191; UTP10.
DR PANTHER; PTHR13457; PTHR13457; 1.
DR Pfam; PF08146; BP28CT; 1.
DR Pfam; PF12397; U3snoRNP10; 1.
DR SMART; SM01036; BP28CT; 1.
DR SUPFAM; SSF48371; SSF48371; 2.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW rRNA processing.
FT CHAIN 1..2096
FT /note="HEAT repeat-containing protein 1 homolog"
FT /id="PRO_0000186204"
FT REPEAT 2058..2094
FT /note="HEAT"
FT CONFLICT 748
FT /note="Q -> P (in Ref. 3; AAT94407 and 4; AAL39945)"
FT /evidence="ECO:0000305"
FT CONFLICT 831
FT /note="E -> D (in Ref. 3; AAT94407 and 4; AAL39945)"
FT /evidence="ECO:0000305"
FT CONFLICT 902
FT /note="I -> T (in Ref. 3; AAT94407 and 4; AAL39945)"
FT /evidence="ECO:0000305"
FT CONFLICT 1019
FT /note="Q -> H (in Ref. 3; AAT94407)"
FT /evidence="ECO:0000305"
FT CONFLICT 1184
FT /note="V -> I (in Ref. 3; AAT94407 and 4; AAL39945)"
FT /evidence="ECO:0000305"
FT CONFLICT 1545
FT /note="I -> L (in Ref. 3; AAT94407 and 4; AAL39945)"
FT /evidence="ECO:0000305"
FT CONFLICT 1574
FT /note="S -> T (in Ref. 3; AAT94407 and 4; AAL39945)"
FT /evidence="ECO:0000305"
FT CONFLICT 1602
FT /note="E -> Q (in Ref. 3; AAT94407 and 4; AAL39945)"
FT /evidence="ECO:0000305"
FT CONFLICT 1626
FT /note="L -> F (in Ref. 3; AAT94407 and 4; AAL39945)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2096 AA; 237220 MW; 3E7B3C67CE6DF62C CRC64;
MSTALAQQLQ KLAAPQSSVT LADARSRASI LFDPKEAATK DRRSIYEIGL TGLQELTDFN
PAFKEFQLTL FDEATLTLER SVELPEINKM LDAAIAKFLR LLSPYLLLRP AHMAFEWLLR
RFQVHEYNRS EVMALILPYH ETMIFVQIVK TMRLRSSDGD WYWLRPLQRP GVPLAKTAII
NRAASNPAFL GFICQSTQKA VKELGPRAHQ LQAQINFYAT VVVGALQTAK PLQDWHITTI
LESLLRGLIS DNIDFMAAAY VIVAQLVSRT KLKSKVCNAL LERVANCPFE RLHSESLLLL
VCIYGKQQAA LPHFKPETIL NLVGKKWLIS TLSSLAKGNI AIQSICMPLM TGAVAAIRDD
DASSNSCKLF LDNLLSEVPM PKPTAQQLIN CFLDTYVETA IDAPEPMETN SNEDDDTIVI
DSDDEIETEK TTFQAWYSTY LEKLERRYPE AFDLSVKEAL RSKSSTSNRQ KALKLALGFR
LNTTDEKAKH AYEKLYHYSA DWRLSAVQKL LQNLNVTKKR ERSVKLLQEC LPDRINDDSG
AVVSTLLSLP TEELAEMLGP LPLAQTLCHL LYRAQSEKDE EWQPVVPLAV RHLTSALVSG
SYDTNLVLLA LMPLLFPGEA LAEHQHKALR ILLGSDFVSK VPFLAELKVS NKFSDFNVGE
HRQHFLDIIA SSNQELSSQE RALLQSVEDH GGELYIQKAS QLTHLLLLLT AYAKRELQPR
ESLHMLEKIG LYSRRLQFRV VNGSQNTQNC APLQLYVDFL LTLVKNTKWT ALASTPWNQM
TDELRLCLRL LEIICAQVFS EKADQPERQE WTRALQQSLQ LILPEAQDRL EVLSNFYVFE
RLPELWPRDS DYAVFRLQGF IILEAVLSNP KSQIDCGLVH VLRVANACGS PLQTLRVQAI
NILQLISNRK LVSHVEQLVR SLLQRKSELS MDHEQYALIL YTILEPEKAT AKERLVLSKL
KRSVLALASD PKQSPICTAS LLAALKHVND ENFLNELLPL GLDSLKTITA GEDNQNIKQL
PWPHSEIYKS VIERFEGRVA LNVLLRKDLA WKLFEDSFAQ YDTYVQLEQK LQPLPCVLLN
SLTPETFEQM HAKHKIALIK LIVESATNSD NDSIFLASHR LLKRCRLDCQ PLVPILLEMA
NTKVEKKQPV KRRSVQATQL DLTSPYWKQG MTLLELLEHK KQLVGAELLI PPLFELLQAC
LTMEEHSAAE YPKQLILSSL LHCCQTAQSA GVQLVKAMPE SSFRIELVVQ SLRNTRNPQT
QQHALLFLTH CAGMYPQQVL HKIVEIFTFV GSTVARHDDA FSLHIIHNVV ESIIPILLLN
TGHNELVIPV LKVFADICTD VPVHRRLPLY ATLFRVLEPK EHLWQFLCII FESQVLLEQV
PQKVSTDKSR LDFARELTLM FEDPTVAIQT CIRLLDYLAK LPATKSSLSG GSGSSVLSTE
QQLFDVRTRT FKQLRHYKYL IMDFLSGISS CNEWEKKMKR PDPNELLPYY QEFILKTLAY
VGVLNGALEA ASETPSLEKF WRVLANHAHD VLDNAIGLLA PQHFISVITE LLKHDHVYVR
IKVMDLLVTK LSPSSDYFQQ SNAEHFGVLF APLQEIINGI LEGSSNSAQQ AKLQQTALHA
LQLLALRHGR DYIEECRSLL ATLTKITKRR ANVPKAVVGN VVLTLVEICA SLKAHALAQL
PKFAPQLTEL LKEQVHQMAS LKQGPDYVCS TLVTALHKLF KALPLFLGPY LVDIIGGLAR
LSVQLENPQL LQDKRTQVLK QKLADVWSAV AQGVEVRILV PSCAKAFSSL LEQQAYDELG
HLMQQLLLQS VRHNSAAQLQ PVQDPLSELF LQALNFRLQV RGLGLQRQLV SDVEASITET
FVTWILKLSE TSFRPMYSRV HKWALESTSR ETRLTYFLLT NRIAEALKSL FVLFASDFVE
DSSRLLTEHN SIRPEFEVEE REDDVDLLMA ILNTLHHVFL YCSEDFINDH RFNVLMPPLV
NQLENDLVLG NESLQQVLSN CIAQFAVATN DVMWKQLNSQ VLLKTRTSNP EVRILAFNSC
VAIARKLGES YAALLPETVP FIAELLEDEH QRVEKNTRTG VQELETILGE SVQKYL
