ID   HEAT6_DANRE             Reviewed;        1201 AA.
AC   A9JRI0;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=HEAT repeat-containing protein 6;
GN   Name=heatr6; ORFNames=zgc:172359;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; BC155667; AAI55668.1; -; mRNA.
DR   RefSeq; NP_001107785.1; NM_001114313.1.
DR   AlphaFoldDB; A9JRI0; -.
DR   STRING; 7955.ENSDARP00000097730; -.
DR   PaxDb; A9JRI0; -.
DR   PeptideAtlas; A9JRI0; -.
DR   GeneID; 567838; -.
DR   KEGG; dre:567838; -.
DR   CTD; 63897; -.
DR   ZFIN; ZDB-GENE-080204-118; heatr6.
DR   eggNOG; KOG4535; Eukaryota.
DR   InParanoid; A9JRI0; -.
DR   OrthoDB; 106835at2759; -.
DR   PhylomeDB; A9JRI0; -.
DR   PRO; PR:A9JRI0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   Gene3D; 1.25.10.10; -; 3.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR025283; DUF4042.
DR   Pfam; PF13251; DUF4042; 1.
DR   SUPFAM; SSF48371; SSF48371; 2.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat.
FT   CHAIN           1..1201
FT                   /note="HEAT repeat-containing protein 6"
FT                   /id="PRO_0000337177"
FT   REPEAT          182..221
FT                   /note="HEAT 1"
FT   REPEAT          460..498
FT                   /note="HEAT 2"
FT   REPEAT          523..560
FT                   /note="HEAT 3"
FT   REPEAT          566..603
FT                   /note="HEAT 4"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          321..390
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          618..653
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        374..390
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        618..633
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1201 AA;  130503 MW;  E157CDBCB8461119 CRC64;
     MAGKVTFLGS NSSFSPDGKT QGFKSASADT SRFVSLSKPQ HELDGSAQAQ ISRCFNKLRS
     LSPSDSASLK TELNLLFDEL ISENYSSSNH DNIPPEVVCE ILVQASRLVP LSQEHLIIKL
     CQMIHQLLNQ LQIIVDEHTL DVLVSYCSRA LRTCSSWTHS EVLLALSSLV YGNGSKCQRY
     LPDLLGPSGV LVKYGDPKQP DIELRRSAVH CIANLCLSVP SQPYLEEPYK SVCYGILLRT
     LQSTKPPDVD DIVFCTLLQS ALKGMQYFLN GGKWKAVPNQ DLGALLAVLK RFMFYGLPGI
     SVEMPQVLYP APLPQYETIP AVKPEPAQDT PAQKKTAASQ QKKRKSRGKG KKGAGEGKQD
     GEADDVSAAG GGDQSGWSHG SQSSMLTSPS VATPQLYPSW KKCSSDSEFS DPEGGMQSKL
     RLYQARVRQS SLQCFLAVVK CVEKRILYGY WSSFVPDAPG IGGPPPLTLL TIALKDPLPK
     VRAGSLQVLS ALLEGSRQFL STAEDTGAPR QAFTPFSATL AASIRELHRG LLLALIAESS
     CQTLTQVLKC LAHLVSNVPY NRLRPGLLSP LWKQIRPYVR HRDVNVRVSS LTLFGALVST
     QAPLPEVQLL LQQPGSASSL GSGISTPQES PLSWRQPARR DEEASSPAAA EGPEGPCWLL
     QLCVSLVTQP REEPYSDSDA GGSNGAPLEP SPVRLEALQV LAHLVKGYFS LAQASLLELG
     QLSARCLTEQ DPSVQLHGAK LLEELGTGII QQYRADANTP QSAKRVPVNQ VVQFWSEVLG
     GPLISALQNE HHPTLQTSAC DTLSSILPQA FSQLPDKTQV LCITILLGLT YSENSLVKAA
     AVRALGVYIL FPCLREDVMF VADTANAILT ALDDRSPNVR AKAAWSLGNL TDTLIVNMQS
     VGLEFQEDFS DMLLLNMLRS ATKASADKDR VKSNAVRALG NLLHFLQPGH LGKPVFEQPL
     LEAMRALIDT VRGDATMKVR WNACYALGNA FRNQHLPLGS AVWSTEAFSA LSCVVTSCKN
     FKVRIKSAAA LSVPATRECY GDSQQFSEVW RSLAQALEHS EETEDFLEYR YCASLRSQLC
     RALLHLLSLC QPDDLPALGS SVSGQSRPAL QALLISHLRD EGLVPSAGAD GEEALDHSTP
     EDGWTLLTDT LTRLKGLLGE PVMDSNEDLE SVLSFLQDVV RNFEEMKEAE SKESSLVLGK
     S