ID   HEAT1_MACFA             Reviewed;         958 AA.
AC   Q9GM44;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 2.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=HEAT repeat-containing protein 1;
DE   AltName: Full=Protein BAP28;
DE   Flags: Fragment;
GN   Name=HEATR1; Synonyms=BAP28; ORFNames=QnpA-17571;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Parietal cortex;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K.,
RA   Suzuki Y., Sugano S., Hashimoto K.;
RT   "Isolation of full-length cDNA clones from macaque brain cDNA libraries.";
RL   Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Ribosome biogenesis factor. Involved in nucleolar processing
CC       of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA
CC       transcription by RNA polymerase I. {ECO:0000250|UniProtKB:Q9H583}.
CC   -!- SUBUNIT: May be a component of the proposed t-UTP subcomplex of the
CC       ribosomal small subunit (SSU) processome containing at least UTP4,
CC       WDR43, HEATR1, UTP15, WDR75. {ECO:0000250|UniProtKB:Q9H583}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9H583}.
CC   -!- SIMILARITY: Belongs to the HEATR1/UTP10 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB16728.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AB049842; BAB16728.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; Q9GM44; -.
DR   SMR; Q9GM44; -.
DR   STRING; 9541.XP_005539772.1; -.
DR   PRIDE; Q9GM44; -.
DR   eggNOG; KOG1837; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR012954; BP28_C_dom.
DR   InterPro; IPR040191; UTP10.
DR   PANTHER; PTHR13457; PTHR13457; 1.
DR   Pfam; PF08146; BP28CT; 1.
DR   SMART; SM01036; BP28CT; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Phosphoprotein; Reference proteome; Ribonucleoprotein;
KW   Ribosome biogenesis; rRNA processing; Transcription;
KW   Transcription regulation.
FT   CHAIN           <1..958
FT                   /note="HEAT repeat-containing protein 1"
FT                   /id="PRO_0000186202"
FT   REPEAT          920..956
FT                   /note="HEAT"
FT   MOD_RES         4
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H583"
FT   MOD_RES         305
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H583"
FT   NON_TER         1
SQ   SEQUENCE   958 AA;  108645 MW;  3DBD95C3623CFB31 CRC64;
     QKKSQDLESV QEVGGSYWQR VTLILELLQH KKKLKSPQIL VPTLFNLLSR CLEPLPQEQG
     NMEYTKQLIL SCLLNICQKL SPDGGKIPKD VLDEEKFNVE LIVQCVRLSE MAQTHHHALL
     LLGTVAGIFP DKVLHNIMSI FTFMGANVMR LDDTYSFQVI NKTVKMVIPA LIQSDSGDSI
     EVSRNVEEIV VKIISVFVDA LPHVPEHRRL PILVQLVDTL GAEKFLWVLL ILLFEQYVTK
     TVLAAAYGEK DAILEADTEF WFSVCCEFSV QHQIQSLMNI LQYLLKLPEE KEETISKAVS
     NKSESQEEML QIFNVETHTS KQLRHFKFLS VSFMSQLLSS NNFLKKVVES GGPEILKGLE
     ERLLETVLGY INAVAQSMER NADKLTVKFW RALLSKAYDL LDKVNALLPT ETFIPVIRGL
     VGNRLPSVRR KALDLLNNKL QQNISWKKTI VTRFLKLVPD LLAIVQRKKK EGEEEQAINR
     QTALYTLKLL CKNFGAENPD PFVPVLSTAV KLIAPERKEE KNVLGSALLC VAEVTSTLQA
     LAVPQLPSLM PSLLTTMKNT SELVSSEVYL LSALAALQKV VETLPHFISP YLEGILSQVI
     HLEKITSEVG SASSQANIRL TSLKKTLATT LAPRVLLPAI RKTYKQIEKN WKNHMGPFMS
     ILQEHIGVMK KEELTSHQSQ LTAFFLEALD FRAQHSENDL EEVGRTENCI IDCLVAMVVK
     LSEVTFRPLF FKLFDWAKTE DAPKDRLLTF YNLADCIAEK LKGLFTLFAG HLVKPFADTL
     NQVNISKTDE AFFDSENDPE KCCLLLQFIL NCLYKIFLFD TQHFISKERA EALMMPLVDQ
     LENRLGGEEK FQERVTKQLI PCIAQFSVAM ADDSLWKPLN YQILLKTRDA SPKVRFAALI
     TVLALAEKLK ENYIVLLPES IPFLAELMED ECEEVEHQCQ KTIQQLETVL GEPLRSYF