HEAT3_MOUSE
ID HEAT3_MOUSE Reviewed; 679 AA.
AC Q8BQM4; Q8C731;
DT 15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=HEAT repeat-containing protein 3;
GN Name=Heatr3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Corpus striatum, and Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15 AND SER-144, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Liver, Lung, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
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DR EMBL; AK047782; BAC33155.1; -; mRNA.
DR EMBL; AK052635; BAC35071.1; -; mRNA.
DR EMBL; BC065060; AAH65060.1; -; mRNA.
DR CCDS; CCDS22508.1; -.
DR RefSeq; NP_766345.3; NM_172757.3.
DR AlphaFoldDB; Q8BQM4; -.
DR SMR; Q8BQM4; -.
DR BioGRID; 231539; 2.
DR STRING; 10090.ENSMUSP00000034079; -.
DR iPTMnet; Q8BQM4; -.
DR PhosphoSitePlus; Q8BQM4; -.
DR EPD; Q8BQM4; -.
DR MaxQB; Q8BQM4; -.
DR PaxDb; Q8BQM4; -.
DR PeptideAtlas; Q8BQM4; -.
DR PRIDE; Q8BQM4; -.
DR ProteomicsDB; 269553; -.
DR Antibodypedia; 49437; 63 antibodies from 12 providers.
DR DNASU; 234549; -.
DR Ensembl; ENSMUST00000034079; ENSMUSP00000034079; ENSMUSG00000031657.
DR GeneID; 234549; -.
DR KEGG; mmu:234549; -.
DR UCSC; uc009mrc.1; mouse.
DR CTD; 55027; -.
DR MGI; MGI:2444491; Heatr3.
DR VEuPathDB; HostDB:ENSMUSG00000031657; -.
DR eggNOG; ENOG502QWR9; Eukaryota.
DR GeneTree; ENSGT00390000012529; -.
DR HOGENOM; CLU_028600_0_0_1; -.
DR InParanoid; Q8BQM4; -.
DR OMA; YRKFGLE; -.
DR OrthoDB; 475746at2759; -.
DR PhylomeDB; Q8BQM4; -.
DR TreeFam; TF324159; -.
DR BioGRID-ORCS; 234549; 23 hits in 74 CRISPR screens.
DR ChiTaRS; Heatr3; mouse.
DR PRO; PR:Q8BQM4; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8BQM4; protein.
DR Bgee; ENSMUSG00000031657; Expressed in ectoplacental cone and 217 other tissues.
DR ExpressionAtlas; Q8BQM4; baseline and differential.
DR Genevisible; Q8BQM4; MM.
DR GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..679
FT /note="HEAT repeat-containing protein 3"
FT /id="PRO_0000050822"
FT REPEAT 38..69
FT /note="HEAT 1"
FT REPEAT 74..110
FT /note="HEAT 2"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 15
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 144
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 339
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q7Z4Q2"
FT CONFLICT 282
FT /note="V -> A (in Ref. 1; BAC35071)"
FT /evidence="ECO:0000305"
FT CONFLICT 467
FT /note="M -> I (in Ref. 1; BAC35071)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 679 AA; 74305 MW; EC4C3A5665DD241E CRC64;
MGKSRTKRFK RPQFSPIESC QAEAAAASNG TGDEEDDGPA AELLEKLQHP SAEVRECACA
GLARLVQQRP ALPDLARRDA VRRLGPLLLD SSLAVRETAA GALRNLSACG GFDVCDDMVA
KDIMTPLVAL LRECLSGLDS NEMSPQEKAD KRNPVESIAN EAVNVLWNVC ECSGRAVSIF
NKEGCLEIVL QYLRRFPTSI DLAVSVAYCL QTVTEDNPEL LKSFDGTALR VLESALLCPV
ASMEYILLKT LVAGTIWNLK DIIPSKSQAE IINAILGALS EVLGMNTGNM VIQMKEAETQ
RLKTAAESED ILANANGDDL VEDDEMEEIP HKRKLRRKTF ISDLLPPTDK ELREAMALLT
AQQTALEVIV NMCCSEDPSD DEWEELSSSD ESEAFMENSF SECSGHLMSP LCLSHEIHSA
LTNCLIPEKV FEKTSSPNSV AVDICSKNPT WKPLIRKMNT IQCRALMCLQ SLVSLLDIDH
LGGAPALQTL AQHLSQILFS QPDFAKHDDF LEAISSALRA LLQTMASKNI PQCMTPEQLM
TLCREGIHSS SIGVRVNVVS ILGITGSVLA KDDGTLDTLK TIGCFLLEVA TKDPSLVVTG
EALDALFDVF ADGEAAEKAS VQIKLLAALK EFQPVFKMKI RKEGRGKYSP DQLCVLDNVK
MNLRRFIAYQ ETVEKRLTS
